Protein
MIA_04715_1
Length
1,146 amino acids
Browser: contig06:800688-804175+
Protein function
| EGGNOG: | 0PGVC | MSH3 | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate-binding and substrate-specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity) |
|---|---|---|---|
| SGD closest match: | S000000688 | MSH3 | DNA mismatch repair protein MSH3 |
| CGD closest match: | CAL0000179035 | MSH3 | DNA mismatch repair protein MSH3 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_05164_1 | 43.394% | 1090 | 0.0 | MCA_05164_1 |
| A0A0J9X3S9_GEOCN | 41.691% | 1041 | 0.0 | Similar to Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends OS=Geotrichum candidum GN=BN980_GECA02s01858g PE=3 SV=1 |
| UniRef50_A0A0J9X3S9 | 41.691% | 1041 | 0.0 | Similar to Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3S9_GEOCN |
| A0A1E3PGX6_9ASCO | 42.390% | 887 | 0.0 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52294 PE=3 SV=1 |
| A0A167EK33_9ASCO | 42.729% | 894 | 0.0 | Mismatch repair protein MSH3 OS=Sugiyamaella lignohabitans GN=MSH3 PE=3 SV=1 |
| A0A060TCH1_BLAAD | 38.534% | 955 | 0.0 | ARAD1D39248p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39248g PE=3 SV=1 |
| A0A1E4THF9_9ASCO | 38.041% | 878 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31913 PE=3 SV=1 |
| MSH3_YARLI | 34.029% | 911 | 6.95e-155 | DNA mismatch repair protein MSH3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MSH3 PE=3 SV=1 |
| MSH3_CANAL | 34.058% | 966 | 3.76e-143 | DNA mismatch repair protein MSH3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MSH3 PE=3 SV=1 |
| MSH3_YEAST | 33.333% | 933 | 6.69e-140 | DNA mismatch repair protein MSH3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH3 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.6710
Protein family membership
- DNA mismatch repair protein MutS/MSH (IPR017261)
Domains and repeats
-
Domain
-
Domain
1
200
400
600
800
1000
1146
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MIA_04715_1 MASSPYFSNGARPKKPVKKKKTAQQTLVSAFFSKKKEPSTTSSEAPPKTPPVSSPKKSPEPPTLEPPLNGSKRPLEESNE ADTSKKPRPDPCNSDESSPQDTVQNKPHPPKQLSKPSRKTLEQISSQRQQKFAYKTPGSTPANPHQDNDQEDSEKQIAFK KARHELFYAKLHKPGAIEVIKRKGPVDTTQKENDPPEEADPDENLDLESNYKDSLSKFANKSSAKKPAAKKKLTPMNQQY VDLKRQHQDIILFIEIGYKYYLFGEDAQIASKELRIFFKAGKLTLDENDPQDAKYPTYAYTTILSTTLEKHIKRLVDKGY KVGIVKQAETAAQKAYGKNKSAPFERKLTQVYTKSTMVDFFDMSKPTAPAEDGKTGYLMAITEAPASSESQSDKQHIGIV AVQALTGEIIYDDFIDSSVMHSELETRLLHLQPSEVLVVGQVNKTTKKLLKQLAVSKSLNFEPRIETVKRLDINSSDDYI NCFYNKKAADCRDDKVGDLLGQKLDFVDTLPDLVRICLAALMSYLKDFGLDVVFDLTNNFSPFNTKTHMHLNGNTITSLE LFQNQTNYKVQGSLFNLIDYTRTPFGKRQLRQWIAKPLIDRKMIENRIQAVNELKTQRSAGVGIIVSTLNSLCDLERCLI SIYYKRVSPKNLYHFLNNLRRVSEVFKTNPDSFNLESEYLKNIFTTLPLAHDIVTEFLAEIDVNNATKDQKTEFFIETDS TYEEVSEKRVELIMLKERINKYLENEKKRLKIKSLKYIAVAGTPYYLNVSRSEASKVPDTWQKYSQTSAAGRYRSLELNE MVQEFNFLNDTIKMLSEALFDQFLDRINIYYATFRNIIHAIADLDCYISLLSIATLPHFVCPKFVDYACCNIVQGRHPMV EYAGLDNDKYTYVANDTKMTYDHDRAVIITGPNMGGKSSYVRQVALICIMAQIGCHVPADSATLGIVDAVYTRMGAYDNM QAGESTFQVELKECSDILSSATNRSLVLLDEIGRGTGTMDGVAIAHAVLEYFINTVKCLTLFVTHYPSLAELEERYAAVS NYHMGFLEEPNADIPGESKIIFLYTLVRGVAHNSYGLNVARLAEIPESIIASAKKMADHLKEQVVTRQDLCLSTDMARLI SKCNDVQPEKFSEDDWKAVYRLFSNV
GO term prediction
Biological Process
GO:0006298 mismatch repair
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
Cellular Component
None predicted.