Protein
MCA_05164_1
Length
1,122 amino acids
Gene name: MSH3
Description: DNA mismatch repair protein MSH3
Browser: contigD:505213-508582-
RNA-seq: read pairs 384, FPKM 4.2, percentile rank 16.2% (100% = highest expression)
Protein function
| Annotation: | MSH3 | DNA mismatch repair protein MSH3 | |
|---|---|---|---|
| KEGG: | K08736 | MSH3 | DNA mismatch repair protein MSH3 |
| EGGNOG: | 0PGVC | MSH3 | Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with msh-2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. Msh-3 provides substrate-binding and substrate-specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity) |
| SGD closest match: | S000000688 | MSH3 | DNA mismatch repair protein MSH3 |
| CGD closest match: | CAL0000179035 | MSH3 | DNA mismatch repair protein MSH3 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04715_1 | 42.09% | 1138 | 0.0 | MIA_04715_1 |
| A0A1E3PGX6_9ASCO | 40.39% | 921 | 0.0 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52294 PE=3 SV=1 |
| UniRef50_A0A1E3PGX6 | 40.39% | 921 | 0.0 | Uncharacterized protein n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PGX6_9ASCO |
| A0A0J9X3S9_GEOCN | 38.33% | 1020 | 0.0 | Similar to Saccharomyces cerevisiae YCR092C MSH3 Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends OS=Geotrichum candidum GN=BN980_GECA02s01858g PE=3 SV=1 |
| A0A167EK33_9ASCO | 40.24% | 932 | 0.0 | Mismatch repair protein MSH3 OS=Sugiyamaella lignohabitans GN=MSH3 PE=3 SV=1 |
| A0A060TCH1_BLAAD | 38.79% | 972 | 0.0 | ARAD1D39248p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D39248g PE=3 SV=1 |
| A0A1E4THF9_9ASCO | 33.11% | 909 | 3e-162 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31913 PE=3 SV=1 |
| MSH3_YARLI | 33.48% | 929 | 3e-144 | DNA mismatch repair protein MSH3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=MSH3 PE=3 SV=1 |
| MSH3_CANAL | 32.43% | 962 | 4e-136 | DNA mismatch repair protein MSH3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MSH3 PE=3 SV=1 |
| MSH3_YEAST | 32.38% | 945 | 8e-135 | DNA mismatch repair protein MSH3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH3 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.6573
Protein family membership
- DNA mismatch repair protein MutS/MSH (IPR017261)
Domains and repeats
-
Domain
-
Domain
1
200
400
600
800
1000
1122
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_05164_1 MSSSSSRRKPESSNKKFSKSSQHLFSKYFFSQKKDSEINEEQKKQISEVPVNSVGKRPLEETEIGKSNKKIKTLQNAAYP KEKLKLPSLKQVEDVTKKRRLAFSFNPSSIKISDKPSSVIPSERHEDFVKKLEKVEKSKALQEKENSVEDDYSDGTNDVN VKKGTKKLTPMNQQYVDLKKQHPDVLLLIEMGYKYQMFGSDAQTVSKELHTFIKPGKLTIDPNDPNDAKYDTYAYTTFLS TALDKNVSKLVKLGYKVGIVEQMETSALKAQGSNKSAPFQRKLTRLYTKGTYIYNQTMESFQGKGLNSNRETVYSDGYLI AICENKTFTDQFHIGFLAIQLSTGEVIIDQFQDTVMHTELETRLLHLSPLEILLVGKVNSNITKLIDQLTNSNTLNLEPR IAKVDQVDESDVSMDLHNFYKNLLSEPSNEEFQKKTYQYLDYVDQLPNLVKICLVAVINYLKEFELETVFKHNQTFIPFS SKSHMNLNGNTIVSLELFQNLFDHTSHGSLFSILDFTRTPFGQRLLKKWITKPLVDKNLIEERISVTQELAHNFTESMSF LLNSMSKLPDLEKGLASIYYKRIKPRQLYYFLSNIKGICNIINNAPAETFQFTTKPLKNIVDCIKMAFDPCNKYLDELNT DQVSEFDSDITCVFKNQLEKYDEISDFMIRITLTQEDIENLCFTTKSEHGFKTLSYVTINKSPYYFNVSTSETGKVPTDW IKYSQTKTYGRYRSPDLEKKIRDLLFLQDSLKECCQKAYKSFLQEISDNHFETFKQTIQSLATLDCFLSLTAVSAQSGYV KPQFVDAPCIKFEQGRHPVVERFKNSGGDTEKCENNDNNTNGAFRYVPNDTKMETDDNRVVILTGPNMGGKSSYARQVGL ICIMAQIGSFVPCKSACLGIIDGIYTRMGAQDNFMRGESTFQVELKECRDILVSATDRSLVILDEIGRGTGTMDGVSIAY AVLKSMIEDVKSFTLFITHYQNLTKVAAESTNNSLGKKMICNYHMGFKEHDLMEDNDTDKSNMGFQKTRIEFLYTLEPGI AHRSYGLYVAQLANLSPEIIQRAYEISKHLETVINKRKLDKWTKIMCQFLLDYEKSNEKEKKEEFSIMEKNQLKYLFNSL EN
GO term prediction
Biological Process
GO:0006298 mismatch repair
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
Cellular Component
None predicted.