Protein
MIA_04690_1
Length
705 amino acids
Browser: contig06:733362-735778+
Protein function
| EGGNOG: | 0PHHT | PAN3 | Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab1. Deadenylation of the 3'-tail to a length that is too short to bind pab1 induces mRNA decay. May also be involved in post- transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting pan2 to mRNA via its interaction with pab1 (By similarity) |
|---|---|---|---|
| SGD closest match: | S000001508 | PAN3 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 |
| CGD closest match: | CAL0000174293 | PAN3 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_01331_1 | 63.441% | 651 | 0.0 | MCA_01331_1 |
| A0A0J9XHI5_GEOCN | 50.827% | 665 | 0.0 | Similar to Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex (Partial) (Fragment) OS=Geotrichum candidum GN=BN980_GECA16s02474g PE=3 SV=1 |
| UniRef50_A0A0J9XHI5 | 50.827% | 665 | 0.0 | Similar to Saccharomyces cerevisiae YKL025C PAN3 Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex (Partial) (Fragment) n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XHI5_GEOCN |
| A0A060T864_BLAAD | 46.273% | 644 | 0.0 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Blastobotrys adeninivorans GN=PAN3 PE=3 SV=1 |
| A0A167EFD2_9ASCO | 52.268% | 463 | 1.28e-163 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Sugiyamaella lignohabitans GN=PAN3 PE=3 SV=1 |
| A0A1E3PQS4_9ASCO | 37.861% | 692 | 2.67e-136 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=PAN3 PE=3 SV=1 |
| PAN3_YARLI | 39.261% | 568 | 1.88e-113 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=PAN3 PE=3 SV=1 |
| PAN3_CANAL | 32.249% | 707 | 3.33e-85 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PAN3 PE=3 SV=2 |
| A0A1E4TD57_9ASCO | 38.031% | 447 | 8.46e-81 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_27837 PE=4 SV=1 |
| PAN3_YEAST | 29.913% | 692 | 7.27e-73 | PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PAN3 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1082
Protein family membership
Domains and repeats
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Domain
1
100
200
300
400
500
600
705
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
cd00180 (PKc)
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mobidb-lite (disord...)
Residue annotation
-
active site cd00180
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ATP binding site c...
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polypeptide substr...
Protein sequence
>MIA_04690_1 MPNTLKGDSHSSAPAKVFSHPSASTTPCRNILIHGYCKYADKGCVFNHDASLTLVQQPQPPSPLGISSTFKKKLNADPPS FTPSYTNLSNFQTGSSSTLASNGSHSAPLPQSNTATGKAKISPKVASISPFIPKNFQSNGQIQNQTSSSNPVGSYSPDIF RPGQSTPFKSASLSPGINLSAQLSQTSLDDYAQNSYDMNSSLEYNNMPHYHQDMYYQSHTSYPLQYHLYAPNIWRDRHLL PHQRVPENFFIQNDLRENLQRKNEAALQTLPASTLPEYVHVYHSLVPLDTTLEKSTRVFGYPSWIYKACSNEDGKLYALR RIEGFRLTNEKAMAAVPQWHKLVNAGVVRIKEAFTTRAFGDNSVVFVYDYYAMSRTLMSVHFGPESYQQMNRIVIAEKLV WSYATQLLSALRTIHGAKLAARIIEPSRILLTDSNRIRLNCCGIFDVIHYDHLQPLETSQHEDLLNFGKLLLSLCNSSLG SSQYLETSLANVEKTYSGDLYELLRYTFDTDSVSAAEKLEHLITLSASHAYDTLNDTLEYNSFLLGELSTELENGRLVRL LCKLGAVNERPEHAHDAAWSETGPRYPLKLFRDYVFHQTDEVGVPVVDLAHMLRELNKLDAGIDEPVMLTSRDEQTYMLV TYKELKECMGSAFRELKSDGGAAAAAAAAAAAVAASAGNAPVMNSGGGDSSLVFIPAAAAARRPM
GO term prediction
Biological Process
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
Molecular Function
GO:0003723 RNA binding
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0046872 metal ion binding
Cellular Component
GO:0031251 PAN complex