Protein

MIA_04686_1

Length
466 amino acids

Browser: contig06:727575-729204-

Protein function

EGGNOG:0PM14PGUG_00052Mitochondrial pyruvate dehydrogenase kinase
SGD closest match:S000001304PKP1[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MCA_01327_167.910%4025.61e-179MCA_01327_1
A0A0J9XBU8_GEOCN57.218%3818.31e-142Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity OS=Geotrichum candidum GN=BN980_GECA08s04168g PE=4 SV=1
A0A060T741_BLAAD57.031%3841.06e-133ARAD1D00440p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00440g PE=4 SV=1
UniRef50_A0A060T74157.031%3842.61e-130ARAD1D00440p n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T741_BLAAD
A0A1E3PNF5_9ASCO56.216%3703.72e-130Alpha-ketoacid dehydrogenase kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45211 PE=4 SV=1
Q6C5A5_YARLI50.746%3353.26e-104YALI0E19679p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E19679g PE=4 SV=1
A0A1E4TLM8_9ASCO47.765%3589.45e-105Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56259 PE=4 SV=1
PDK1_YEAST29.973%3771.38e-42[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1
A0A167F269_9ASCO28.302%4246.44e-34Protein kinase PKP2 OS=Sugiyamaella lignohabitans GN=PKP2 PE=4 SV=1
A0A1D8PTU9_CANAL30.844%3083.99e-27Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9637
Predicted cleavage: 45

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 466

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  3. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
  4. Domain IPR004358
    Signal transduction histidine kinase-related protein, C-terminal
    1. PR00344 (BCTRLSENSOR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. cd00075 (HATPase_c)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MIA_04686_1
MKRLARSRLHFFPGSVLPKTSRRRLGSLAFASCNPASNCPTHRISSPHYCDCHHDVSSFRLRPSTGDFARSFSSSSAIMQ
DFHHLTKKNTEELDHLERTALERLIYEYASYELDPIHLDDLLALGKPPISEKVLLENAAYVLRQTTARLAHRLQALRNLP
YLIVLNPSISQIYSIYFNSFRVVSQIEPPKTLEENDYIVEILEQLVAAHTDTIPILSRGFWEARQYISAEEVTSVLDNHL
RARIGTRMLAENHIALTRPIDPAHFIGAVEVDCNPATILQSTATFVGDICDLKYGLVPHIEFDNQKGQAVTIPYVPVHLE
YIFTELLKNAFRATVEFTHKQFQEGSLSSVLDSDQDLASQLPPVMVTIVKTSTGVIIRIRDRGGGIPPAIEKNIWDYSFS
TFDDGEGDGFATLNAAPGNSIAGLGYGLPLSRAYAEFFGGKLQIQSYFGWGTDVYLTLNTPKYTKV

GO term prediction

Biological Process

GO:0016310 phosphorylation

Molecular Function

GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

None predicted.