Protein

MCA_01327_1

Length
435 amino acids

Gene name: PKP1B

Description: [Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial

Browser: contigA:4161296-4162776-

RNA-seq: read pairs 1329, FPKM 37.7, percentile rank 59.0% (100% = highest expression)

Protein function

Annotation:PKP1B[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
EGGNOG:0PM14PGUG_00052Mitochondrial pyruvate dehydrogenase kinase
SGD closest match:S000001304PKP1[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial
CGD closest match:CAL0000180154PDK2Protein kinase

Protein alignments

%idAln lengthE-value
MIA_04686_168.08%4014e-180MIA_04686_1
A0A0J9XBU8_GEOCN61.79%3901e-157Similar to Saccharomyces cerevisiae YIL042C PKP1 Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity OS=Geotrichum candidum GN=BN980_GECA08s04168g PE=4 SV=1
A0A060T741_BLAAD55.53%3985e-140ARAD1D00440p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D00440g PE=4 SV=1
UniRef50_A0A060T74155.53%3981e-136ARAD1D00440p n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T741_BLAAD
A0A1E3PNF5_9ASCO52.74%3831e-130Alpha-ketoacid dehydrogenase kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45211 PE=4 SV=1
Q6C5A5_YARLI47.69%3902e-111YALI0E19679p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E19679g PE=4 SV=1
A0A1E4TLM8_9ASCO46.79%3745e-106Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_56259 PE=4 SV=1
PDK1_YEAST28.64%3983e-42[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PKP1 PE=1 SV=1
A0A167F269_9ASCO28.19%4087e-34Protein kinase PKP2 OS=Sugiyamaella lignohabitans GN=PKP2 PE=4 SV=1
A0A1D8PTU9_CANAL28.08%3176e-21Protein kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PDK2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.6613
Predicted cleavage: 14

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 435

Detailed signature matches

  1. Domain IPR018955
    Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase, N-terminal
    1. SSF69012 (alpha-ket...)
    2. G3DSA:1.20.14...
    3. PF10436 (BCDHK_Adom3)
  2. Domain IPR003594
    Histidine kinase-like ATPase, C-terminal domain
    1. G3DSA:3.30.56...
    2. PF02518 (HATPase_c)
    3. SSF55874 (ATPase do...)
    4. SM00387 (HKATPase_4)
  3. Domain IPR005467
    Histidine kinase domain
    1. PS50109 (HIS_KIN)
  4. Domain IPR004358
    Signal transduction histidine kinase-related protein, C-terminal
    1. PR00344 (BCTRLSENSOR)
Unintegrated signatures no IPR
Unintegrated signatures
  1. cd00075 (HATPase_c)

Residue annotation

  1. ATP binding site c...
  2. Mg2+ binding site ...
  3. G-X-G motif cd00075

Protein sequence

>MCA_01327_1
MRIRYITHAARLRPVLSYKQHHLNHLLFQSYNRGLHHLTKVAAQELDHYAKVELEKSISKYASYEQAQINLEDLLALGKS
PVPEDVLLKNAEHVLHQTTIRLAHRLNALRQLPYLIVLNPSISQIYSIYFNSFRVVSQTKAPKTIEENAEFVEILDQLVQ
AHSDTIPILSRGFHEARQYISMEESSKILDTHLRARIGTRLIAEHHIALTNPIDPDEYIGAVEIACKPSRILKHTAAFVG
DICDLKYGVVPQIKFDNPQGIDATIPYIPVHLEYMFTELLKNAFRASIEFAQKQPKKHKNNGEMIQEEEEDNYIFSTSLN
EPLAPVLITIVKTSTGLIIRIRDRGGGIPPALENKVFDYSFTTFDDSQGEGDGVGSSGFSTLNAVPGGNSIAGLGYGLPL
SRAYAEFFGGKLQIQTYYGWGTDVYITLKAPNYPK

GO term prediction

Biological Process

GO:0016310 phosphorylation

Molecular Function

GO:0016772 transferase activity, transferring phosphorus-containing groups

Cellular Component

None predicted.