Protein
MIA_04630_1
Length
996 amino acids
Browser: contig06:567876-570867+
Protein function
| EGGNOG: | 0PJ7K | FG09725.1 | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity) |
|---|---|---|---|
| SGD closest match: | S000000118 | PIM1 | Lon protease homolog, mitochondrial |
| CGD closest match: | CAL0000175783 | CAALFM_C305360CA | Lon protease homolog 2, peroxisomal |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_05584_1 | 65.700% | 1035 | 0.0 | MCA_05584_1 |
| A0A0J9XHM4_GEOCN | 55.600% | 1009 | 0.0 | Lon protease homolog 2, peroxisomal OS=Geotrichum candidum GN=BN980_GECA18s02012g PE=3 SV=1 |
| UniRef50_A0A0J9XHM4 | 55.600% | 1009 | 0.0 | Lon protease homolog 2, peroxisomal n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XHM4_GEOCN |
| LONP2_YARLI | 46.686% | 1026 | 0.0 | Lon protease homolog 2, peroxisomal OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F23595g PE=3 SV=1 |
| A0A167CHR3_9ASCO | 57.161% | 768 | 0.0 | Lon protease homolog OS=Sugiyamaella lignohabitans GN=PIM1 PE=3 SV=1 |
| A0A1E4TKS7_9ASCO | 54.470% | 727 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22778 PE=3 SV=1 |
| A0A060T5V1_BLAAD | 55.245% | 715 | 0.0 | Lon protease homolog OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15312g PE=3 SV=1 |
| A0A1E3PLN4_9ASCO | 45.161% | 930 | 0.0 | Lon protease homolog OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82105 PE=3 SV=1 |
| LONP2_CANAL | 42.115% | 539 | 8.71e-121 | Lon protease homolog 2, peroxisomal OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C305360CA PE=3 SV=1 |
| LONM_YEAST | 38.004% | 471 | 2.87e-92 | Lon protease homolog, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PIM1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0567
Protein family membership
- Lon protease homologue 2, peroxisomal (IPR027501)
Domains and repeats
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Domain
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Domain
1
100
200
300
400
500
600
700
800
900
996
Detailed signature matches
no IPR
Unintegrated signatures
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-
-
-
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PR00830 (ENDOLAPTASE)
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cd00009 (AAA)
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mobidb-lite (disord...)
Residue annotation
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Walker A motif cd0...
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ATP binding site c...
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Walker B motif cd0...
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arginine finger cd...
Protein sequence
>MIA_04630_1 MTDNVIATATLPIFALPSGTVIFPGITVRVPLDTSEANTIVSRLNKFARFVSEHTPKIKGSESLLDSDASQDPNSPTPEQ LAVETKTLHSVLGLKDTLTEGTRSPLITIGVLPRVDPSLPVDSKSSNAAYLTSNLTKTLSPSFPASQESLKSIVHPFGIV ARVARIERSLNGRVHALLEGFNRIRVDQFTQVGTETEARVSVYSEDGASVDKKLSIWPREELEKLEALKKVALSLIELMS TKSGTYSANNNLAIRPELLKKIIPLIKQSRTRRAAGILTDILAFIIPIEYEDKIKLLGAVSLNERIDMVTTLIEQYIESE KISEKIDKSVEDSISKQQREFILRQKLNAIKEELGEKGSGSASSGKGGFGNRAASPNANDEEEEEDIADLKKKLDTLRLP EDGQKIVTRELKRLKRMHPTQAEYQVCRTYLETIAELPWSTATSDRLDENPVARAKKILDDDHYGLNKVKKRLLEYLAVL HLKQEQKLRKSGKPQQTSTALVPYKKDDQQKYDSDDLAVHEIKSNDEVLSLDKSPILLLVGPPGVGKTSLAKSVAHALGR KFHRISLGGVRDEAEIRGHRRTYVGAMPGVLVQSLRKVGVINPVILLDEIDKVSKSNFHGDPSAALLEVLDPEQNHTFTD HYINFPVDLSKTLFIATANSLDDIPAPLLDRMETINIEGYTYMDKQKIAKEYLIPKQIGNNGLVPGQLEITDEAILKIAT HYTREAGVRNLEREVGTLCRGKAVEYAKTEETHGEYISKVDVGDLIKYLGVESFEDDMVYDEVDVYIDAKTGERKRRHAY GVVNGLAYMGSGNGGLLMFEATAIPGGNGNLKTTGQLGSVIAESAELSLSWVRANAYRLGLTSSPEEDVVKDINIHLHAP AGAIPKDGPSAGVAMTLTLISLLAKRPVPRDLALTGEMTLRGKILAVGGIREKLLGAHITGVRRVLLPYHTRKVVEEEYT FVKDTKLEITYVKYIWDVLALVWPEEQFPTVIDSHL
GO term prediction
Biological Process
GO:0006508 proteolysis
GO:0006515 misfolded or incompletely synthesized protein catabolic process
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
None predicted.