Protein
MCA_05584_1
Length
1,020 amino acids
Description: Lon protease homolog 2, peroxisomal
Browser: contigD:1721191-1724254+
RNA-seq: read pairs 929, FPKM 11.2, percentile rank 27.9% (100% = highest expression)
Protein function
| Annotation: | Lon protease homolog 2, peroxisomal | ||
|---|---|---|---|
| KEGG: | K01338 | lon | ATP-dependent Lon protease [EC:3.4.21.53] |
| EGGNOG: | 0PJ7K | FG09725.1 | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import (By similarity) |
| SGD closest match: | S000000118 | PIM1 | Lon protease homolog, mitochondrial |
| CGD closest match: | CAL0000175783 | CAALFM_C305360CA | Lon protease homolog 2, peroxisomal |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04630_1 | 65.70% | 1035 | 0.0 | MIA_04630_1 |
| A0A0J9XHM4_GEOCN | 56.02% | 1021 | 0.0 | Lon protease homolog 2, peroxisomal OS=Geotrichum candidum GN=BN980_GECA18s02012g PE=3 SV=1 |
| UniRef50_A0A0J9XHM4 | 56.02% | 1021 | 0.0 | Lon protease homolog 2, peroxisomal n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A0J9XHM4_GEOCN |
| LONP2_YARLI | 47.17% | 1024 | 0.0 | Lon protease homolog 2, peroxisomal OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0F23595g PE=3 SV=1 |
| A0A167CHR3_9ASCO | 56.29% | 787 | 0.0 | Lon protease homolog OS=Sugiyamaella lignohabitans GN=PIM1 PE=3 SV=1 |
| A0A1E4TKS7_9ASCO | 54.19% | 740 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22778 PE=3 SV=1 |
| A0A060T5V1_BLAAD | 54.16% | 733 | 0.0 | Lon protease homolog OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C15312g PE=3 SV=1 |
| A0A1E3PLN4_9ASCO | 47.21% | 877 | 0.0 | Lon protease homolog OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82105 PE=3 SV=1 |
| LONP2_CANAL | 37.50% | 752 | 3e-141 | Lon protease homolog 2, peroxisomal OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_C305360CA PE=3 SV=1 |
| LONM_YEAST | 34.26% | 721 | 6e-117 | Lon protease homolog, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PIM1 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0508
Protein family membership
- Lon protease homologue 2, peroxisomal (IPR027501)
Domains and repeats
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Domain
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Domain
1
100
200
300
400
500
600
700
800
900
1020
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
-
-
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PR00830 (ENDOLAPTASE)
-
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cd00009 (AAA)
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mobidb-lite (disord...)
Residue annotation
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Walker A motif cd0...
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ATP binding site c...
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Walker B motif cd0...
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arginine finger cd...
Protein sequence
>MCA_05584_1 MPSNQQDSVIATAVLPIFALPFNTVLFPGITVRVNLAPSEAATIITRLNDFAKRIQDPPTLLSTSNHDTNKAIEDAKQYE EVRSLHNILDLKESAANSNSPLITVGVVPRIMNEINSKENNNSNLLLADNIENGSFLTSDLTKSFSSQSAPIKSETLSNV IYPFGIVARVLRVERSFNGKFQAVIEGFNRLHIDEFTKVGDFTEARVSVFAEDSSSSDVKVSIWSREDLEKLESLKLAAI RLISHLSTNMPTANNKSGSQVGNNRFLVKPELLRKILPMVKQTKSRRAAGILTDILAFIIPIEYHDKVKLLEVTSLNQRI DLVTKLMNEYIEAAKITEKIDKSVEDSISKQQREFILRQKLNAIKEELGEKNGGAFKGGMSKGANADNDEDEEISELKKK LDDADIPEEGRKIVNREFKRLKRMHPTQAEYQVCRTYLETIAEVPWSTATFDNLDNDPVARARKILDDDHYGLEKVKKRL LEYLAVLNLKQKHQMKSKAITLKEDSVDPIEDGKKTNASSPTSTALVPYQGDKKSSEPAVHKITSDTKILSLDKSPILLL VGPPGVGKTSLAKSVAHALGRKFHRISLGGVRDEAEIRGHRRTYVGAMPGLLVQALRKVGVVNPVILLDEIDKVSQSNFH GDPSAALLEVLDPEQNHTFTDHYINFPVDLSKTLFIATANYLEDIPGPLLDRMEMISLEGYTYMEKEKIAQNYLIPKQME INGLEKEQLEITDEAILKIATNYTREAGVRNLERQIGSICRGKAVEYAESIADKNKPYNKVVGVDDLHKYLGVGHYEDDM VNDEVDEYYDKETGEKHRRHTYGVVNGLAYMGSGNGGLLMFEASLMSGHGNLKTTGQLGSVIAESADIALSWVRSNAFRL GLTASPEEDLMKDVDIHLHAPAGAIPKDGPSAGVAMTVTFISLFAKKPVPRNLAMTGEMTLRGKILPVGGIREKLLGAHL AGIQKVLLPYHTKKLVEQEDFFKTFLKNIDLEIVYVKYIWDVLAEIWPEENFPVLLDSHI
GO term prediction
Biological Process
GO:0006508 proteolysis
GO:0006515 misfolded or incompletely synthesized protein catabolic process
Molecular Function
GO:0004176 ATP-dependent peptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005524 ATP binding
Cellular Component
None predicted.