MIA_04613_1

Protein

Length

1,715 amino acids

Protein function

EGGNOG:	0QEED	STH1	K11786 ATP-dependent helicase STH1 SNF2 EC 3.6.4
SGD closest match:	S000001388	STH1	Nuclear protein STH1/NPS1
CGD closest match:	CAL0000193582	orf19.239	RSC chromatin remodeling complex ATPase subunit

Protein alignments

	%id	Aln length
MCA_04569_1	70.320%	1095	MCA_04569_1
A0A0J9XDF0_GEOCN	67.563%	1079	Similar to Saccharomyces cerevisiae YIL126W STH1 ATPase component of the RSC chromatin remodeling complex OS=Geotrichum candidum GN=BN980_GECA11s02914g PE=4 SV=1
A0A167DSF8_9ASCO	65.753%	1095	RSC chromatin remodeling complex ATPase subunit STH1 OS=Sugiyamaella lignohabitans GN=STH1 PE=4 SV=1
A0A060SXN1_BLAAD	65.374%	1109	ARAD1A10626p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A10626g PE=4 SV=1
A0A1E3PSV0_9ASCO	65.226%	1064	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81447 PE=4 SV=1
Q6CDE1_YARLI	62.581%	1077	YALI0C01243p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C01243g PE=4 SV=2
A0A1E4TJU7_9ASCO	58.240%	1159	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22566 PE=4 SV=1
UniRef50_W6MWU6	57.709%	1135	Uncharacterized protein n=4 Tax=Saccharomycetales TaxID=4892 RepID=W6MWU6_9ASCO
A0A1D8PJG4_CANAL	58.465%	1016	RSC chromatin remodeling complex ATPase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.239 PE=4 SV=1
STH1_YEAST	57.821%	1074	Nuclear protein STH1/NPS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STH1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0006
Predicted cleavage: 106

Protein family membership

None predicted.

Domains and repeats

Domain
634 - 710
Helicase/SANT-associated domain (IPR014012)
770 - 1,026
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,028 - 1,320
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
1,516 - 1,675
Bromodomain (IPR001487)
Domain
795 - 987
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
1,318 - 1,396
Snf2, ATP coupling domain (IPR029295)
Domain
811 - 1,097
SNF2-related, N-terminal domain (IPR000330)
1,121 - 1,285
Helicase, C-terminal (IPR001650)

1 200 400 600 800 1000 1200 1400 1600 1715

Detailed signature matches

IPR014012

Helicase/SANT-associated domain
1. PS51204 (HSA)
  
  634 - 710
  
  PROSITE profiles
  PS51204 (HSA)
2. PF07529 (HSA)
  
  639 - 709
  
  Pfam
  PF07529 (HSA)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  1,028 - 1,320
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  770 - 1,026
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  811 - 976
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  795 - 987
  
  SMART
  SM00487 (ultradead3)
IPR000330

SNF2-related, N-terminal domain
1. PF00176 (SNF2_N)
  
  811 - 1,097
  
  Pfam
  PF00176 (SNF2_N)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  1,124 - 1,285
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,150 - 1,234
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,121 - 1,234
  
  Pfam
  PF00271 (Helicase_C)
IPR029295

Snf2, ATP coupling domain
1. PF14619 (SnAC)
  
  1,318 - 1,396
  
  Pfam
  PF14619 (SnAC)
2. SM01314 (SnAC_2)
  
  1,331 - 1,396
  
  SMART
  SM01314 (SnAC_2)
IPR001487

Bromodomain
1. PR00503 (BROMODOMAIN)
  
  1,592 - 1,611
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,558 - 1,574
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,574 - 1,592
  
  PRINTS
  PR00503 (BROMODOMAIN)
2. SM00297 (bromo_6)
  
  1,516 - 1,630
  
  SMART
  SM00297 (bromo_6)
3. SSF47370 (Bromodomain)
  
  1,533 - 1,628
  
  SUPERFAMILY
  SSF47370 (Bromodomain)
4. PS50014 (BROMODOMAIN_2)
  
  1,541 - 1,611
  
  PROSITE profiles
  PS50014 (BROMODOMAIN_2)
5. G3DSA:1.20.92...
  
  1,518 - 1,675
  
  GENE3D
  G3DSA:1.20.920.10 (G3DSA:1.20.920.10)
6. PF00439 (Bromodomain)
  
  1,545 - 1,615
  
  Pfam
  PF00439 (Bromodomain)
IPR018359

Bromodomain, conserved site
1. PS00633 (BROMODOMAIN_1)
  
  1,546 - 1,603
  
  PROSITE patterns
  PS00633 (BROMODOMAIN_1)

no IPR

Unintegrated signatures

Coil

1,714 - 1,715

COILS
Coil (Coil)

691 - 711

COILS
Coil (Coil)
G3DSA:3.40.50...

763 - 1,025

GENE3D
G3DSA:3.40.50.10810 (G3DSA:3.40.50.10810)
G3DSA:3.40.50...

1,106 - 1,272

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00046 (DEXDc)

819 - 958

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,120 - 1,242

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

1,631 - 1,715

MobiDB Lite
mobidb-lite (disorder_prediction)

1,434 - 1,508

MobiDB Lite
mobidb-lite (disorder_prediction)

122 - 271

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 68

MobiDB Lite
mobidb-lite (disorder_prediction)

303 - 367

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

827G

ATP binding site
827G, 828L, 829G, 830K, 831T
CDD
cd00046 (DEXDc)

828L

ATP binding site
827G, 828L, 829G, 830K, 831T
CDD
cd00046 (DEXDc)

829G

ATP binding site
827G, 828L, 829G, 830K, 831T
CDD
cd00046 (DEXDc)

830K

ATP binding site
827G, 828L, 829G, 830K, 831T
CDD
cd00046 (DEXDc)

831T

ATP binding site
827G, 828L, 829G, 830K, 831T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

926D

putative Mg++ binding site
926D, 927E, 928G, 929H
CDD
cd00046 (DEXDc)

927E

putative Mg++ binding site
926D, 927E, 928G, 929H
CDD
cd00046 (DEXDc)

928G

putative Mg++ binding site
926D, 927E, 928G, 929H
CDD
cd00046 (DEXDc)

929H

putative Mg++ binding site
926D, 927E, 928G, 929H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,144Q

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,145M

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,146T

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,147Q

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,167D

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,168G

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,196T

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,197R

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)

1,198A

nucleotide binding region
1,144Q, 1,145M, 1,146T, 1,147Q, 1,167D, 1,168G, 1,196T, 1,197R, 1,198A
CDD
cd00079 (HELICc)
ATP-binding site c...

1,204N

ATP-binding site
1,204N, 1,225Q, 1,229R, 1,232R
CDD
cd00079 (HELICc)

1,225Q

ATP-binding site
1,204N, 1,225Q, 1,229R, 1,232R
CDD
cd00079 (HELICc)

1,229R

ATP-binding site
1,204N, 1,225Q, 1,229R, 1,232R
CDD
cd00079 (HELICc)

1,232R

ATP-binding site
1,204N, 1,225Q, 1,229R, 1,232R
CDD
cd00079 (HELICc)

Protein sequence

>MIA_04613_1
MNNSNIPYNPTGGQDQHQQAYPHHPQHLPLQQHPAHLQYQQQQQFAGHQFQPQQQQSQPQQQPQQQQQPILNGYASHIPL
QIPPQQQQQQQQLAPRALSVQQQQQIQQPIAQQIQDPNSIKSVMAHHQQQQQQQQQMMIPPPTQPHQQVINNIPTQTPSS
VPLQLPSQSPTPIPIQHPRPQQVSQQIPQQVPQQVPQQVSQQVSQQAPQQVPQQASQGVPSMMPIPPGPQPPLNNQGPHM
QQISIQQNQGPHIPQGQSTPQTHPVQHVQTVQNQQPIPQAPLSQQVPSSQSPSVSLASTPIQAHINPGTQPAVNPSPIST
NSASPSVPAASVPPPPMQQLPSQAVPTNSFNGQNPATASAESTPVPSEFVIPKPETREQYQLLLLRWNALNSVGADQKSH
SAHPEYAAICKIIKQAGREQKLYQLRFDEIKKAKSKSLTKSKSSDEVKIKLISNQIKAFQLLSHNLDIPPQFQEALLEPF
TSDDKEPSPIFSSSVISGGKYRSRSERINVSLVGDASSTDKKSIDTREQIISNKITQRIVELERLPGNLGTLDVKNADLE
PSHNIPNNDDELKIKALIELKSLRLLTKQKSLRQGIVFSLANSTDPISESMTLRYNNRRQKIHSAQDLRITEQLETQQRL
ERERKERVRHINSIKGICLQAKQVLNDRHNKHQKHISMGRAIGQAHTTIEKEEQKRAERTAKQRLQALKANDEEAYIKLL
DQTKDTRITHILGQTNSFLDSLAQRVKVQQQEVDSIKPKTQSISGEDDDEKERVDYYEVAHRIKEEVTKQPSILVGGTLK
EYQLKGLQWMVSLYNNNLNGILADEMGLGKTIQSVSLITYLIETKKNPGPYLVIVPLSTLTNWTLEFEKWAPSVKTIVYK
GPPPARRVHQAAIRNGDFQVLLTTYEYIIKDRPILSKIKWAHMIIDEGHRMKNTNSKLSYTLTQYYTSSHRLILTGTPLQ
NNLPELWALLNFVLPKIFNSVKTFDEWFNTPFANTGGQDKMELNEEETLLIIRRLHKVLRPFLLRRLKKDVEKDLPDKVE
KVVKCKMSALQSKLYQHMLKHNVIFVGQEGVGGNKSGIKGLNNRIMQLRKICNHPFVFEETENLVNPTHTNNEMLWRVAG
KFELLDRILPKFKATGHRVLMFFQMTQVMDIMEDYLRYRNMKYLRLDGATKADERSGMLKLFNAPNSEYFAFLLSTRAGG
LGLNLQTADTVIIYDTDWNPHQDLQAQDRAHRIGQTKEVRILRLITEDSVEESILSRAHAKLEIDGKVIQAGKFDQKSTA
EEQEAFLRSLLEAEEAKRNQNDDDEDIDDDELNEILARNDEEAVIFKKIDEERNATSPYGRDKPHDRLFGEDELPEELKR
DIVEHIDNEPQEVLGRGARERKKVYYDDVLTEDQWLEAIDNEDDVEEAIKRERLHQEQLRKNREAKKLRKVTISDDEEED
VKVAEEIEEKREDTPELETKKRKRGPGRRKSTPKVIDDEEPKADEEEDEEIVANGNAEESDEEELRKTNDRLSNNINVSL
DMVTEMGQAILTEIEDSTDEDGRTRVDLFLELPDRKMYRDYYKVIRRPIALDKIRKKLETGKYLSIDDMANDLFLMSANA
MKYNQVDSHVYLDAQAIKKMVEEWAERSKKTISEVDNASNGSASPGQDGKDAEAPPLKKLRVSSDNDDNVNGDLANGDGT
PNGNEGGEEVPRPPSRGKGRPKGSRNGTKRGNRRK

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042393 histone binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MIA_04613_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component