MCA_04569_1

Protein

Length

1,599 amino acids

Gene name: STH1

Description: Nuclear protein STH1/NPS1

Browser: contigC:3405069-3410001-

RNA-seq: read pairs 6141, FPKM 47.4, percentile rank 64.3% (100% = highest expression)

Protein function

Annotation:		STH1	Nuclear protein STH1/NPS1
KEGG:	K11786	STH1_SNF2	ATP-dependent helicase STH1/SNF2 [EC:3.6.4.-]
EGGNOG:	0QEED	STH1	K11786 ATP-dependent helicase STH1 SNF2 EC 3.6.4
SGD closest match:	S000001388	STH1	Nuclear protein STH1/NPS1
CGD closest match:	CAL0000193582	orf19.239	RSC chromatin remodeling complex ATPase subunit

Protein alignments

	%id	Aln length
MIA_04613_1	69.71%	1096	MIA_04613_1
A0A0J9XDF0_GEOCN	66.06%	1046	Similar to Saccharomyces cerevisiae YIL126W STH1 ATPase component of the RSC chromatin remodeling complex OS=Geotrichum candidum GN=BN980_GECA11s02914g PE=4 SV=1
A0A060SXN1_BLAAD	64.84%	1061	ARAD1A10626p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A10626g PE=4 SV=1
A0A1E3PSV0_9ASCO	63.87%	1060	Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81447 PE=4 SV=1
A0A167DSF8_9ASCO	63.80%	1069	RSC chromatin remodeling complex ATPase subunit STH1 OS=Sugiyamaella lignohabitans GN=STH1 PE=4 SV=1
Q6CDE1_YARLI	63.11%	1041	YALI0C01243p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C01243g PE=4 SV=2
A0A1E4TJU7_9ASCO	62.50%	936	Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22566 PE=4 SV=1
UniRef50_W6MWU6	55.36%	1120	Uncharacterized protein n=4 Tax=Saccharomycetales TaxID=4892 RepID=W6MWU6_9ASCO
STH1_YEAST	57.77%	1068	Nuclear protein STH1/NPS1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=STH1 PE=1 SV=1
A0A1D8PJG4_CANAL	58.05%	1013	RSC chromatin remodeling complex ATPase subunit OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.239 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5727
Predicted cleavage: 299

Protein family membership

None predicted.

Domains and repeats

Domain
576 - 649
Helicase/SANT-associated domain (IPR014012)
734 - 926
Helicase superfamily 1/2, ATP-binding domain (IPR014001)
1,062 - 1,226
Helicase, C-terminal (IPR001650)
1,259 - 1,338
Snf2, ATP coupling domain (IPR029295)
1,420 - 1,544
Bromodomain (IPR001487)
Domain
708 - 965
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
967 - 1,272
P-loop containing nucleoside triphosphate hydrolase (IPR027417)
Domain
749 - 1,038
SNF2-related, N-terminal domain (IPR000330)

1 200 400 600 800 1000 1200 1400 1599

Detailed signature matches

IPR014012

Helicase/SANT-associated domain
1. SM00573 (bromneu2)
  
  577 - 649
  
  SMART
  SM00573 (bromneu2)
2. PS51204 (HSA)
  
  576 - 649
  
  PROSITE profiles
  PS51204 (HSA)
3. PF07529 (HSA)
  
  578 - 648
  
  Pfam
  PF07529 (HSA)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  967 - 1,272
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
  
  708 - 965
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)
IPR014001

Helicase superfamily 1/2, ATP-binding domain
1. PS51192 (HELICASE_A...)
  
  750 - 915
  
  PROSITE profiles
  PS51192 (HELICASE_ATP_BIND_1)
2. SM00487 (ultradead3)
  
  734 - 926
  
  SMART
  SM00487 (ultradead3)
IPR000330

SNF2-related, N-terminal domain
1. PF00176 (SNF2_N)
  
  749 - 1,038
  
  Pfam
  PF00176 (SNF2_N)
IPR001650

Helicase, C-terminal
1. PS51194 (HELICASE_CTER)
  
  1,065 - 1,226
  
  PROSITE profiles
  PS51194 (HELICASE_CTER)
2. SM00490 (helicmild6)
  
  1,091 - 1,175
  
  SMART
  SM00490 (helicmild6)
3. PF00271 (Helicase_C)
  
  1,062 - 1,175
  
  Pfam
  PF00271 (Helicase_C)
IPR029295

Snf2, ATP coupling domain
1. PF14619 (SnAC)
  
  1,259 - 1,338
  
  Pfam
  PF14619 (SnAC)
2. SM01314 (SnAC_2)
  
  1,272 - 1,338
  
  SMART
  SM01314 (SnAC_2)
IPR001487

Bromodomain
1. PR00503 (BROMODOMAIN)
  
  1,483 - 1,501
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,501 - 1,520
  
  PRINTS
  PR00503 (BROMODOMAIN)
  
  1,467 - 1,483
  
  PRINTS
  PR00503 (BROMODOMAIN)
2. SSF47370 (Bromodomain)
  
  1,430 - 1,539
  
  SUPERFAMILY
  SSF47370 (Bromodomain)
3. SM00297 (bromo_6)
  
  1,432 - 1,539
  
  SMART
  SM00297 (bromo_6)
4. PS50014 (BROMODOMAIN_2)
  
  1,450 - 1,520
  
  PROSITE profiles
  PS50014 (BROMODOMAIN_2)
5. G3DSA:1.20.92...
  
  1,420 - 1,544
  
  GENE3D
  G3DSA:1.20.920.10 (G3DSA:1.20.920.10)
6. PF00439 (Bromodomain)
  
  1,451 - 1,524
  
  Pfam
  PF00439 (Bromodomain)
IPR018359

Bromodomain, conserved site
1. PS00633 (BROMODOMAIN_1)
  
  1,455 - 1,512
  
  PROSITE patterns
  PS00633 (BROMODOMAIN_1)

no IPR

Unintegrated signatures

Coil

1,338 - 1,358

COILS
Coil (Coil)

630 - 650

COILS
Coil (Coil)

127 - 212

COILS
Coil (Coil)

1,231 - 1,254

COILS
Coil (Coil)
G3DSA:1.20.10...

307 - 664

GENE3D
G3DSA:1.20.1000.10 (G3DSA:1.20.1000.10)
G3DSA:3.40.50...

702 - 964

GENE3D
G3DSA:3.40.50.10810 (G3DSA:3.40.50.10810)
G3DSA:3.40.50...

1,048 - 1,213

GENE3D
G3DSA:3.40.50.300 (G3DSA:3.40.50.300)
cd00046 (DEXDc)

758 - 897

CDD
cd00046 (DEXDc)
cd00079 (HELICc)

1,061 - 1,183

CDD
cd00079 (HELICc)
mobidb-lite (disord...)

688 - 713

MobiDB Lite
mobidb-lite (disorder_prediction)

221 - 279

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 106

MobiDB Lite
mobidb-lite (disorder_prediction)

1,557 - 1,599

MobiDB Lite
mobidb-lite (disorder_prediction)

1,274 - 1,433

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

766G

ATP binding site
766G, 767L, 768G, 769K, 770T
CDD
cd00046 (DEXDc)

767L

ATP binding site
766G, 767L, 768G, 769K, 770T
CDD
cd00046 (DEXDc)

768G

ATP binding site
766G, 767L, 768G, 769K, 770T
CDD
cd00046 (DEXDc)

769K

ATP binding site
766G, 767L, 768G, 769K, 770T
CDD
cd00046 (DEXDc)

770T

ATP binding site
766G, 767L, 768G, 769K, 770T
CDD
cd00046 (DEXDc)
putative Mg++ bind...

865D

putative Mg++ binding site
865D, 866E, 867G, 868H
CDD
cd00046 (DEXDc)

866E

putative Mg++ binding site
865D, 866E, 867G, 868H
CDD
cd00046 (DEXDc)

867G

putative Mg++ binding site
865D, 866E, 867G, 868H
CDD
cd00046 (DEXDc)

868H

putative Mg++ binding site
865D, 866E, 867G, 868H
CDD
cd00046 (DEXDc)
nucleotide binding...

1,085Q

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,086M

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,087T

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,088Q

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,108D

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,109G

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,137T

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,138R

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)

1,139A

nucleotide binding region
1,085Q, 1,086M, 1,087T, 1,088Q, 1,108D, 1,109G, 1,137T, 1,138R, 1,139A
CDD
cd00079 (HELICc)
ATP-binding site c...

1,145N

ATP-binding site
1,145N, 1,166Q, 1,170R, 1,173R
CDD
cd00079 (HELICc)

1,166Q

ATP-binding site
1,145N, 1,166Q, 1,170R, 1,173R
CDD
cd00079 (HELICc)

1,170R

ATP-binding site
1,145N, 1,166Q, 1,170R, 1,173R
CDD
cd00079 (HELICc)

1,173R

ATP-binding site
1,145N, 1,166Q, 1,170R, 1,173R
CDD
cd00079 (HELICc)

Protein sequence

>MCA_04569_1
MIGGYAMGQQQQPQQPQQQQSAPQYQYSQQFAHQPQIQAQYPVQQPVGMVPQFQQPQQLQMHQVQQQPSQPQQPQQQIQH
MQQHMGHQISQRMPPSPQQQQNPQINPQTNQIQLQMSQAQAQQQFHLAQARAQAQQQQAQQQAQQAQQQAQQQAQQQAQQ
QAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQQAQQAQARVNHQVVVQSRAQTMSRPGPPIAQPQPHI
PQSTQNMAPHSQPPAQYPLGQIPSNPTTPVPFSQSGQQLPVSQPVNNIPVSSPQVARASASASPTPAAALKKITVAKPET
CEQYHLMLLRWNTLKNEGADETSNPEFAAISDIIRKSAKQQTQYESRLAQLKKIKAAKKTEKSPEHTRLLECQIKAFQLL
SHNLDLTEEIQDLLLESKLPAKKFEPSFSTTSVDHKDFSSRAKHAHIPPSGGYQVIFSKENNPEKQEKIISNKISQRITQ
LERLPANLGTLDSKDISLKSSENIPDNNDYLKIRALIELKALRLLTKQKSLRQHLVFSLATLSDPISDSINIRCNHRRVK
VPTSQDLRITEKLETQQRLERERKERLRQSSVINGIKNHAHQINAEKHSRTAKALALGQSILQAHNYIEKEEQRRAERTA
KQRLQALKANDEEAYIKLLDQTKDTRITHLLKQTNSFLDSLTQRVKAQQQEGTSRRVRRNSSGEESDEESDRADYYEVAH
RIKEEIKVQPSILVGGKLKDYQIKGLQWMVSLYNNNINGILADEMGLGKTIQSISLITYLIEMKHKPGPFLVIVPLSTLP
NWVLEFEKWAPSVKKVVYKGTPNERRIHQSTIRSGDFQVLLTTYEYIIKDRPLLSKIKWIHMIIDEGHRMKNKNSKLSVT
LTEYYTTSHRLILTGTPLQNSLPELWALLNFVLPKIFNSVKTFDEWFNTPFANTGSQEKLELNEEETLLIIRRLHKVLRP
FLLRRLKKDVEKDLPDKVERVIKCKMSALQYKLYQHMLKYKAIFVGGDEGKPGKTKNGVKGLNNRIMQLRKICNHPFVFE
ETENLINPTHTNNDNLWRVAGKFELLDRILPKFKATGHRVLIFFQMTQIMDIMEDYLRYRGLMYLRLDGGTKADERSSML
KLFNAPDSPYFAFLLSTRAGGLGLNLQTADTVIIYDTDWNPHQDLQAQDRAHRIGQTKEVRILRLITEDSVEESILSRAH
AKLEIDGKVIQAGKFDQKSTAEEQEAFLRSLLEAEEAKRNQSQEEEEIDDDELNEILARDENEAKVFKKIDDERNRTSGY
GPLAGKPRLFSEEELPEEFKKEDLIEDLDSQEPENLGRGARERKRVYYDDGLTEEQWLEAMDDDNDTVEDAIERKRLRRE
RRRERMESKANTDDEEEKPEPPVEEPEATTGKRKRGRRKSKKIVEDDEDEEEGPPTKKRETEDVSSSGQDIESHGMKIIN
QLLNDVDSDDDHNRSDLFMELPDKDMYDDYYSVIKSPISISIIESKIKSHKYKNLEGLKKDLILMVENAMEYNEADSIVY
NDALHFKGLVEKWYNDVINSNGESVAVAEGNGKVENEGSTLVVDEPVSQPVTPSGRGRGRGRRGGPGRGKKKFRGKSVI

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0005515 protein binding
GO:0005524 ATP binding
GO:0042393 histone binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

MCA_04569_1

Protein function

Protein alignments

Mitochondrial localization by mitoprotII

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

Protein sequence

GO term prediction

Biological Process

Molecular Function

Cellular Component