Protein

MIA_04591_1

Length
603 amino acids

Browser: contig06:442169-444050+

Protein function

EGGNOG:0PHG6PGUG_03398Pseudouridine synthase
SGD closest match:S000005427RIB2Bifunctional protein RIB2
CGD closest match:CAL0000193029orf19.3177Bifunctional DRAP deaminase/tRNA pseudouridine synthase

Protein alignments

%idAln lengthE-value
MCA_04400_174.872%5850.0MCA_04400_1
A0A0J9XAC0_GEOCN73.227%5640.0Similar to Saccharomyces cerevisiae YOL066C RIB2 Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity OS=Geotrichum candidum GN=BN980_GECA05s06852g PE=4 SV=1
A0A1E3PEH3_9ASCO63.889%5760.0Pseudouridine synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_53422 PE=4 SV=1
A0A060SZ03_BLAAD63.204%5680.0ARAD1A15862p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A15862g PE=4 SV=1
A0A1D8PND6_CANAL59.605%5570.0Bifunctional DRAP deaminase/tRNA pseudouridine synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.3177 PE=4 SV=1
Q6C1Z1_YARLI57.530%5910.0YALI0F12199p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F12199g PE=4 SV=1
UniRef50_A0A1X7RB6657.343%5720.0Similar to Saccharomyces cerevisiae YDL036C PUS9 Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs n=1 Tax=Kazachstania saulgeensis TaxID=1789683 RepID=A0A1X7RB66_9SACH
RIB2_YEAST56.437%5670.0Bifunctional protein RIB2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIB2 PE=1 SV=1
A0A167D3Y9_9ASCO65.600%3751.61e-165Bifunctional DRAP deaminase/tRNA pseudouridine synthase RIB2 OS=Sugiyamaella lignohabitans GN=RIB2 PE=4 SV=1
A0A1E4TM99_9ASCO54.964%4132.09e-156Pseudouridine synthase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_22508 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0024
Predicted cleavage: 19

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 603

Detailed signature matches

  1. Family IPR006225
    Pseudouridine synthase, RluC/RluD
    1. TIGR00005
  2. Domain IPR002942
    RNA-binding S4 domain
    1. G3DSA:3.10.29...
    2. PS50889 (S4)
  3. Domain IPR020103
    Pseudouridine synthase, catalytic domain
    1. SSF55120 (Pseudouri...)
  4. Domain IPR006145
    Pseudouridine synthase, RsuA/RluB/C/D/E/F
    1. PF00849 (PseudoU_sy...)
  5. Domain IPR016193
    Cytidine deaminase-like
    1. SSF53927 (Cytidine ...)
  6. Domain IPR002125
    Cytidine and deoxycytidylate deaminase domain
    1. PF00383 (dCMP_cyt_d...)
    2. PS51747 (CYT_DCMP_D...)
  7. SITE IPR006224
    Pseudouridine synthase, RluC/RluD, conserved site
    1. PS01129 (PSI_RLU)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.30.23...
  2. G3DSA:3.40.14...
  3. cd02557 (PseudoU_sy...)
  4. mobidb-lite (disord...)

Residue annotation

  1. probable active si...

Protein sequence

>MIA_04591_1
MDPNNPTLYSSVKGGQRDEGGFRVKRQTIQSQNTIDGAEISETIKEDSAQGARYVIDGNLRRVPPYYFTYLTFCKMRWRD
RNLLEVFTTEFRDKDRDYYHEAIETGQVMLNGKVADLDTIVRNGDQISHRTHKHEPPVTSRPIKIVYEDDELVVIDKPSG
IPVHPTGRYRFNTVVMVLKHEQGKYVHPCNRLDRLTSGLMFLAKSGKAADKMGAQLRDREVKKEYVARVKGEFPLGTIVV
EEPIATVAPKVALNRVKPDGKPAKTEFHRISYDGETSIVRCRPFTGRTHQIRVHLQYLGHPIANDPIYSNVWVWGEELGK
DGAGDDTELEARLSEIGRSRPASTWISPVDYTPFEEHAGDSSGTQIPKGMGEALAHEKCLDCKTDLYTDPGPNDLDLWLH
ALTYSSLDQSWSYATAYPEWALEPNRKFMEMAMDEARKCEGTTAAFSVGAVLVNNGKVLSTGYSRELPGNTHAEQCALEK
YFKQTGVQGTVPPGTVIYTTMEPCSERLSGNLPCVDRILAAANIKTVFVGVVEPDTFVANNTGRSKLTTAGIEYVHIPGY
EEECLAIATKKPGEEESKKELNGESKDEPKEEPKEEPKEEPKN

GO term prediction

Biological Process

GO:0001522 pseudouridine synthesis
GO:0009451 RNA modification

Molecular Function

GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0009982 pseudouridine synthase activity

Cellular Component

None predicted.