Protein

MIA_04587_1

Length
445 amino acids

Browser: contig06:434342-435680-

Protein function

EGGNOG:0PFQMDBP8ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity)
SGD closest match:S000001212DBP8ATP-dependent RNA helicase DBP8
CGD closest match:CAL0000181153DBP8ATP-dependent RNA helicase DBP8

Protein alignments

%idAln lengthE-value
MCA_01763_175.669%4110.0MCA_01763_1
A0A0J9XDI4_GEOCN70.388%4120.0Similar to Saccharomyces cerevisiae YHR169W DBP8 ATPase OS=Geotrichum candidum GN=BN980_GECA10s03409g PE=3 SV=1
A0A167D409_9ASCO68.932%4120.0ATP-dependent RNA helicase DBP8 OS=Sugiyamaella lignohabitans GN=DBP8 PE=3 SV=1
A0A1E3PMK0_9ASCO67.561%4100.0ATP-dependent RNA helicase DBP8 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_50464 PE=3 SV=1
A0A060T3I4_BLAAD66.828%4130.0ARAD1A15796p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1A15796g PE=3 SV=1
DBP8_YARLI65.937%4110.0ATP-dependent RNA helicase DBP8 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=DBP8 PE=3 SV=1
DBP8_CANAL60.922%4120.0ATP-dependent RNA helicase DBP8 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=DBP8 PE=3 SV=1
UniRef50_Q59PR360.922%4125.70e-179ATP-dependent RNA helicase DBP8 n=47 Tax=Eukaryota TaxID=2759 RepID=DBP8_CANAL
DBP8_YEAST58.537%4106.56e-178ATP-dependent RNA helicase DBP8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DBP8 PE=1 SV=1
A0A1E4TMH7_9ASCO57.590%4152.12e-161Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_21508 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1029

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 350 400 445

Detailed signature matches

  1. Domain IPR014014
    RNA helicase, DEAD-box type, Q motif
    1. PS51195 (Q_MOTIF)
  2. Domain IPR014001
    Helicase superfamily 1/2, ATP-binding domain
    1. PS51192 (HELICASE_A...)
    2. SM00487 (ultradead3)
  3. Domain IPR011545
    DEAD/DEAH box helicase domain
    1. PF00270 (DEAD)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR001650
    Helicase, C-terminal
    1. PS51194 (HELICASE_CTER)
    2. SM00490 (helicmild6)
    3. PF00271 (Helicase_C)
  6. SITE IPR000629
    ATP-dependent RNA helicase DEAD-box, conserved site
    1. PS00039 (DEAD_ATP_H...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. cd00079 (HELICc)
  4. cd00268 (DEADc)
  5. mobidb-lite (disord...)

Residue annotation

  1. ATP binding site c...
  2. Mg++ binding site ...
  3. motif III cd00268
  4. nucleotide binding...
  5. ATP-binding site c...

Protein sequence

>MIA_04587_1
MSFTSLGLPPWMAECLKNIAITKPSAIQEACIPPILDGRDCIGGAKTGSGKTIAFAAPMIAKWAEDPFGICGVVLTPTRE
LAIQIADQFAALGSGVGIKTCVVIGGVEMTKQSRDLKEKPHFVIATPGRLADEIRSNGEEILPGLRRVKFLVLDEADRLL
SSSMADDLATCIGALSPPEKRQTLLFTATVTDSVRALKDQPTKAGKKPVFVHEVASNEVAIPATLTQSYLFIPSYVRDAY
LYSILTHEDNASKSAIVFVNRTSTAEQVRRTLEKMEIKAVSLHSEMPQRDRINALAKFRAEVARVLVATDVASRGLDIPV
VEMVINFEIPADPDDYVHRVGRTARAGRRGESISLVSEQDVTLIQGIEERVGQKMEQYGKIDDDDVVNNALRPVSMAKRE
AIMDMDRDGFGELRKTREKKRRLKEAASAVIKNEKKKHRKKKGSS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0005524 ATP binding

Cellular Component

None predicted.