Protein

MIA_04568_1

Length
626 amino acids


Browser: contig06:381783-383748-

Protein function

EGGNOG:0PHQGFG00460.1SIR2 family histone deacetylase
SGD closest match:S000002599HST4NAD-dependent histone deacetylase HST4
CGD closest match:CAL0000186930HST3NAD-dependent histone deacetylase HST3

Protein alignments

%idAln lengthE-value
MCA_03974_163.846%3904.25e-169MCA_03974_1
A0A0J9XBY8_GEOCN63.333%3003.33e-145Similar to Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylase OS=Geotrichum candidum GN=BN980_GECA08s03321g PE=4 SV=1
UniRef50_A0A0J9XBY863.333%3006.82e-142Similar to Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XBY8_GEOCN
A0A167CEB9_9ASCO53.804%3681.21e-126Hst4p OS=Sugiyamaella lignohabitans GN=HST4 PE=4 SV=1
A0A060T5F6_BLAAD54.217%3325.99e-123ARAD1B10868p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B10868g PE=4 SV=1
Q6CB00_YARLI47.912%4073.20e-115YALI0C23034p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C23034g PE=4 SV=1
A0A1E4TKK8_9ASCO48.344%3021.22e-92Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16213 PE=4 SV=1
HST4_YEAST45.695%3021.02e-88NAD-dependent histone deacetylase HST4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST4 PE=1 SV=1
A0A1E3PPR1_9ASCO35.000%2806.26e-51NAD-dependent deacetylase HST3 (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_7079 PE=4 SV=1
HST3_CANAL33.007%3065.07e-48NAD-dependent histone deacetylase HST3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST3 PE=3 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0293

Protein family membership

Domains and repeats

1 100 200 300 400 500 626

Detailed signature matches

    1. PF02146 (SIR2)
    1. SSF52467 (DHS-like ...)
    1. PS50305 (SIRTUIN)
Unintegrated signatures no IPR
Unintegrated signatures
  1. mobidb-lite (disord...)

Protein sequence

>MIA_04568_1
MSSLPDTTPTETGATPLTSGLSTPLASVAAPTTSISRKPALPKRTLDAPDVFDMFDALHDETSHQYDRNKLRNIIHFRKP
KKRPEQVSEEYDSDEEIPEEVLMASYKQDIALLHHTLRHARRIVVISGAGISVAAGIPDFRSTTGLFRLLRNEFRLKGGV
SSGQQMFDASHVFSNQQALDNFHTTVCDLHSLCQKCQPTPFHELMDSISQDNRLLRLYTQNIDGLDTGLPHLGTKHPLVE
PWPKTVQLHGTITSMICSKCSWTADFDPNVDNETVIEVPVTPECPECIELDGVRAVAGKRSQGVGTLRPKIVLYNEPNPD
AEAIGQITEQDLLKKPDALVVVGTSLKIPGVRRMVREMSQAVHAARGCSVWMNIDDPSALSGREFESCFDLIVKGDCQIL
PQMLSDYEEERRLYEEEKQAQRRTKAEARAIRQKLALEKQVATAAALIAEEDRSDSSVASRSMSEGSAASSRLTSLEPMG
EVPTGATASSASTAGTGAMIAGRSKSTGVLSKRSGSRGAAAGAKRVCGGAAAAKKPRRVLGTGRKEGGAAGAKRSGKTES
ARKTEPTKPALVKAGRSQSAKAGKTQSLQSGKAVKDGPSKRRKKAVPPLDEKSPNTTVPLSISVDS

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0070403 NAD+ binding

Cellular Component

None predicted.