Protein
MCA_03974_1
Length
1,105 amino acids
Gene name: HST4
Description: NAD-dependent histone deacetylase HST4; member of the Sir2 family;
Browser: contigC:1671508-1674826+
RNA-seq: read pairs 596, FPKM 6.7, percentile rank 20.0% (100% = highest expression)
Protein function
| Annotation: | HST4 | NAD-dependent histone deacetylase HST4; member of the Sir2 family; | |
|---|---|---|---|
| KEGG: | K11121 | SIR2 | NAD-dependent histone deacetylase SIR2 [EC:3.5.1.-] |
| EGGNOG: | 0PHQG | FG00460.1 | SIR2 family histone deacetylase |
| SGD closest match: | S000002599 | HST4 | NAD-dependent histone deacetylase HST4 |
| CGD closest match: | CAL0000186930 | HST3 | NAD-dependent histone deacetylase HST3 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04568_1 | 61.06% | 434 | 3e-178 | MIA_04568_1 |
| A0A0J9XBY8_GEOCN | 51.70% | 412 | 4e-140 | Similar to Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylase OS=Geotrichum candidum GN=BN980_GECA08s03321g PE=4 SV=1 |
| UniRef50_A0A0J9XBY8 | 51.70% | 412 | 8e-137 | Similar to Saccharomyces cerevisiae YDR191W HST4 Member of the Sir2 family of NAD(+)-dependent protein deacetylase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XBY8_GEOCN |
| Q6CB00_YARLI | 44.52% | 420 | 3e-109 | YALI0C23034p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_C23034g PE=4 SV=1 |
| A0A060T5F6_BLAAD | 46.81% | 376 | 5e-108 | ARAD1B10868p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B10868g PE=4 SV=1 |
| HST4_YEAST | 39.54% | 349 | 5e-78 | NAD-dependent histone deacetylase HST4 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HST4 PE=1 SV=1 |
| A0A1E4TKK8_9ASCO | 40.62% | 352 | 1e-76 | Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_16213 PE=4 SV=1 |
| A0A167CEB9_9ASCO | 58.73% | 189 | 4e-61 | Hst4p OS=Sugiyamaella lignohabitans GN=HST4 PE=4 SV=1 |
| HST3_CANAL | 28.94% | 349 | 3e-43 | NAD-dependent histone deacetylase HST3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HST3 PE=3 SV=2 |
| A0A1E3PD12_9ASCO | 32.40% | 321 | 3e-42 | DHS-like NAD/FAD-binding domain-containing protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84477 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0073
Protein family membership
- Sirtuin family (IPR003000)
Domains and repeats
-
Domain
1
200
400
600
800
1000
1105
Detailed signature matches
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_03974_1 MNSDLEPPPKCPMIVTEIEASCSSQVVDSTSFNSDNTNKNPLVLEPLLPSHSPVKQEQTQEQYKDELAFTGASEVASSES SSSLNSTPTPTSSSSTPQLNNSKPHKTTKKAPGLSTRKPAIPKRTHDAPDIFDLFLALHNEETGKYEREKLRQIVRFKPP ATSKNSITNSQASTPSSQTPNGTINASDSQLSEKSLRLISSLNKISNSTNISVKESVAQILSSKNLQHEAQSNEKTQIQP IKDEKNDLDKSLSMSTEFSSDPVSFQDNSAPKIDEVESTIVKSEPSMENQEKIENGTDYDSDEEIPEDQLMASFKQDIAL LHHTFRYAKRIVIITGAGISVAAGIPDFRSTTGLFRLLRNDLKLKGNGANSGQQLFDASVVFSDDTALKNFHSTMCDLHS LCFSCKPTKFHLLMNQISKENRLLRLYTQNIDCLDTSLPDLYTARPLTRPWPKAIQLHGTIGSMNCTKCHWTSPFDPSKF RYTTYNKSDEDSTHNSNEKSAHSRNSPNSQDHNGNEDDTDEDEDGYNSDLETVIEHYPVPDCPECLESDSIRTIAGKRSQ GVGKLRPSIVLYNEPNPDSEAIGQVTEHDVTGKPDGLIVVGTSLKIPGVRRMVREMSQAVHAAKGCSIWMNIDDPSALSS REFESCFDLIVKGDCQLIPDILNDYEEEKRLYEEDKARERQLRMEAKILRQQLALERKAQKLLAKESKTNTKANTPSNSV SQDNSGATTPTADSTLASGTEKKKRTKKATADSTKKSSKTTPRSTLSKTISVKSEANETNTELKKTEGNSKTKTSEKPKT GTQKPKSEKSKISITEGGEIKPSSAKPKKAQKESSTAKKPRETASKMTKLKADNSVIKREKTSSKNKKVTKALSATVAPK NSKSKTPSIKKETNISTETSVKISEDLPNLEMHRTDSSSHLSLKDILNPELESEFQSSEVKGFKERHNSSGPPSPQKKRR RVSSEFDQKTKDNQVKIEPKHISPDNYLPVIHPPDNFNSIHSKDPNVEVNQSQGSLNSMTSTFESSQETTISTYSCNSDS ILNHLHHHNTFKEASLVIQNSQSGGLSSSSTIDEKNASEALMSLSNMFCENNTQPSVQTQEHITF
GO term prediction
Biological Process
None predicted.
Molecular Function
GO:0070403 NAD+ binding
Cellular Component
None predicted.