Protein
MIA_04560_1
Length
1,745 amino acids
Browser: contig06:362630-367911-
Protein function
| EGGNOG: | 0PK8U | SRB8 | Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex |
|---|---|---|---|
| SGD closest match: | S000000677 | SRB8 | Mediator of RNA polymerase II transcription subunit 12 |
| CGD closest match: | CAL0000179075 | SRB8 | Srb8p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_03710_1 | 37.084% | 1262 | 0.0 | MCA_03710_1 |
| A0A0J9X3V0_GEOCN | 38.397% | 711 | 8.16e-136 | Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA02s05323g PE=4 SV=1 |
| UniRef50_A0A0J9X3V0 | 38.397% | 711 | 1.67e-132 | Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3V0_GEOCN |
| A0A060T5S7_BLAAD | 27.839% | 722 | 1.39e-73 | ARAD1C07458p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C07458g PE=4 SV=1 |
| A0A167DE02_9ASCO | 55.507% | 227 | 4.80e-74 | Srb8p OS=Sugiyamaella lignohabitans GN=SRB8 PE=4 SV=1 |
| A0A1E3PQY2_9ASCO | 28.408% | 785 | 1.19e-67 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48501 PE=4 SV=1 |
| SRB8_YARLI | 49.321% | 221 | 3.37e-59 | Mediator of RNA polymerase II transcription subunit 12 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SRB8 PE=3 SV=2 |
| A0A1E4TKZ2_9ASCO | 42.920% | 226 | 1.18e-42 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86389 PE=4 SV=1 |
| A0A1D8PM80_CANAL | 35.865% | 237 | 2.47e-32 | Srb8p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SRB8 PE=4 SV=1 |
| SRB8_YEAST | 30.603% | 232 | 5.04e-25 | Mediator of RNA polymerase II transcription subunit 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRB8 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.1553
Predicted cleavage: 29
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1200
1400
1600
1745
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
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NON_CYTOPLASM... (N...)
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TRANSMEMBRANE (Tran...)
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mobidb-lite (disord...)
Protein sequence
>MIA_04560_1 MSRYGNLISSSIQNHHHQQHPAQPSQRPPSGSRSSLSSRDDLSSQRYVLAQPDGVQPLTDKKTVSNEYIYPDFFPWRKTA QEDDIVIKYLQKGYAVPPHVHEEYISACAPMTSILHQPPSLLALSYLMSNAMKVRERSHRFTSSSTFKPPPRFTLTEQKK EAWLRDLANPTIPLRKLSRTIPHGTRNRSLLEQCCNKNIPINRAVWFARCVGANELRGLKRKGAAAIASSNSASSSASAS ASVNPQASEAAWIREWTEQVTEYIEKIIRDFPSKSKQPPVLPTTTAATSSSPSNETSASSPHILNYSSPSPSSRPMVASP STSSPSASSPSSIRPTASFTSLKQQQHLQIQQHLPATDSWKAKLEYMLRLSEYLYAEDLLDKPLFLKWCISFFDSCRIQE LPSALLFLKPFWHSILHSPALSHTLALALIKHYAAISKNLELAHHPVCIYILSQIADYVKTLFILAPDIFVIPTHWKTMG PILSQIIKLNPSPTQGKELDELLTFISTRNENLIIADSCHVRALRNPHFLVIDALDRATLPFDWHAISQIVTANNLSERN VLQTAFEWATTTSRIGSGRLYACLSLVSYWRTPPYHWDVSTAFMDFLESIKSTSDYDMNNVYDLVAEFLDRDWFCISTYL RRLISSGVLFIPRMRDLAQAQLQIVANLPAQFFPADVRNQQIMLLKSLDLYDDHAETLKLQAVSQLLLKNLDFLSPEYPL FDPYESRDYNELSKTVCHQISELTHGSQIELSLWIINLLFEQLDRGFVPTISQFSLLQNTFEALRDPKSLYRAIEAIIPK ITSKPDHLYADSAPAFLGFLATSIRDNLFSFSAIADVNQIIYLLVVQYKSLKSNRNMPRGLSDLVQYAWYCIQLWYSQNS SKFYGLPPDAVPNINIDLRNELEDLLKPGGSGPGPGNVPAINTLSPMSDIAPDSMTSAANNELNDLFESDDIVDLQTMVF DSGSVPKYFSRVINKFLEACGYVQDSNTPKPCDSEEIRHQIKILQRLREADAVTFNKTLIKWLLEKTEVSLKYPLPTNLA YNPLVLTRVMLFLIVYDCISLVALADMFYQRQNQLEQQYAQALQLYQQQYAHAHGPAASTQNALHQIHLQSHHLDRQSST ETQESQDTQLDPASDQTLQLIKPAELPSLGPMRLLLDLVSVKFVHDEQIQLKASEKLALNMHRHIFQRANPVLYVKFIVH EIIRGSSSGTVLEENDASFPEISSFLLWLSIADIDKFIEFFTEPIIKSGNEKAIEVSNKITAHLLQTTTTTKIPKSTEAD NITDVASELVKLAAICNDFNIHLCQAHFHTVLYILQARITKPPPNPRLQRKPLPEEFYDRAVAQILQLVTINTARIEQYE PHIIGDIIVHLSLPFKSRLLHRAELAFFQQSLDLDDNGSHSKLAYLFELIDAIADSSQVNTLAVNRAEFADFLGRIITSA ESFIPSSTVPGDLDGKTDDDNEESAMSKSILLLGKIIMIHNATLANADDAYGLAGTILSGLSRLLHSQYIQHDKKNLSGF LLDVANAVRSSMTGLGVLGNGGSGGDDDVRPDVRSRQGSTVSSPAAAVGGVTPGATPAAVNAGITSRFGMDPSSVANSPV ASGAAMQLSTTASSTSSVNTPGRRMSFSMSASGAVMPGGAPETMLLDGPTADKSATAGPPDRGVYALERHYHQQELLRRL YLDEANNHDTYLADLILYHRATNRRTEMNVRAFDLLEDSSTKMQANDVAINLQLFEGIVEKSNPK
GO term prediction
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
Molecular Function
GO:0001104 RNA polymerase II transcription cofactor activity
Cellular Component
GO:0016592 mediator complex