Protein
MCA_03710_1
Length
1,739 amino acids
Gene name: SRB8
Description: Mediator of RNA polymerase II transcription subunit 12
Browser: contigC:841106-846426+
RNA-seq: read pairs 1165, FPKM 8.3, percentile rank 22.9% (100% = highest expression)
Protein function
| Annotation: | SRB8 | Mediator of RNA polymerase II transcription subunit 12 | |
|---|---|---|---|
| EGGNOG: | 0PK8U | SRB8 | Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex |
| SGD closest match: | S000000677 | SRB8 | Mediator of RNA polymerase II transcription subunit 12 |
| CGD closest match: | CAL0000179075 | SRB8 | Srb8p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04560_1 | 37.24% | 1262 | 0.0 | MIA_04560_1 |
| A0A0J9X3V0_GEOCN | 32.32% | 1216 | 5e-152 | Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA02s05323g PE=4 SV=1 |
| UniRef50_A0A0J9X3V0 | 32.32% | 1216 | 1e-148 | Uncharacterized protein n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3V0_GEOCN |
| A0A167DE02_9ASCO | 38.84% | 690 | 2e-124 | Srb8p OS=Sugiyamaella lignohabitans GN=SRB8 PE=4 SV=1 |
| A0A060T5S7_BLAAD | 24.54% | 1198 | 2e-72 | ARAD1C07458p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C07458g PE=4 SV=1 |
| A0A1E3PQY2_9ASCO | 48.63% | 255 | 1e-62 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48501 PE=4 SV=1 |
| SRB8_YARLI | 50.45% | 222 | 4e-61 | Mediator of RNA polymerase II transcription subunit 12 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=SRB8 PE=3 SV=2 |
| A0A1E4TKZ2_9ASCO | 27.29% | 667 | 7e-47 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_86389 PE=4 SV=1 |
| A0A1D8PM80_CANAL | 28.95% | 304 | 2e-29 | Srb8p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SRB8 PE=4 SV=1 |
| SRB8_YEAST | 29.91% | 224 | 2e-26 | Mediator of RNA polymerase II transcription subunit 12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SRB8 PE=1 SV=2 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.6157
Predicted cleavage: 21
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
200
400
600
800
1000
1200
1400
1600
1739
Detailed signature matches
no IPR
Unintegrated signatures
-
mobidb-lite (disord...)
Protein sequence
>MCA_03710_1 MSNRRYGGSNNLSPSISQRSAGYSKSYSSTTSRDKLATQRYHLTSPDGIPPLVNKPNNLGQLIYPDFFPWQKTPAEDENV LKYLHKGYQYSSTLVDETLSEKTRMVMSLKHEATRSRAFIALSYVMSNSMRMIEKSHRFTSSSTFKPPPRVTLTELTKEA WLRDLANPSVPLRRLSRTIPHGTRNRSLLEQCCNKEIPISRAVWFARCVGANELRGLRRKNVYHTGQSSEAAWVREWTEQ VTEYIEKIIKDGTKPMNSNLNNNNTHSSTSPYVHDSPVNSSPIASSPIAHNLATKSSISSVGSSSSQPSQQLSSNKPPQS PVSTSPSLPNVPTPRTSLASFHSSSKQSNTPQVPWKSKMEYMLRLSSYLYDEDLLDKRVFLQWCVNFCETCKLHELPAAL LYLEAYWSSIIRSTFFVQSLALGLLRHYSALSSQPNSKHPLILNLCEKISQHVKSIFLLFPDIFVIPNDWKTLGPALATI LKGQSEDLDQLFSFISKRNENLIVSDSSIVRTLRNPTFFIIDALDNAKLPFGWKTLTQTILSNSINESEALKTTFEWATT NSRSGSERLYTCLSLVTFWHEQNQWNISNSFINFLEGVTNEKDYSMNNIYDLLTELLDRDWFSISDYFRRLISSGVLQIP RFRNSLDAQLKVLANIPVQFFDSSYRNQQVMILQKFNKYDPSETKKLESVAQELTRIMDFISSEYDISSEDLEKEYFELN PSICQTIESFSKGLQLELSLWLFELLESKIKDGLILTISQFSLVQNVFEKLRDLKSVYRVVELTIPKATNSALLSFLSNF VRDNLVILSALADVSQIIHLLVNQFKGLKTKSKVPRGLWDLANFALHKMDLSNIPDMRFNLEQLVNPGMQHQSSLYQYLQ QPAQQYQNQQQDITTLSPMSDSLPESLSTVSQEFSNLLNLSNGSILKEQLDPSSTTKYFTIITTKLLEGFHSSPQLLDPT NVRQFTRVLQYLRENNTLLCDKMLSKWLKTNIEVFCQNPKGFTKILLFLIIYECISLEKVAEIVIEGEPNLTDIFSETFS TNGTTRASTGTLDNGIKTNGYSMRQPQSQRSVVEQHEPQPPRTISFKTFQLTNIVLNLVTSEFFEDVNLRASEKLALDMH CKIFEKTCPLLLVKFIDFEVLGSCSDYENNPNVKEIISAAKLPDSSFKVLSEFLLGLSVANINIFIDQFSEPLIKSSNPA AILLSRDITAHLLKLQPYNGSEQCISEEEMVKNEITKLANVCNNFNVHLCQVHLRTSLCAMQTNSQHSQTEFSTLVADII INMISNTEALDNLNITPRILGDLLIHLSKPFKSKLLYKSEVLFLTSSNLLERKNKPEAKTMDLDTSQAEDHSMKSEKSTS NIQDDSKEDGDQVPPLLSYLYEIIDAVADSVEVNIFSTNKFDAMGYLTLLVKLSEAYNPLLENQINGESNASSNADTSIV NQASAPPPPGKDQSKSKSSLLPDKSTLGKAILLFGKIVMIHSSELPTIQGYEVLLDKLVTYLARLLNTQFVKGCNDLFGL IYDIFNTLKNRHKDGDEDMVNTGVSIVGNSAKQLAQIKNSLSDSSRTGVSSSSPNTSGLSAFGIAASSAATSPNNTLFSS TSSSSASQKSTNAFFNMERTAPLLSSQDNSSNGSSSDFNSMFPGVSNNAGLESSMPTSFGLQQYQYYQQRKLLRELNLKS AQEEDSYLTDLKLYNRKTGKLEELGAGPFDLLEESNPKMQVNDVAINLALFDGLLEKPL
GO term prediction
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
Molecular Function
GO:0001104 RNA polymerase II transcription cofactor activity
Cellular Component
GO:0016592 mediator complex