Protein

MIA_04559_1

Length
1,031 amino acids

Browser: contig06:359218-362314+

Protein function

EGGNOG:0PF86MSH2DNA mismatch repair protein Msh2
SGD closest match:S000005450MSH2DNA mismatch repair protein MSH2
CGD closest match:CAL0000196306MSH2Mismatch repair ATPase

Protein alignments

%idAln lengthE-value
MCA_03711_161.532%11100.0MCA_03711_1
A0A0J9X637_GEOCN62.173%10310.0Similar to Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process OS=Geotrichum candidum GN=BN980_GECA04s01550g PE=3 SV=1
A0A1E3PQS8_9ASCO56.780%10250.0DNA mismatch repair protein msh-2 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69419 PE=3 SV=1
A0A167DCW4_9ASCO55.849%10600.0Mismatch repair ATPase MSH2 OS=Sugiyamaella lignohabitans GN=MSH2 PE=3 SV=1
UniRef50_A0A167DCW455.849%10600.0Mismatch repair ATPase MSH2 n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A167DCW4_9ASCO
A0A060TBS9_BLAAD53.899%10260.0ARAD1B17798p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B17798g PE=3 SV=1
A0A1E4TE51_9ASCO50.252%9910.0Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31131 PE=3 SV=1
MSH2_YEAST45.739%10210.0DNA mismatch repair protein MSH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH2 PE=1 SV=2
Q6C3F6_YARLI45.870%10290.0YALI0F00154p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F00154g PE=3 SV=1
Q5A102_CANAL39.424%10070.0Mismatch repair ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MSH2 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0257

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 900 1031

Detailed signature matches

  1. Family IPR011184
    DNA mismatch repair Msh2-type
    1. PIRSF005813 (MSH2)
  2. Domain IPR007695
    DNA mismatch repair protein MutS-like, N-terminal
    1. PF01624 (MutS_I)
  3. Domain IPR016151
    DNA mismatch repair protein MutS, N-terminal
    1. G3DSA:3.40.11...
  4. Domain IPR007860
    DNA mismatch repair protein MutS, connector domain
    1. G3DSA:3.30.42...
    2. PF05188 (MutS_II)
  5. Domain IPR007696
    DNA mismatch repair protein MutS, core
    1. SM00533 (DNAend)
    2. SSF48334 (DNA repai...)
    3. PF05192 (MutS_III)
  6. Domain IPR007861
    DNA mismatch repair protein MutS, clamp
    1. PF05190 (MutS_IV)
  7. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  8. Domain IPR000432
    DNA mismatch repair protein MutS, C-terminal
    1. PF00488 (MutS_V)
    2. SM00534 (mutATP5)
    3. PS00486 (DNA_MISMAT...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.14...
  3. G3DSA:3.40.50...

Protein sequence

>MIA_04559_1
MASRPDFKLDKGDENGFLVFYRGLVNKDKKDATEGTESKVIRIFERGDDYSAHYKDAIYIAENVYRTLSVVKYLGNSPFE
EFEKGLPSVSMSATVFQTFLKDALFNQGLKVEIYAAAAGSSNRWSVVKQASPGNLLDVEDLLGNQIDQKPIVIALKVQAK
KIDSIGGTIGGAPAGGSAAAPSGSSGGSASGRAVGICFIDCTAREIGVFEFFDNDLYSNLESVLIQLGVKECVLPAFNST
PTPGSALSPEALDLTKVTELLDRCDIAISPRKSSDFNTRDIEQDLGKLLSPTSIPISALPALNSACAMSATAALIKYLEL
MSQPEMFGHFSIVQHDLSQYMRLDASAIKALNLMPGPRDGTSTSSSGPNASKSMSLFGLLNRCKTAAGTRLLGQWLKQPL
MDIEEIQSRHTLVEAFVNDTVLRQTLQTDCLNAIPDISRLVRKLQRNAASLEDVVRIYQMVIRLPSLLTALDEYEELEGS
DQKAKTIITELYTSRIKSCYQNLEKLQELVETTVDLEALDNHEFIIKPDFDDRLKEIRDRLAELRDQIDDEHIRASDDLN
MDREKKLKLENHHVFGWCFRLTRTDASCLRSHSGYIELSTQKAGIYFTSRSLKSLSQEFNDLSNEYSKTQSGLVREVVGI
VATYAPVLEALSLVLAHLDVIVSFAQAAVFAPIPYVRPVMHPRGSGRTILKEARHPCLEAQDDMRFIPNDVTLVRDESEF
LIITGPNMGGKSTYIRQIGVIALMAQVGSFVPCAEGGAELTVYDSILARVGAGDSQLKGVSTFMAEMLETATILKSATRD
SLIVIDELGRGTSTYDGFGLAWAISEHIVREIGCFGMFATHFQELTGLADLYPKSVCNLHVVAHVHEVDTRLAMETSHRA
APGVTQDKDSDVFSSPSITLLYKVEPGVSDQSFGIHVAEVVKFPPKVIRMAKRKALELEDFEREDDGSTQGADSTKQLKA
KFSNEQIHDGSEMLRGLLKDWANAVGPLDEGSGSQLTSQTILAKLKDVLDKDHFKGKMDSNPFVSALMAQL

GO term prediction

Biological Process

GO:0006298 mismatch repair

Molecular Function

GO:0005524 ATP binding
GO:0030983 mismatched DNA binding

Cellular Component

None predicted.