Protein
MCA_03711_1
Length
1,064 amino acids
Gene name: MSH2
Description: DNA mismatch repair protein MSH2
Browser: contigC:846557-849752-
RNA-seq: read pairs 1530, FPKM 17.8, percentile rank 38.1% (100% = highest expression)
Protein function
| Annotation: | MSH2 | DNA mismatch repair protein MSH2 | |
|---|---|---|---|
| KEGG: | K08735 | MSH2 | DNA mismatch repair protein MSH2 |
| EGGNOG: | 0PF86 | MSH2 | DNA mismatch repair protein Msh2 |
| SGD closest match: | S000005450 | MSH2 | DNA mismatch repair protein MSH2 |
| CGD closest match: | CAL0000196306 | MSH2 | Mismatch repair ATPase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04559_1 | 61.62% | 1110 | 0.0 | MIA_04559_1 |
| A0A0J9X637_GEOCN | 58.43% | 1068 | 0.0 | Similar to Saccharomyces cerevisiae YOL090W MSH2 Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process OS=Geotrichum candidum GN=BN980_GECA04s01550g PE=3 SV=1 |
| A0A167DCW4_9ASCO | 54.09% | 1087 | 0.0 | Mismatch repair ATPase MSH2 OS=Sugiyamaella lignohabitans GN=MSH2 PE=3 SV=1 |
| UniRef50_A0A167DCW4 | 54.09% | 1087 | 0.0 | Mismatch repair ATPase MSH2 n=2 Tax=Saccharomycetales TaxID=4892 RepID=A0A167DCW4_9ASCO |
| A0A1E3PQS8_9ASCO | 55.33% | 1041 | 0.0 | DNA mismatch repair protein msh-2 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_69419 PE=3 SV=1 |
| A0A060TBS9_BLAAD | 50.71% | 1053 | 0.0 | ARAD1B17798p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B17798g PE=3 SV=1 |
| A0A1E4TE51_9ASCO | 50.20% | 976 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_31131 PE=3 SV=1 |
| MSH2_YEAST | 45.71% | 1026 | 0.0 | DNA mismatch repair protein MSH2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSH2 PE=1 SV=2 |
| Q6C3F6_YARLI | 45.16% | 1003 | 0.0 | YALI0F00154p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F00154g PE=3 SV=1 |
| Q5A102_CANAL | 40.27% | 961 | 0.0 | Mismatch repair ATPase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MSH2 PE=3 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0227
Protein family membership
- DNA mismatch repair Msh2-type (IPR011184)
Domains and repeats
-
Domain
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Domain
1
100
200
300
400
500
600
700
800
900
1000
1064
Detailed signature matches
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PIRSF005813 (MSH2)
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-
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PF01624 (MutS_I)
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-
-
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PF05188 (MutS_II)
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PF05190 (MutS_IV)
-
-
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SSF52540 (P-loop co...)
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no IPR
Unintegrated signatures
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-
-
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cd03285 (ABC_MSH2_euk)
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mobidb-lite (disord...)
Residue annotation
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Walker A/P-loop cd...
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ATP binding site c...
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Q-loop/lid cd03285
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ABC transporter si...
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Walker B cd03285
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D-loop cd03285
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H-loop/switch regi...
Protein sequence
>MCA_03711_1 MSSRPELKLDKGDETGFIAFFRALTKSLASSSSDNINNKTILIFDRGDYYTAHGHDAIYIAQNVYRTLSVVKYLGNRAFS TEFEKGLPSVSLSQLVFQNFLKDALLNQGLKVQIYAQNSSNSHSSNILNSWKVVKQASPGNLHDVEDLLDTQVVDSNPVV IALKVLAKADSRTVGVCFMNSSPTSAPTSLSELSSEEAVKGSMATKEIGIFEFADNDLFSNLESLVIQLGVKECILPVSS SSKQPGDNADLLKIVELLNRCDVTITERKSSDFNTRDVEQDLSKLLKRPSDSSALSVSALPEVSLTNAMAATAALIKYLG VMSIPDESFGQYQLVRHDLSQFMKLDSAAIKALNLMPTARDGSNKNMSLFGLLNHCKTAAGTRLLGQWLKQPLMDLEEIK NRQSLVGAFLEDSILKQTLQEECLKSIPDIGRMLRKFQKQSATLEDVVRIYQMVIKMPDIIVALEGYESQGNDEEYNIDS EEKQKPVGTIIKELYTDPIKLAYGSLEKLQELVETTVDLEALDRHEFIIKPDFDERLQVIHSRLAELESLIRDEHLRAGD DLGMDPERKLKLENHHVYGWSFRLTRTDASCLRTHKGYIELSTQKAGVYFTSRALKSLSEESSELSTEYNKTQSSLVKEV VEIVSTYAPVLEHLSMTLAHLDVIVSFAHAASLAPIPYTRPIVHPRGTGNTILKEARHPCLEMQDDVSFIPNDVSLVRGK SEFLIITGPNMGGKSTYIRQIGVIALMAQIGSYVPCDEGSELCIFDCILARVGAGDSQLKGVSTFMAEMLETASILKTAT RESLIVIDELGRGTSTYDGFGLAWAITEHIVKKISCFGMFATHFHELTGLAKLYPNQVENLHVLAHVGEVDNRLAMETSH NPLSTNGKAGDEFQSPSITLLYKVEPGISDQSFGIHVAEVVKFPPKVIRMAKRKAFELEDFERDEEGSSTNELEILSLPS SQDGSAPLKKTKTKPQFSEAEIHEGSELLKQVLKAWMKSLSKDGSPALDDESSKKNGDNKSDEFMFDHLSKTQILESLKS VVEEGDWKAKLDANPFVQSIMNQL
GO term prediction
Biological Process
GO:0006298 mismatch repair
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
Cellular Component
None predicted.