Protein

MIA_04531_1

Length
331 amino acids

Browser: contig06:270342-271390+

Protein function

EGGNOG:0PGH8FG02504.1Malate dehydrogenase
SGD closest match:S000001568MDH1Malate dehydrogenase, mitochondrial
CGD closest match:CAL0000181993MDH1Malate dehydrogenase, cytoplasmic

Protein alignments

%idAln lengthE-value
MCA_05890_184.211%3040.0MCA_05890_1
A0A0J9X9Q8_GEOCN79.139%3023.06e-170Similar to Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA06s01693g PE=3 SV=1
A0A060T884_BLAAD77.152%3021.28e-166ARAD1D04884p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04884g PE=4 SV=1
UniRef50_A0A060T88477.152%3023.16e-163ARAD1D04884p n=2 Tax=saccharomyceta TaxID=716545 RepID=A0A060T884_BLAAD
Q6C5X9_YARLI75.166%3025.29e-163YALI0E14190p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14190g PE=3 SV=2
A0A167FGN5_9ASCO73.786%3092.90e-160Malate dehydrogenase MDH1 OS=Sugiyamaella lignohabitans GN=MDH1 PE=3 SV=1
A0A1E4TLW6_9ASCO71.037%3285.10e-160Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1347 PE=3 SV=1
A0A1E3PIQ8_9ASCO62.832%3391.45e-139Malate dehydrogenase, NAD-dependent OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47000 PE=3 SV=1
MDHC_CANAL59.581%3341.19e-124Malate dehydrogenase, cytoplasmic OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDH1 PE=1 SV=2
MDHM_YEAST55.591%3132.82e-107Malate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDH1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3804

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 331

Detailed signature matches

  1. Family IPR001557
    L-lactate/malate dehydrogenase
    1. PIRSF000102 (Lac_ma...)
  2. Family IPR010097
    Malate dehydrogenase, type 1
    1. TIGR01772
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR001236
    Lactate/malate dehydrogenase, N-terminal
    1. PF00056 (Ldh_1_N)
  5. Domain IPR015955
    Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
    1. SSF56327 (LDH C-ter...)
  6. Domain IPR022383
    Lactate/malate dehydrogenase, C-terminal
    1. PF02866 (Ldh_1_C)
  7. SITE IPR001252
    Malate dehydrogenase, active site
    1. PS00068 (MDH)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.11...
  3. cd01337 (MDH_glyoxy...)

Residue annotation

  1. NAD binding site c...
  2. dimerization inter...
  3. Substrate binding ...

Protein sequence

>MIA_04531_1
MVKAVVAGAAGGIGQPLSLLLKLSPYVTDLALYDVVNSPGVAADLSHISTEGKVEGFLPADGGLEKALTGADIVVIPAGI
PRKPGMTRDDLFKINAGIVRDLIEGVAKYSPKAFVLIISNPVNSTVPIAAEVLKKAGVFDPKKLFGVTTLDVVRAQTFVS
TVIGDKNPAKYNVPVIGGHSGETIVPLVSLSEPKVDVPEDKLPELVKRIQFGGDEVVQAKNGAGSATLSMAYAGFRFAEA
VLKGAAGEKNIVEPSFVYLEGIEGAEEIKKAVGVDFFSVPVELGPGGATKLINPLEKVTPYEKGLIDVAISGLSGNISKG
VEFITAPAESK

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0006108 malate metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016615 malate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase activity

Cellular Component

None predicted.