Protein

MCA_05890_1

Length
338 amino acids

Browser: contigD:2657994-2659328+

RNA-seq: read pairs 99815, FPKM 3638.1, percentile rank 98.9% (100% = highest expression)

Protein function

KEGG:K00026MDH2 malate dehydrogenase [EC:1.1.1.37]
EGGNOG:0PGH8FG02504.1Malate dehydrogenase
SGD closest match:S000001568MDH1Malate dehydrogenase, mitochondrial
CGD closest match:CAL0000181993MDH1Malate dehydrogenase, cytoplasmic

Protein alignments

%idAln lengthE-value
MIA_04531_184.21%3040.0MIA_04531_1
A0A0J9X9Q8_GEOCN83.00%3003e-177Similar to Saccharomyces cerevisiae YKL085W MDH1 Mitochondrial malate dehydrogenase OS=Geotrichum candidum GN=BN980_GECA06s01693g PE=3 SV=1
Q6C5X9_YARLI78.48%3024e-167YALI0E14190p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14190g PE=3 SV=2
A0A060T884_BLAAD75.50%3022e-162ARAD1D04884p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D04884g PE=4 SV=1
UniRef50_A0A060T88475.50%3025e-159ARAD1D04884p n=2 Tax=saccharomyceta TaxID=716545 RepID=A0A060T884_BLAAD
A0A167FGN5_9ASCO73.87%3101e-158Malate dehydrogenase MDH1 OS=Sugiyamaella lignohabitans GN=MDH1 PE=3 SV=1
A0A1E4TLW6_9ASCO70.12%3282e-155Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1347 PE=3 SV=1
A0A1E3PIQ8_9ASCO63.95%3441e-139Malate dehydrogenase, NAD-dependent OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_47000 PE=3 SV=1
MDHC_CANAL58.68%3347e-120Malate dehydrogenase, cytoplasmic OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MDH1 PE=1 SV=2
MDHM_YEAST53.38%3116e-99Malate dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MDH1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3141

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 338

Detailed signature matches

  1. Family IPR001557
    L-lactate/malate dehydrogenase
    1. PIRSF000102 (Lac_ma...)
  2. Family IPR010097
    Malate dehydrogenase, type 1
    1. TIGR01772
  3. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  4. Domain IPR001236
    Lactate/malate dehydrogenase, N-terminal
    1. PF00056 (Ldh_1_N)
  5. Domain IPR015955
    Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
    1. SSF56327 (LDH C-ter...)
  6. Domain IPR022383
    Lactate/malate dehydrogenase, C-terminal
    1. PF02866 (Ldh_1_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.11...
  3. cd01337 (MDH_glyoxy...)

Residue annotation

  1. NAD binding site c...
  2. dimerization inter...
  3. Substrate binding ...

Protein sequence

>MCA_05890_1
MVKAVVAGAAGGIGQPLSLLLKLSPYVDDLALYDVVNSPGVAADLSHISTKGEVVGHLPADGGLEKALTGADIVVIPAGI
PRKPGMTRDDLFKINAGIVRDLIEGVAKFCPKAFVLIISNPVNSTVPIAAEVLKKAGVFDPKKLFGVTTLDVVRAQTFTA
SVVGASDPSKYNIPVVGGHSGETIVPLLSLTTPSTEVPADKLDALVKRIQFGGDEVVQAKNGGGSATLSMAYAGYRFAEA
VLKGAAGEKNIVEPSYVFLDGIEGGEEIKKAVGVDFFSVPVELGTEGASKLINPLTKINDHEKKLIEVAVQGLSGNITKG
VEFITNPSKKSLAFYYLD

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0006099 tricarboxylic acid cycle
GO:0019752 carboxylic acid metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0030060 L-malate dehydrogenase activity

Cellular Component

None predicted.