MIA_04530_1

Protein

Length

485 amino acids

Protein function

EGGNOG:	0PIRI	ADE13	adenylosuccinate lyase
SGD closest match:	S000004351	ADE13	Adenylosuccinate lyase
CGD closest match:	CAL0000175023	ADE13	Adenylosuccinate lyase

Protein alignments

	%id	Aln length
MCA_05889_1	86.749%	483	MCA_05889_1
A0A0J9XKL4_GEOCN	86.722%	482	Adenylosuccinate lyase OS=Geotrichum candidum GN=BN980_GECA25s00296g PE=3 SV=1
A0A1E3PFH5_9ASCO	85.477%	482	Adenylosuccinate lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84083 PE=3 SV=1
A0A167FG42_9ASCO	83.789%	475	Adenylosuccinate lyase OS=Sugiyamaella lignohabitans GN=ADE13 PE=3 SV=1
Q6CE97_YARLI	84.000%	475	Adenylosuccinate lyase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B17402g PE=3 SV=1
A0A060THS4_BLAAD	83.368%	475	Adenylosuccinate lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40216g PE=3 SV=1
A0A1D8PT56_CANAL	81.356%	472	Adenylosuccinate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE13 PE=3 SV=1
UniRef50_G8YCL2	79.289%	478	Adenylosuccinate lyase n=29 Tax=Opisthokonta TaxID=33154 RepID=G8YCL2_PICSO
PUR8_YEAST	79.167%	480	Adenylosuccinate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE13 PE=1 SV=1
A0A1E4TLY6_9ASCO	81.023%	469	Adenylosuccinate lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30826 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1165
Predicted cleavage: 18

Protein family membership

Fumarate lyase family (IPR000362)
- Adenylosuccinate lyase (IPR004769)

Domains and repeats

Domain
6 - 305
Fumarase/histidase, N-terminal (IPR024083)
Fumarate lyase, N-terminal (IPR022761)
376 - 460
Adenylosuccinate lyase C-terminal (IPR019468)
Domain
11 - 462
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 450 485

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  150 - 168
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  287 - 303
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  244 - 271
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR004769

Adenylosuccinate lyase
1. TIGR00928
  
  13 - 460
  
  TIGRFAMs
  TIGR00928 (TIGR00928)
IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  6 - 108
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  11 - 462
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  41 - 305
  
  Pfam
  PF00206 (Lyase_1)
IPR019468

Adenylosuccinate lyase C-terminal
1. SM00998 (ADSL_C_2)
  
  376 - 460
  
  SMART
  SM00998 (ADSL_C_2)
2. PF10397 (ADSL_C)
  
  377 - 459
  
  Pfam
  PF10397 (ADSL_C)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  287 - 296
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

365 - 485

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.20...

109 - 480

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
NON_CYTOPLASM... (N...)

1 - 342

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TRANSMEMBRANE (Tran...)

343 - 364

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd03302 (Adenylsucc...)

13 - 451

CDD
cd03302 (Adenylsuccinate_lyase_2)

Residue annotation

tetramer interface...

27S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

28L

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

86D

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

95G

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

104I

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

105I

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

107L

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

108G

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

156W

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

157T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

158H

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

159F

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

160Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

161P

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

163Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

169K

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

170R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

173L

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

176Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

177E

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

183R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

184N

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

200T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

201T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

202G

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

203T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

206S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

235Y

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

237V

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

238T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

245K

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

249D

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

256S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

263K

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

267D

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

269R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

270L

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

272A

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

273N

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

295R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

296N

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

301E

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

305S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

308R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

309H

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

311Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

312S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

315Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

316D

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

319S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

320T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

324Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

325W

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

326F

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

327E

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

328R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

329T

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

330L

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

334A

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

335I

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

337R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

342S

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

382E

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

386M

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

389V

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

395R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

396Q

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

449V

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)

451R

tetramer interface
27S, 28L, 86D, 95G, 104I, 105I, 107L, 108G, 156W, 157T, 158H, 159F, 160Q, 161P, 163Q, 169K, 170R, 173L, 176Q, 177E, 183R, 184N, 200T, 201T, 202G, 203T, 206S, 235Y, 237V, 238T, 245K, 249D, 256S, 263K, 267D, 269R, 270L, 272A, 273N, 295R, 296N, 301E, 305S, 308R, 309H, 311Q, 312S, 315Q, 316D, 319S, 320T, 324Q, 325W, 326F, 327E, 328R, 329T, 330L, 334A, 335I, 337R, 342S, 382E, 386M, 389V, 395R, 396Q, 449V, 451R
CDD
cd03302 (Adenylsuccinate_lyase_2)
active site cd03302

85H

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

106H

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

158H

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

240Q

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

294K

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

296N

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

301E

active site
85H, 106H, 158H, 240Q, 294K, 296N, 301E
CDD
cd03302 (Adenylsuccinate_lyase_2)

Protein sequence

>MIA_04530_1
MSSSTYDKYQTPLSSRYASKEMSELFSLRNRYSTWRKLWLNLAIAEKELGISAISQEAIDQMKTHIAISDEEIEAATKQE
AIVRHDVMSHVHVFGETCPAAAGIIHLGATSCFVTDNADLIFLRDGFDILIPKLVNVIDRLSDFAIKYKDMPVLGWTHFQ
PAQLTTVGKRATLWIQELLWDLRNIVRARNDLGLRGVKGTTGTQGSFLALFHGNHDKVEALDDRVVELLGFDYAYPVTGQ
TYSRKIDVDVLAPLASLGVSAHKFATDIRLLANLKEVEEPFESTQIGSSAMAYKRNPMRSERVCSLSRHLQSLFQDATST
ASIQWFERTLDDSAIRRVSLPSAFLTADIVLSTLLNIVSGLVVYPKVIERRISAELPFMATENIIMAMVEKGGDRQECHE
KIRVLSHQAAAVVKQQGGDNDLIERVKKDSYFEPVHAHLDTLLDPSTFVGRAPQQTEKFVKVTVAKALSGLEHHINKKEE
SKLSV

GO term prediction

Biological Process

GO:0009152 purine ribonucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features