MCA_05889_1

Protein

Length

484 amino acids

Gene name: ADE13

Description: Adenylosuccinate lyase

Browser: contigD:2654899-2656354-

RNA-seq: read pairs 37961, FPKM 967.1, percentile rank 96.5% (100% = highest expression)

Protein function

Annotation:		ADE13	Adenylosuccinate lyase
KEGG:	K01756	purB	adenylosuccinate lyase [EC:4.3.2.2]
EGGNOG:	0PIRI	ADE13	adenylosuccinate lyase
SGD closest match:	S000004351	ADE13	Adenylosuccinate lyase
CGD closest match:	CAL0000175023	ADE13	Adenylosuccinate lyase

Protein alignments

	%id	Aln length
MIA_04530_1	86.75%	483	MIA_04530_1
A0A167FG42_9ASCO	82.84%	472	Adenylosuccinate lyase OS=Sugiyamaella lignohabitans GN=ADE13 PE=3 SV=1
A0A1E3PFH5_9ASCO	83.40%	476	Adenylosuccinate lyase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84083 PE=3 SV=1
A0A1D8PT56_CANAL	81.33%	482	Adenylosuccinate lyase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADE13 PE=3 SV=1
A0A0J9XKL4_GEOCN	82.45%	473	Adenylosuccinate lyase OS=Geotrichum candidum GN=BN980_GECA25s00296g PE=3 SV=1
Q6CE97_YARLI	81.99%	472	Adenylosuccinate lyase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B17402g PE=3 SV=1
A0A060THS4_BLAAD	80.79%	479	Adenylosuccinate lyase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D40216g PE=3 SV=1
UniRef50_G8YCL2	79.58%	475	Adenylosuccinate lyase n=29 Tax=Opisthokonta TaxID=33154 RepID=G8YCL2_PICSO
PUR8_YEAST	78.69%	474	Adenylosuccinate lyase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADE13 PE=1 SV=1
A0A1E4TLY6_9ASCO	78.46%	469	Adenylosuccinate lyase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_30826 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1065
Predicted cleavage: 32

Protein family membership

Fumarate lyase family (IPR000362)
- Adenylosuccinate lyase (IPR004769)

Domains and repeats

Domain
5 - 304
Fumarase/histidase, N-terminal (IPR024083)
Fumarate lyase, N-terminal (IPR022761)
375 - 459
Adenylosuccinate lyase C-terminal (IPR019468)
Domain
10 - 461
L-Aspartase-like (IPR008948)

1 50 100 150 200 250 300 350 400 450 484

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  243 - 270
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  149 - 167
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  286 - 302
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR004769

Adenylosuccinate lyase
1. TIGR00928
  
  12 - 459
  
  TIGRFAMs
  TIGR00928 (TIGR00928)
IPR024083

Fumarase/histidase, N-terminal
1. G3DSA:1.10.27...
  
  5 - 107
  
  GENE3D
  G3DSA:1.10.275.10 (G3DSA:1.10.275.10)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  10 - 461
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  49 - 304
  
  Pfam
  PF00206 (Lyase_1)
IPR019468

Adenylosuccinate lyase C-terminal
1. SM00998 (ADSL_C_2)
  
  375 - 459
  
  SMART
  SM00998 (ADSL_C_2)
2. PF10397 (ADSL_C)
  
  376 - 458
  
  Pfam
  PF10397 (ADSL_C)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  286 - 295
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

CYTOPLASMIC_D... (C...)

364 - 484

PHOBIUS
CYTOPLASMIC_DOMAIN (Cytoplasmic domain)
G3DSA:1.20.20...

108 - 479

GENE3D
G3DSA:1.20.200.10 (G3DSA:1.20.200.10)
NON_CYTOPLASM... (N...)

1 - 341

PHOBIUS
NON_CYTOPLASMIC_DOMAIN (Non cytoplasmic domain)
TRANSMEMBRANE (Tran...)

342 - 363

PHOBIUS
TRANSMEMBRANE (Transmembrane region)
cd03302 (Adenylsucc...)

12 - 450

CDD
cd03302 (Adenylsuccinate_lyase_2)

Residue annotation

tetramer interface...

26S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

27L

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

85D

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

94G

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

103I

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

104I

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

106L

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

107G

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

155F

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

156T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

157H

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

158F

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

159Q

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

160P

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

162Q

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

168K

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

169R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

172L

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

175Q

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

176E

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

182R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

183N

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

199T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

200T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

201G

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

202T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

205S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

234Y

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

236C

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

237T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

244K

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

248D

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

255S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

262K

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

266D

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

268R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

269L

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

271A

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

272N

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

294R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

295N

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

300E

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

304S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

307R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

308H

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

310S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

311S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

314L

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

315D

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

318G

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

319T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

323Q

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

324W

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

325F

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

326E

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

327R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

328T

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

329L

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

333A

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

334I

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

336R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

341S

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

381E

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

385M

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

388V

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

394R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

395Q

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

448V

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)

450R

tetramer interface
26S, 27L, 85D, 94G, 103I, 104I, 106L, 107G, 155F, 156T, 157H, 158F, 159Q, 160P, 162Q, 168K, 169R, 172L, 175Q, 176E, 182R, 183N, 199T, 200T, 201G, 202T, 205S, 234Y, 236C, 237T, 244K, 248D, 255S, 262K, 266D, 268R, 269L, 271A, 272N, 294R, 295N, 300E, 304S, 307R, 308H, 310S, 311S, 314L, 315D, 318G, 319T, 323Q, 324W, 325F, 326E, 327R, 328T, 329L, 333A, 334I, 336R, 341S, 381E, 385M, 388V, 394R, 395Q, 448V, 450R
CDD
cd03302 (Adenylsuccinate_lyase_2)
active site cd03302

84H

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

105H

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

157H

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

239Q

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

293K

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

295N

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

300E

active site
84H, 105H, 157H, 239Q, 293K, 295N, 300E
CDD
cd03302 (Adenylsuccinate_lyase_2)

Protein sequence

>MCA_05889_1
MSAKYDSYQTPLSSRYASKEMSHLFSLRNRFSTWRKLWYNLAIAERELGIEAVTQEAIDQMAKHLEITDEEIEAATVEEA
RVRHDVMSHVHVFGETCPAAAPIIHLGATSCFVTDNADLIFLRDGFDILIPKLVNVIDRLSDFVLKYKDLPTLGFTHFQP
AQLTTVGKRATLWLQELLWDLRNLQRARNDLGLRGVKGTTGTQASFLTLFHGNHDKVDQLDERVVELLGFDYAYPCTGQT
YSRKIDIDCLAPLASLGASAHKLATDIRLLANLKEIEEPFESTQIGSSAMAYKRNPMRSERVCSLSRHLSSLFLDAAGTS
SIQWFERTLDDSAIRRVSLPSAFLTADIVLSTLLNIVSGLVVYPKVIERRINSELPFMATENIIMAIVQKGGDRQECHEK
IRVLSHQAAAVVKQEGGDNDLIQRIKADEYFKPIWNDLDELLDPSTFVGRAPQQAEKFVKVTVANALKGLEHHINKKEEA
GLKV

GO term prediction

Biological Process

GO:0009152 purine ribonucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features