Protein

MIA_04520_1

Length
459 amino acids

Browser: contig06:235297-236677-

Protein function

EGGNOG:0PH7QBNA5Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
SGD closest match:S000004221BNA5Kynureninase
CGD closest match:CAL0000197943BNA5Kynureninase

Protein alignments

%idAln lengthE-value
A0A0J9X9I9_GEOCN62.527%4670.0Kynureninase OS=Geotrichum candidum GN=BNA5 PE=3 SV=1
MCA_03748_162.313%4670.0MCA_03748_1
A0A167EH98_9ASCO61.454%4540.0Kynureninase OS=Sugiyamaella lignohabitans GN=BNA5 PE=3 SV=1
A0A1E3PS07_9ASCO57.753%4450.0Kynureninase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=BNA5 PE=3 SV=1
A0A060T340_BLAAD57.143%4480.0Kynureninase OS=Blastobotrys adeninivorans GN=BNA5 PE=3 SV=1
UniRef50_A0A060T34057.143%4488.24e-179Kynureninase n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T340_BLAAD
A0A1E4TKV4_9ASCO55.581%4392.97e-164Kynureninase OS=Tortispora caseinolytica NRRL Y-17796 GN=BNA5 PE=3 SV=1
KYNU_YEAST52.473%4651.33e-161Kynureninase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BNA5 PE=1 SV=1
KYNU_CANAL49.677%4657.73e-157Kynureninase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BNA5 PE=3 SV=1
KYNU_YARLI55.366%4104.43e-155Kynureninase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BNA5 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5111
Predicted cleavage: 68

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 459

Detailed signature matches

  1. Family IPR010111
    Kynureninase
    1. TIGR01814
    2. MF_01970 (Kynureninase)
    3. PIRSF038800 (KYNU)
  2. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR000192
    Aminotransferase class V domain
    1. PF00266 (Aminotran_5)
  5. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)

Protein sequence

>MIA_04520_1
MAASAQLTLQAARALDSQYPSFAHLFAIPTLASLGSSKPVSKTQDLSAPSIYFCGNSLGLMPKATRAAVDAELNVWAARG
VVAHFRRDDPTGDGLEPWVSIDKPLAPLLAEVLGADGEDEVAAMNTLTGNLHTLLAAFYKPTQTRYKILFEDKAFPSDFY
AFQGQARMHGLDPEAALVPIKPREGEYTLRTEDILAAIDEHKESLAAVVFSGIQFYTGQYFDIKTITSHAHAASPEIVVG
WDLAHAAGNVDVRLHDWDVDFACFCSYKYLNAGPGGIGGIFVHRKHAQDKRARQAGWWGNNESTRFAMLPEFDAIPGAQG
FRMSNPSVLNTVCLYESLKIFKQAGSIKALRERSISMTTFLYRLLAESKFYVPVAQFDEEKKPSFTIITPEDPAQRGAQL
SLLFSRDTMEPVFEQLDARGIIGDERRPSVIRLAPNHLYNTHEEVYQVVEALNEIMTGL

GO term prediction

Biological Process

GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding
GO:0030429 kynureninase activity

Cellular Component

GO:0005737 cytoplasm