Protein

MCA_03748_1

Length
465 amino acids

Gene name: BNA5

Description: Kynureninase

Browser: contigC:965332-966730-

RNA-seq: read pairs 2090, FPKM 55.4, percentile rank 67.6% (100% = highest expression)

Protein function

Annotation:BNA5Kynureninase
KEGG:K01556KYNU kynureninase [EC:3.7.1.3]
EGGNOG:0PH7QBNA5Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
SGD closest match:S000004221BNA5Kynureninase
CGD closest match:CAL0000197943BNA5Kynureninase

Protein alignments

%idAln lengthE-value
MIA_04520_162.31%4670.0MIA_04520_1
A0A0J9X9I9_GEOCN60.17%4720.0Kynureninase OS=Geotrichum candidum GN=BNA5 PE=3 SV=1
A0A167EH98_9ASCO59.01%4660.0Kynureninase OS=Sugiyamaella lignohabitans GN=BNA5 PE=3 SV=1
A0A1E3PS07_9ASCO59.60%4530.0Kynureninase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=BNA5 PE=3 SV=1
A0A060T340_BLAAD54.33%4629e-176Kynureninase OS=Blastobotrys adeninivorans GN=BNA5 PE=3 SV=1
UniRef50_A0A060T34054.33%4622e-172Kynureninase n=4 Tax=Saccharomycetales TaxID=4892 RepID=A0A060T340_BLAAD
A0A1E4TKV4_9ASCO56.18%4456e-169Kynureninase OS=Tortispora caseinolytica NRRL Y-17796 GN=BNA5 PE=3 SV=1
KYNU_CANAL53.00%4662e-162Kynureninase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=BNA5 PE=3 SV=1
KYNU_YARLI53.69%4472e-161Kynureninase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=BNA5 PE=3 SV=1
KYNU_YEAST52.88%4691e-159Kynureninase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=BNA5 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0577

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 465

Detailed signature matches

  1. Family IPR010111
    Kynureninase
    1. TIGR01814
    2. MF_01970 (Kynureninase)
    3. PIRSF038800 (KYNU)
  2. Domain IPR015424
    Pyridoxal phosphate-dependent transferase
    1. SSF53383 (PLP-depen...)
  3. Domain IPR015421
    Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    1. G3DSA:3.40.64...
  4. Domain IPR000192
    Aminotransferase class V domain
    1. PF00266 (Aminotran_5)
  5. Domain IPR015422
    Pyridoxal phosphate-dependent transferase, subdomain 2
    1. G3DSA:3.90.11...

Protein sequence

>MCA_03748_1
MVSTSSIQTAAKLDEKYKHYRDEFSIPTVRSLGLEASDSELDKPCIYLCGNSLGLMPKSTKEAVNNELKVWADRGVVGHF
RRDDYDNLEPWVSIDKPVVPLLAPILGALESEVALMNTLTGNLHTLMASFYKPGIKTSRVKILFEDHAFPSDIYAFQSQA
ELHGLDFSEVLVPMKPRSGEFTLRTEDILTEIEKLGDQLALVIFSGIQYYTGQYFEIEKITAKGHEVGAVVGWDLAHAAG
NVDVKLHDWKVDFAVFCSYKYLNSGPGGIGGIFVHSDHSPKDRFRLAGWWGNNEETRFQMLDKFDPINGALGYRLSNPSV
LNVVCVKASLEIFEKAGGIIALRERSKSLTNYLYQLLISSPFYIPPSKALTSGSLETPKFTIITPENPDERGAQLSLLFI
DGSKTTTDTNYNLMEYVFGQLEKAGIIGDERRPNVIRLAPNPLYNTHQEVFKTVEVLNNIFDDLC

GO term prediction

Biological Process

GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0030170 pyridoxal phosphate binding
GO:0030429 kynureninase activity

Cellular Component

GO:0005737 cytoplasm