Protein

MIA_04512_1

Length
336 amino acids

Browser: contig06:222798-223897+

Protein function

EGGNOG:0PNMGPGUG_01793Meiotic recombination protein spo11
SGD closest match:S000001014SPO11Meiosis-specific protein SPO11
CGD closest match:CAL0000174721SPO11Spo11p

Protein alignments

%idAln lengthE-value
MCA_00801_147.959%1962.45e-49MCA_00801_1
A0A0J9XIL5_GEOCN38.023%2633.47e-49Similar to Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination OS=Geotrichum candidum GN=BN980_GECA19s01220g PE=4 SV=1
UniRef50_A0A0J9XIL538.023%2637.09e-46Similar to Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIL5_GEOCN
A0A060T4E7_BLAAD35.662%2726.64e-41ARAD1C03784p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C03784g PE=4 SV=1
A0A1E3PKV6_9ASCO27.193%3423.72e-24DNA topoisomerase IV, alpha subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_42051 PE=4 SV=1
Q6C1H0_YARLI31.944%2881.44e-22YALI0F16335p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F16335g PE=4 SV=1
SPO11_YEAST31.970%2691.13e-21Meiosis-specific protein SPO11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPO11 PE=1 SV=1
A0A1E4TCL3_9ASCO24.000%2754.99e-14Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_139734 PE=4 SV=1
A0A1D8PID6_CANAL27.068%2662.97e-11Spo11p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPO11 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1273
Predicted cleavage: 98

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 336

Detailed signature matches

  1. Family IPR002815
    Spo11/DNA topoisomerase VI subunit A
    1. PR01550 (TOP6AFAMILY)
    2. SSF56726 (DNA topoi...)
  2. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. G3DSA:1.10.10.10
  3. Domain IPR013049
    Spo11/DNA topoisomerase VI, subunit A, N-terminal
    1. PF04406 (TP6A_N)
  4. Domain IPR034136
    Topoisomerase 6 subunit A/Spo11, TOPRIM domain
    1. cd00223 (TOPRIM_Top...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.13...

Residue annotation

  1. metal binding site...
  2. active site cd00223
  3. interdomain intera...

Protein sequence

>MIA_04512_1
MTKTTPPGPPPLLCQIESLLNSIALQAKQGLQLTLTLPGPPSPRTLRFPPSSPSSTPPPLVVYVYILHQMALLIRSNSIT
TKRDLYYRNIPLFGSQKTVDRAVDAIAKSLRVQRIDLGVVAAPKSCVYIPQGSSVTLFSSSGSLRDLVGDSLIPVDLIPA
YIRINGSFSSVLIVEKEAVYRQLCSSSFSSASLASSPPLIVTGKGFPDLTCRVFLANLSASHPSLPIYALVDSDPHGISI
FLTYKFGNKTSQAPPIPKIRYLGVSLSDYRHEYPNKPSSAPAAHLINLTHRDVALAMSLIASRNWASDPQLKPVLRELQM
GLFLFKKAEMNNAATM

GO term prediction

Biological Process

GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process

Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome