Protein

MCA_00801_1

Length
455 amino acids

Gene name: SPO11

Description: Meiosis-specific protein SPO11

Browser: contigA:2500138-2501614+

RNA-seq: read pairs 261, FPKM 7.1, percentile rank 20.7% (100% = highest expression)

Protein function

Annotation:SPO11Meiosis-specific protein SPO11
KEGG:K10878SPO11 meiotic recombination protein SPO11
EGGNOG:0PNMGPGUG_01793Meiotic recombination protein spo11
SGD closest match:S000001014SPO11Meiosis-specific protein SPO11
CGD closest match:CAL0000174721SPO11Spo11p

Protein alignments

%idAln lengthE-value
MIA_04512_148.70%1936e-51MIA_04512_1
A0A0J9XIL5_GEOCN42.77%1594e-38Similar to Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination OS=Geotrichum candidum GN=BN980_GECA19s01220g PE=4 SV=1
UniRef50_A0A0J9XIL542.77%1598e-35Similar to Saccharomyces cerevisiae YHL022C SPO11 Meiosis-specific protein that initiates meiotic recombination n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIL5_GEOCN
A0A060T4E7_BLAAD38.12%2023e-38ARAD1C03784p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C03784g PE=4 SV=1
Q6C1H0_YARLI37.82%1933e-30YALI0F16335p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F16335g PE=4 SV=1
A0A1E3PKV6_9ASCO31.76%2553e-29DNA topoisomerase IV, alpha subunit OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_42051 PE=4 SV=1
A0A1E4TCL3_9ASCO30.10%2067e-19Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_139734 PE=4 SV=1
SPO11_YEAST30.13%2292e-15Meiosis-specific protein SPO11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPO11 PE=1 SV=1
A0A1D8PID6_CANAL28.35%1941e-09Spo11p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPO11 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0195

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 455

Detailed signature matches

  1. Family IPR002815
    Spo11/DNA topoisomerase VI subunit A
    1. PR01550 (TOP6AFAMILY)
    2. SSF56726 (DNA topoi...)
  2. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. G3DSA:1.10.10.10
  3. Domain IPR013049
    Spo11/DNA topoisomerase VI, subunit A, N-terminal
    1. PF04406 (TP6A_N)
  4. Domain IPR034136
    Topoisomerase 6 subunit A/Spo11, TOPRIM domain
    1. cd00223 (TOPRIM_Top...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.13...

Residue annotation

  1. metal binding site...
  2. active site cd00223
  3. interdomain intera...

Protein sequence

>MCA_00801_1
MVHHHTTLSHHHDAISSSSSTDLLSHLDILVSNIKSQLYSNVVPTTSSSYSPLILSLVTSKNTTSDNIKSTKNSLYLSFP
SNHSSHDSRSFAIYLQLLCYIRNLLRTNLIATKRDLYYRNVTLFQSQSVVDRAIDTISRALNVDRLQLNVVASPKSCIYG
SVTIIPNHSKEIIQLSNNSLIPVDISISYIRIPPDITTILVIEKEAVYRQLCGQLPNSILLVTAKGFPDLSCRRFLHSIG
KFYPDVAIKALIDSDPWGIHIFLSFKFGINKSSSNRKKRNTGFFSSRSRTRKCNNNNIKRIKLEESLQRHSNDSNSGYDF
KNGDDNNETLVEFQSNNDNNNTFPVPNLQFLGVSLLDYNIVSQMNKQNNKDTTSTTWLKMSQKDIQMAFNLLQQPWAYSC
SKEFFDIKRELQLSLFLNKKAEMNTVFSSSTDKTNNNDNQDNKCIVDYVKSKLNI

GO term prediction

Biological Process

GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process

Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0005524 ATP binding

Cellular Component

GO:0005694 chromosome