Protein
MIA_04483_1
Length
606 amino acids
Browser: contig06:153257-155078-
Protein function
EGGNOG: | 0PGJG | 2-isopropylmalate synthase | |
---|---|---|---|
SGD closest match: | S000005048 | LEU4 | 2-isopropylmalate synthase |
CGD closest match: | CAL0000201867 | LEU42 | Leu42p |
Protein alignments
%id | Aln length | E-value | ||
---|---|---|---|---|
MCA_01672_1 | 86.589% | 604 | 0.0 | MCA_01672_1 |
A0A0J9YHA9_GEOCN | 74.915% | 590 | 0.0 | Similar to Saccharomyces cerevisiae YNL104C LEU4 Alpha-isopropylmalate synthase (2-isopropylmalate synthase) OS=Geotrichum candidum GN=BN980_GECA01s01660g PE=3 SV=1 |
Q6CFF6_YARLI | 69.336% | 587 | 0.0 | YALI0B07447p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B07447g PE=3 SV=1 |
A0A167F8Y7_9ASCO | 70.578% | 588 | 0.0 | 2-isopropylmalate synthase LEU4 OS=Sugiyamaella lignohabitans GN=LEU4 PE=3 SV=1 |
A0A1E3PRT7_9ASCO | 69.844% | 577 | 0.0 | Alpha-isopropylmalate synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_49972 PE=3 SV=1 |
A0A060T5N2_BLAAD | 70.377% | 584 | 0.0 | ARAD1B08338p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B08338g PE=3 SV=1 |
A0A1D8PIF8_CANAL | 64.189% | 592 | 0.0 | Leu42p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=LEU42 PE=3 SV=1 |
A0A1E4TKN6_9ASCO | 62.222% | 585 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_85004 PE=3 SV=1 |
LEU1_YEAST | 61.368% | 585 | 0.0 | 2-isopropylmalate synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU4 PE=1 SV=1 |
UniRef50_P06208 | 61.368% | 585 | 0.0 | 2-isopropylmalate synthase n=256 Tax=Opisthokonta TaxID=33154 RepID=LEU1_YEAST |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0206
Predicted cleavage: 20
Protein family membership
- 2-isopropylmalate synthase (IPR005668)
Domains and repeats
-
Domain
1
100
200
300
400
500
606
Detailed signature matches
Residue annotation
-
catalytic residues...
-
active site cd07942
-
metal binding site...
Protein sequence
>MIA_04483_1 MLQCPCSKYRPFPPVKLPERTWPDRTLTKPPRWLSTDLRDGNQSLPDPMTVDEKKEYFQKLVEIGFKEIEVAFPSASQPD FDFTRFAVQTAPEDVAVQVLAPCREELIRRTVESLQGAHRAIVHIYLATSELFRDVVFGMQEDESIALAVKCAALVRQLT KDAPEPSIAPSGKPTVWSFEFSPETFSDSDMGFAVRICEAVKNAWGPSEENPIIFNLPATVEMTTPNVYADQVEYFSTHI SEREKVCISLHPHNDRGCAVAAAELAQMGGGQRVEGCLFGNGERTGNVDLVTLALNLYTQGVYPNLDFSDMMSVIDVVER CNKIPVAPRAPYGGSLVVCAFSGSHQDAIKKGFARRQKQTKGDPQTEENTHWRIPYLPLDPKDIGRTYEAVIRVNSQSGK GGAAWIILRNLELDLPRGLQVAFSKVVQDAAEVKGRELKTKELVDLFEKQYFLEESQVGHVYSLDSEEDFNIVSTGKDKR QFQGFLSINGTKHKITGNGNGPISSFTDAVNTLVEDSFGPLEVLTYHEHSIGAGSNTKAATYIEMSAVNPKNKAHKIKQW GVGIHEDVSQASIQAILSIVNSIVRDFPEAAPKANGATKVNGTNGH
GO term prediction
Biological Process
GO:0009098 leucine biosynthetic process
GO:0019752 carboxylic acid metabolic process
Molecular Function
GO:0003824 catalytic activity
GO:0003852 2-isopropylmalate synthase activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
Cellular Component
None predicted.