Protein

MIA_04479_1

Length
259 amino acids

Browser: contig06:143573-144353-

Protein function

EGGNOG:0PG6QADK1Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways (By similarity)
SGD closest match:S000002634ADK1Adenylate kinase
CGD closest match:CAL0000198757ADK1Adenylate kinase

Protein alignments

%idAln lengthE-value
MCA_05773_184.556%2593.31e-165MCA_05773_1
A0A0J9X5J2_GEOCN82.101%2571.48e-160Adenylate kinase OS=Geotrichum candidum GN=ADK1 PE=3 SV=1
A0A1E3PQN7_9ASCO78.715%2496.98e-151Adenylate kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=ADK1 PE=3 SV=1
KAD2_CANAL76.892%2511.55e-145Adenylate kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADK1 PE=3 SV=2
KAD2_YARLI76.078%2551.38e-143Adenylate kinase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ADK1 PE=3 SV=2
A0A167CDQ7_9ASCO72.112%2512.25e-142Adenylate kinase OS=Sugiyamaella lignohabitans GN=ADK1 PE=3 SV=1
A0A060SYI1_BLAAD73.413%2524.78e-140Adenylate kinase OS=Blastobotrys adeninivorans GN=ADK1 PE=3 SV=1
UniRef50_A2QPN973.494%2492.79e-133Adenylate kinase n=202 Tax=Eukaryota TaxID=2759 RepID=KAD2_ASPNC
KAD2_YEAST80.189%2129.98e-132Adenylate kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADK1 PE=1 SV=2
A0A1E4TJR4_9ASCO66.142%2543.27e-127Adenylate kinase OS=Tortispora caseinolytica NRRL Y-17796 GN=ADK1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1415

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 259

Detailed signature matches

  1. Family IPR000850
    Adenylate kinase/UMP-CMP kinase
    1. PR00094 (ADENYLTKNASE)
    2. MF_00235 (Adenylate...)
    3. cd01428 (ADK)
  2. Family IPR006259
    Adenylate kinase subfamily
    1. TIGR01351
  3. Family IPR028587
    Adenylate kinase 2
    1. MF_03168 (Adenylate...)
  4. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  5. Domain IPR007862
    Adenylate kinase, active site lid domain
    1. PF05191 (ADK_lid)
  6. SITE IPR033690
    Adenylate kinase, conserved site
    1. PS00113 (ADENYLATE_...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.40.50...
  3. PF00406 (ADK)

Residue annotation

  1. AMP-binding site c...
  2. ATP-AMP (Ap5A)-bin...

Protein sequence

>MIA_04479_1
MSAPEDLKKIIADLEAKVVSLESQLKEKADALFHPAAQVPKSIRMVLIGPPGAGKGTQAPNLKEKFCACHLATGDMLRSQ
VAQKTALGLEAKKIMDQGGLVSDEIMVNMIKNELENNSECKNGFILDGFPRTIPQAERLDTMLEERKTPLQKAVELQIED
DLLVARITGRLVHPASGRSYHRLFNPPKEDMKDDITGEPLVQRSDDNADALKKRLVTYHAQTAPVVSYYKKTGIWAGVDA
AQDPKVVWQSILKCFEDAK

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process
GO:0006172 ADP biosynthetic process

Molecular Function

GO:0004017 adenylate kinase activity
GO:0005524 ATP binding
GO:0016776 phosphotransferase activity, phosphate group as acceptor
GO:0019205 nucleobase-containing compound kinase activity

Cellular Component

None predicted.