Protein

MIA_04323_1

Length
433 amino acids

Browser: contig05:1414524-1415907-

Protein function

EGGNOG:0PHPUPGUG_00804Subtilase family
SGD closest match:S000000641RRT12Subtilase-type proteinase RRT12
CGD closest match:CAL0000199679CAALFM_CR00660WAUncharacterized protein

Protein alignments

%idAln lengthE-value
MCA_01877_159.233%4174.22e-148MCA_01877_1
A0A0J9X633_GEOCN49.746%3946.56e-115Similar to Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease OS=Geotrichum candidum GN=BN980_GECA03s05532g PE=3 SV=1
UniRef50_A0A0J9X63349.746%3941.34e-111Similar to Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X633_GEOCN
A0A060T6Y8_BLAAD50.372%4038.21e-114ARAD1B15928p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15928g PE=3 SV=1
Q6C0I2_YARLI45.854%4106.34e-86YALI0F24453p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F24453g PE=3 SV=1
A0A1D8PRS3_CANAL40.821%4141.37e-84Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR00660WA PE=3 SV=1
A0A1E4THQ1_9ASCO40.204%3931.12e-70Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_121669 PE=3 SV=1
RRT12_YEAST38.875%3915.24e-63Subtilase-type proteinase RRT12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRT12 PE=1 SV=1
A0A170QYI2_9ASCO34.204%3831.06e-41Proteinase B OS=Sugiyamaella lignohabitans GN=PRB1 PE=3 SV=1
A0A1E3PQF7_9ASCO35.036%2743.82e-43Subtilisin-like protein (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82078 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3363
Predicted cleavage: 47

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 350 400 433

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR010259
    Peptidase S8 propeptide/proteinase inhibitor I9
    1. G3DSA:3.30.70.80
  3. Domain IPR000209
    Peptidase S8/S53 domain
    1. G3DSA:3.40.50...
    2. PF00082 (Peptidase_S8)
    3. SSF52743 (Subtilisi...)
  4. Domain IPR034193
    Proteinase K-like catalytic domain
    1. cd04077 (Peptidases...)
  5. SITE IPR023827
    Peptidase S8, subtilisin, Asp-active site
    1. PS00136 (SUBTILASE_ASP)
  6. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. NON_CYTOPLASM... (N...)
  2. SIGNAL_PEPTIDE (Sig...)
  3. SIGNAL_PEPTID... (S...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SignalP-noTM
  7. mobidb-lite (disord...)

Residue annotation

  1. calcium binding si...
  2. active site cd04077
  3. catalytic triad cd...
  4. calcium binding si...

Protein sequence

>MIA_04323_1
MKLFRAYLLNVCVCLLATVEANIIVKLSSSSTVGTFFHRYPQIMRHVGQVYSFGDFVGFSGNFNLNVIRALQHNPFVKSI
VPDTQVMTTEEFELRGAADGEEEDVVAMEVQRNAPRHLARIQQRQRLQVTDKFTYEYFGTPKELVDVYVVDTGVRKDHSQ
LEGRVTFQKDFTGEGIGDSNGHGKYLRYISTFLTLLGTHVAGLVGSRGYGVYKQARFIDLKVLQGSGVGNLSTVIAGIDY
AVNHRIGTRRKAVANLSVGATYNVVLNDAVNAAVESGLLVVVAAGNANSAACNYSPASASRVVTVGAVDDRYDAVASFSN
WGRCVDIFASGVYVVSLSPHQESPTMALSGTSMSAPIVAGIMAQFMAQGDGPEEAIERLLSRGTHGAIPRSSLFLRPRTI
NLLAYNKEPEEDVGGGGSEEDDGEDDGEDEDYE

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.