Protein

MCA_01877_1

Length
437 amino acids

Gene name: RRT12A

Description: subtilisin-related peptidase

Browser: contigA:5752997-5754482+

RNA-seq: read pairs 791, FPKM 22.3, percentile rank 44.3% (100% = highest expression)

Protein function

Annotation:RRT12Asubtilisin-related peptidase
KEGG:K14644OSW3 subtilase-type proteinase RRT12 [EC:3.4.21.-]
EGGNOG:0PHPUPGUG_00804Subtilase family
SGD closest match:S000000641RRT12Subtilase-type proteinase RRT12
CGD closest match:CAL0000199679CAALFM_CR00660WAUncharacterized protein

Protein alignments

%idAln lengthE-value
MIA_04323_159.38%4169e-145MIA_04323_1
A0A0J9X633_GEOCN59.32%2951e-117Similar to Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease OS=Geotrichum candidum GN=BN980_GECA03s05532g PE=3 SV=1
UniRef50_A0A0J9X63359.32%2953e-114Similar to Saccharomyces cerevisiae YCR045C RRT12 Probable subtilisin-family protease n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X633_GEOCN
A0A060T6Y8_BLAAD48.44%4171e-116ARAD1B15928p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B15928g PE=3 SV=1
Q6C0I2_YARLI45.86%4234e-96YALI0F24453p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F24453g PE=3 SV=1
A0A1D8PRS3_CANAL49.31%2881e-88Uncharacterized protein OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CAALFM_CR00660WA PE=3 SV=1
RRT12_YEAST43.61%3602e-84Subtilase-type proteinase RRT12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRT12 PE=1 SV=1
A0A1E4THQ1_9ASCO48.99%2985e-82Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_121669 PE=3 SV=1
A0A1E3PKP3_9ASCO44.53%2563e-53Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_82571 PE=3 SV=1
A0A170QYI2_9ASCO43.73%2632e-52Proteinase B OS=Sugiyamaella lignohabitans GN=PRB1 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0057

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 350 400 437

Detailed signature matches

  1. Family IPR015500
    Peptidase S8, subtilisin-related
    1. PR00723 (SUBTILISIN)
  2. Domain IPR010259
    Peptidase S8 propeptide/proteinase inhibitor I9
    1. G3DSA:3.30.70.80
  3. Domain IPR009020
    Protease propeptides/proteinase inhibitor I9
    1. SSF54897 (Protease ...)
  4. Domain IPR000209
    Peptidase S8/S53 domain
    1. G3DSA:3.40.50...
    2. PF00082 (Peptidase_S8)
    3. SSF52743 (Subtilisi...)
  5. Domain IPR034193
    Proteinase K-like catalytic domain
    1. cd04077 (Peptidases...)
  6. SITE IPR023827
    Peptidase S8, subtilisin, Asp-active site
    1. PS00136 (SUBTILASE_ASP)
  7. SITE IPR022398
    Peptidase S8, subtilisin, His-active site
    1. PS00137 (SUBTILASE_HIS)
  8. SITE IPR023828
    Peptidase S8, subtilisin, Ser-active site
    1. PS00138 (SUBTILASE_SER)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SignalP-noTM

Residue annotation

  1. calcium binding si...
  2. catalytic triad cd...
  3. active site cd04077
  4. calcium binding si...

Protein sequence

>MCA_01877_1
MLFILLVSLQLSVVDANIIVKLKDSSTIGEFFRWNPTLYRHVGQVYSFGSFVGFSGNFNLNNIRLLQNSPWVKSIVPDIQ
VKTTEYHVHEEYEEENSNIEKNENDKSTELQDQKNMVTQQNAPNVLATQYGAPRHLARIQQRQKLRLDGESFLKYQYNVD
PKDKVNVYVIDTGVYKYHPEFENRVILQKDFTGEGEGDDNGHGTHVAGLVGSKNYGVFKQANIIDVKVLHNAGTGNLSSV
IAGIDFAANHRHKTGKKSVANLSVGALYSSMLNEAVNAAVDSGLQLVVAAGNSNTPACTTSPASASKAITVGAVDDRHDN
IASFSNWGKCVDIFASGVYVVSLSKNNNGTMAISGTSMSTPIVTGIIAQFLAGGDSTEIAVERLFVAGTRGAIPRKSVFV
RPKTVNLMAFNNVRIEKRNSYVDESEYDDESDDSDSE

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

None predicted.