Protein

MIA_04295_1

Length
358 amino acids

Browser: contig05:1337065-1338142-

Protein function

EGGNOG:0PISCFG10211.1homoserine kinase
SGD closest match:S000001067THR1Homoserine kinase
CGD closest match:CAL0000196189THR1Homoserine kinase

Protein alignments

%idAln lengthE-value
MCA_06087_181.844%3580.0MCA_06087_1
A0A0J9X8T6_GEOCN75.921%3530.0Similar to Saccharomyces cerevisiae YHR025W THR1 Homoserine kinase, conserved protein required for threonine biosynthesis OS=Geotrichum candidum GN=BN980_GECA04s05939g PE=3 SV=1
A0A167F610_9ASCO74.230%3570.0Homoserine kinase OS=Sugiyamaella lignohabitans GN=THR1 PE=3 SV=1
Q6C1T8_YARLI74.022%3580.0YALI0F13453p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F13453g PE=3 SV=1
A0A060T8N9_BLAAD70.056%3544.05e-180ARAD1C38368p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C38368g PE=3 SV=1
KHSE_YEAST69.916%3595.40e-175Homoserine kinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=THR1 PE=1 SV=4
UniRef50_P1742369.916%3591.29e-171Homoserine kinase n=349 Tax=Fungi TaxID=4751 RepID=KHSE_YEAST
A0A1E3PCM0_9ASCO64.463%3632.35e-166Homoserine kinase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_84377 PE=3 SV=1
A0A1E4TLW7_9ASCO66.011%3566.73e-163Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_92624 PE=3 SV=1
KHSE_CANAL54.902%3577.11e-135Homoserine kinase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=THR1 PE=3 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.2475
Predicted cleavage: 13

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 300 358

Detailed signature matches

  1. Family IPR000870
    Homoserine kinase
    1. TIGR00191
    2. PIRSF000676 (Homose...)
    3. MF_00384 (Homoser_k...)
  2. Domain IPR020568
    Ribosomal protein S5 domain 2-type fold
    1. SSF54211 (Ribosomal...)
  3. Domain IPR014721
    Ribosomal protein S5 domain 2-type fold, subgroup
    1. G3DSA:3.30.23...
  4. Domain IPR006204
    GHMP kinase N-terminal domain
    1. PF00288 (GHMP_kinas...)
  5. Domain IPR013750
    GHMP kinase, C-terminal domain
    1. PF08544 (GHMP_kinas...)
    2. SSF55060 (GHMP Kina...)
    3. G3DSA:3.30.70...
  6. SITE IPR006203
    GHMP kinase, ATP-binding, conserved site
    1. PS00627 (GHMP_KINAS...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. PR00958 (HOMSERKINASE)

Protein sequence

>MIA_04295_1
MPRAFKISVPASSANIGPGFDVLGLALSLFLELTVTLDPSKPLSEFEAAIFDENCRISYEGEGAEEVPLLASHNLITRVA
LYVLKVNGLQTFPIGTHVHVNNPIPLGRGLGSSGAAVVAGVMLANEIGNFEFSKQRMLDYCLMIERHPDNITAAMIGGFV
GSYLRDLSEAELCRVEIPLAEVLPEPAGGINTGLVPPEPPLNIGHHIKYDWCPQVKAVCIVPAFEVSTAKSREVLPTAYT
KKDLVFNLQRLAVLTTALSRSPPNPDLIFPAMQDRVHQPYRKVLIPGLTEILQSMTPKTHPGLLGICLSGAGPTILALAT
HNFDAIAEEIVSQFEKEKIKCQWKLLEPAYDGAQVQEL

GO term prediction

Biological Process

GO:0006566 threonine metabolic process

Molecular Function

GO:0004413 homoserine kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.