Protein

MIA_04279_1

Length
351 amino acids

Browser: contig05:1294960-1296016-

Protein function

EGGNOG:0QE7USAM4homocysteine S-methyltransferase
SGD closest match:S000006194SAM4Homocysteine S-methyltransferase 2
CGD closest match:CAL0000183325SAM4S-adenosylmethionine-homocysteine S-methyltransferase

Protein alignments

%idAln lengthE-value
MCA_06354_145.559%3491.10e-87MCA_06354_1
UniRef50_A0A1H3KIF438.253%3328.49e-66Homocysteine S-methyltransferase n=4 Tax=Lachnospiraceae TaxID=186803 RepID=A0A1H3KIF4_9FIRM
A0A1E3PMX2_9ASCO40.173%3464.98e-67Homocysteine S-methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_42154 PE=4 SV=1
A0A0J9X346_GEOCN33.738%4121.67e-52Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s08799g PE=4 SV=1
Q6C0D6_YARLI35.450%3785.94e-51YALI0F25641p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25641g PE=4 SV=1
A0A1D8PEB0_CANAL30.655%3361.90e-40S-adenosylmethionine-homocysteine S-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SAM4 PE=4 SV=1
SAM4_YEAST28.852%3573.08e-37Homocysteine S-methyltransferase 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAM4 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0373

Protein family membership

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 351

Detailed signature matches

  1. Family IPR017226
    Betaine-homocysteine S-methyltransferase, BHMT
    1. PIRSF037505 (BHMT)
  2. Domain IPR003726
    Homocysteine-binding domain
    1. PF02574 (S-methyl_t...)
    2. PS50970 (HCY)
    3. SSF82282 (Homocyste...)
    4. G3DSA:3.20.20...

Protein sequence

>MIA_04279_1
MASILPDNSSVLVLDGGLGSELENRGVPVGSSHLWSAELLISNPAALRDLHAAYIAAGADVVTTASYQASFPGIIRYFEE
KQGPGDYAELAEKYIADSVLIAQEARDAFWEKNNASSDRIKPLVAASIGPYGAYLAAGQEYTGDYGFTNDEEAQKTLRDF
HKPRLDALLSANPDIIALETIPSLLETEVLLDLLATTKTSNPVPVWLAFSIDPAAATTLADGSPLADAVNLIAKYADSPG
LHVFAIGINCLPPHRAQKALHTLSQELSRAKLSLPLVVYPNSGEIYDGTTKEWAPNPEGVSKAADETHLCFHQFLPDWYA
SGARLVGGCCRTGPSDISELRGQLQALAQQA

GO term prediction

Biological Process

GO:0009086 methionine biosynthetic process

Molecular Function

GO:0008270 zinc ion binding
GO:0047150 betaine-homocysteine S-methyltransferase activity

Cellular Component

GO:0005737 cytoplasm