Protein
MCA_06354_1
Length
340 amino acids
Gene name: SAM4
Description: S-adenosylmethionine-homocysteine S-methyltransferase
Browser: contigD:3967600-3968623-
RNA-seq: read pairs 715, FPKM 25.9, percentile rank 48.6% (100% = highest expression)
Protein function
| Annotation: | SAM4 | S-adenosylmethionine-homocysteine S-methyltransferase | |
|---|---|---|---|
| KEGG: | K00547 | mmuM | homocysteine S-methyltransferase [EC:2.1.1.10] |
| EGGNOG: | 0QE7U | SAM4 | homocysteine S-methyltransferase |
| SGD closest match: | S000003985 | MHT1 | Homocysteine S-methyltransferase 1 |
| CGD closest match: | CAL0000183325 | SAM4 | S-adenosylmethionine-homocysteine S-methyltransferase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04279_1 | 44.57% | 359 | 2e-93 | MIA_04279_1 |
| UniRef50_E3E918 | 42.51% | 327 | 1e-71 | Homocysteine methyltransferase n=188 Tax=Bacteria TaxID=2 RepID=E3E918_PAEPS |
| A0A1E3PMX2_9ASCO | 36.57% | 350 | 2e-58 | Homocysteine S-methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_42154 PE=4 SV=1 |
| Q6C0D6_YARLI | 31.47% | 375 | 2e-48 | YALI0F25641p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F25641g PE=4 SV=1 |
| A0A0J9X346_GEOCN | 32.20% | 410 | 1e-47 | Uncharacterized protein OS=Geotrichum candidum GN=BN980_GECA01s08799g PE=4 SV=1 |
| MHT1_YEAST | 32.47% | 348 | 1e-32 | Homocysteine S-methyltransferase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MHT1 PE=1 SV=1 |
| A0A1D8PEB0_CANAL | 30.51% | 331 | 3e-31 | S-adenosylmethionine-homocysteine S-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SAM4 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0296
Protein family membership
- Betaine-homocysteine S-methyltransferase, BHMT (IPR017226)
Domains and repeats
-
Domain
1
50
100
150
200
250
300
340
Detailed signature matches
-
-
PIRSF037505 (BHMT)
-
-
Protein sequence
>MCA_06354_1 MSENNSKDKIFILDGGLGSQLEDEGVGNSYLWSAELLLSNPDRLRQIHTLYYEAGADIVTTASYQASVEGIVRRCKETGR PDTEEQALKFIASSVDIAKQARDEFWDKYEGSLSESQIQRQKPFVAASVGPYGAFLAQGEEYTGNYGEKTTYQTLREFHG SRLRALVSATPDFIAFETMPNFLEIKVLRDIIDSIDNCAPFWISFSVGKTKDTIADGTTLGECLETLFSSSKAKSLCAAV GVNCLSPSSVSHYLTNIKAWLDKNWDGEAAQPQLVAYPNSGEIYDGVAKKWSGSTSASIMDYLDEWYNIGARYIGGCCRT TPKDIALIRAHFDLKTKKAI
GO term prediction
Biological Process
GO:0009086 methionine biosynthetic process
Molecular Function
GO:0008270 zinc ion binding
GO:0047150 betaine-homocysteine S-methyltransferase activity
Cellular Component
GO:0005737 cytoplasm