Protein

MIA_04277_1

Length
343 amino acids

Browser: contig05:1293050-1294082-

Protein function

EGGNOG:0PJT2FG01476.1NADPH-dependent methylglyoxal reductase GRE2
SGD closest match:S000003007YGL039WPutative uncharacterized oxidoreductase YGL039W
CGD closest match:CAL0000179051orf19.5611Methylglyoxal reductase (NADPH-dependent)

Protein alignments

%idAln lengthE-value
MCA_06352_161.22%3431e-146MCA_06352_1
A0A0J9XCC0_GEOCN58.46%3373e-138Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase OS=Geotrichum candidum GN=BN980_GECA07s05433g PE=4 SV=1
UniRef50_A0A0J9XB2257.27%3378e-127Similar to Saccharomyces cerevisiae YGL157W ARI1 NADPH-dependent aldehyde reductase n=2 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XB22_GEOCN
Q6C9S0_YARLI45.99%3378e-92YALI0D08844p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D08844g PE=4 SV=1
A0A1E3PSR4_9ASCO45.09%3462e-84Putative NADPH-dependent methylglyoxal reductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_45022 PE=4 SV=1
A0A060T4V0_BLAAD44.71%3404e-83ARAD1B02860p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B02860g PE=4 SV=1
A0A167C177_9ASCO43.60%3449e-83Carbonyl reductase (NADPH-dependent) OS=Sugiyamaella lignohabitans GN=AWJ20_3889 PE=4 SV=1
YGD9_YEAST42.36%3477e-80Putative uncharacterized oxidoreductase YGL039W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YGL039W PE=1 SV=1
Q5ABT9_CANAL41.67%3362e-75Methylglyoxal reductase (NADPH-dependent) OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=orf19.5611 PE=4 SV=1
A0A1E4T9D1_9ASCO39.54%3493e-63Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_4495 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.5922

Protein family membership

None predicted.

Domains and repeats

  1. Domain
1 50 100 150 200 250 300 343

Detailed signature matches

  1. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  2. Domain IPR001509
    NAD-dependent epimerase/dehydratase
    1. PF01370 (Epimerase)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.25.10
  3. NON_CYTOPLASM... (N...)
  4. SIGNAL_PEPTIDE (Sig...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. SIGNAL_PEPTID... (S...)
  8. cd05227 (AR_SDR_e)

Residue annotation

  1. NADP binding site ...
  2. putative substrate...
  3. active site cd05227

Protein sequence

>MIA_04277_1
MTKVLLTGASGFVAIHTLEALLTRGYTVKATVRSKEKGRYLLNKFPGKPLEIAIVEDIQAPSAFESALKDSAITAVIHTA
SPFFAAKSDPLKELLDPAVKGTKNVLKAIKTFAPQVSTVVVTSSYAAISNVSKRSDHSFVHTEATWADITWEQAISNLSF
SYRASKKFAEKALWDFVAEEKPNFSATTVNPPLVYGPVIQDVSIPEKLNTSNAILWKNVIESTPGDTSDSYANDAALWVD
VRDVALAHVLPLEKPELAGKRLFVTPGFCSTQSILDVLNNKLPALKGKIAIGRPGTGDKQLPELYQYDNHVTNELLGIKY
HTLEECMVDTFSTLVKLQPKSSL

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003824 catalytic activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.