Protein

MIA_04247_1

Length
757 amino acids

Browser: contig05:1184850-1187293+

Protein function

EGGNOG:0PFQYEXO1exonuclease
SGD closest match:S000005559EXO1Exodeoxyribonuclease 1
CGD closest match:CAL0000175291EXO1Rad2 family nuclease

Protein alignments

%idAln lengthE-value
MCA_03403_149.370%4762.06e-149MCA_03403_1
A0A1E3PIZ2_9ASCO53.293%3341.92e-131PIN domain-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51501 PE=4 SV=1
UniRef50_A0A1E3PIZ253.293%3345.22e-128PIN domain-like protein n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PIZ2_9ASCO
A0A0J9XAE3_GEOCN48.333%4202.39e-128Similar to Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap-endonuclease involved in recombination OS=Geotrichum candidum GN=BN980_GECA06s04971g PE=4 SV=1
A0A060SYI7_BLAAD46.084%3322.72e-104ARAD1C01540p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01540g PE=4 SV=1
Q6C5Y7_YARLI41.441%3331.33e-90YALI0E14014p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14014g PE=4 SV=1
A0A1E4TLK2_9ASCO42.814%3341.22e-89Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17583 PE=4 SV=1
EXO1_YEAST39.896%3868.80e-84Exodeoxyribonuclease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EXO1 PE=1 SV=2
A0A1D8PMZ2_CANAL37.941%3405.49e-76Rad2 family nuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=EXO1 PE=4 SV=1
A0A167FLR7_9ASCO63.025%1191.51e-44Exodeoxyribonuclease DIN7 OS=Sugiyamaella lignohabitans GN=DIN7 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1193
Predicted cleavage: 54

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
  4. Repeat
1 100 200 300 400 500 600 700 757

Detailed signature matches

  1. Family IPR006084
    XPG/Rad2 endonuclease
    1. PR00853 (XPGRADSUPER)
  2. Domain IPR006085
    XPG N-terminal
    1. SM00485 (xpgn3)
    2. PF00752 (XPG_N)
  3. Domain IPR029060
    PIN domain-like
    1. G3DSA:3.40.50...
    2. SSF88723 (PIN domai...)
  4. Domain IPR013026
    Tetratricopeptide repeat-containing domain
    1. PS50293 (TPR_REGION)
  5. Domain IPR006086
    XPG-I domain
    1. SM00484 (xpgineu)
    2. PF00867 (XPG_I)
  6. Domain IPR020045
    5'-3' exonuclease, C-terminal domain
    1. SSF47807 (5' to 3' ...)
  7. Repeat IPR019734
    Tetratricopeptide repeat
    1. PS50005 (TPR)
  8. SITE IPR008918
    Helix-hairpin-helix motif, class 2
    1. SM00279 (HhH_4)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.15...
  2. cd09857 (PIN_EXO1)
  3. mobidb-lite (disord...)

Residue annotation

  1. metal binding site...
  2. active site cd09857
  3. putative 5' ssDNA ...
  4. metal binding site...

Protein sequence

>MIA_04247_1
MGVQGLLGVLKSISVETNISQYRGQSIGIDGYAWLHRGAISCARDLATGKYTKRHLDFFIRRLRTLIINGVTPFVVFDGD
YLPTKGRIEKSRENSRSECLEQGIILLRRGQSQEAEKFFQKAVDITPEIVAQLIEILKRENIQYVVAPYEADAQLVYLEK
TGAISAIIAEDSDLLVFGASVLLTKMDDQGKCISVERRNFKNCKELVLTDLTDAQFRAMALFSGCDYSNGIPKIGLKKAH
FYIRKYTTAERALRCMRCDGFEIPTNFENEFEQGDITFQYQRVYSITQKKLVHLNDPPMKLSPEAEIYVGQLVDDEISQG
IASGHLNPFTKQPIQQSILHKTPTTVSLPHTNSLNASASNRISMPMSASNNTKITQFFTPSKKVSPNTTKRASSSYMPTT
SSRPAARNVNSEIVLPLKTPETAQKSLVRRRVDRFIGSDEKKSVRSTASSQATIADPISSTESGTTLGNNEERAESTIQH
QVVSKFFSSVSSRSKTVDDSLDEKSRDEKFVNNFISSVTSKATTLEDSFKFPSDSDSDDEFDIPSKPPARSALDTPMSST
AKNPNIWSRSSKIVFEKKEDNKITTLTVSQQERVMNLKKFAYSSSSQSSSSSTPAVIHRPNIGRANAQTAHSISSYETPQ
STKTKTFLVSDPRELIDPDSDSGSSDVETPKHMRVNENVNFTLKDTGNCPHLQSPTRGVPSKKVRVTATTSRALFTTAGP
VSRMSAGSNRESLPNSSFDSLSKISNKFAEFCYVPKK

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0005515 protein binding

Cellular Component

None predicted.