Protein

MCA_03403_1

Length
665 amino acids

Gene name: EXO1

Description: Exodeoxyribonuclease 1

Browser: contigB:4347580-4349578-

RNA-seq: read pairs 492, FPKM 9.1, percentile rank 24.5% (100% = highest expression)

Protein function

Annotation:EXO1Exodeoxyribonuclease 1
KEGG:K10746EXO1 exonuclease 1 [EC:3.1.-.-]
EGGNOG:0PFQYEXO1exonuclease
SGD closest match:S000005559EXO1Exodeoxyribonuclease 1
CGD closest match:CAL0000175291EXO1Rad2 family nuclease

Protein alignments

%idAln lengthE-value
MIA_04247_150.11%4633e-144MIA_04247_1
A0A1E3PIZ2_9ASCO49.26%3371e-117PIN domain-like protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51501 PE=4 SV=1
UniRef50_A0A1E3PIZ249.26%3373e-114PIN domain-like protein n=1 Tax=Nadsonia fulvescens var. elongata DSM 6958 TaxID=857566 RepID=A0A1E3PIZ2_9ASCO
A0A0J9XAE3_GEOCN53.18%3141e-111Similar to Saccharomyces cerevisiae YOR033C EXO1 5'-3' exonuclease and flap-endonuclease involved in recombination OS=Geotrichum candidum GN=BN980_GECA06s04971g PE=4 SV=1
A0A060SYI7_BLAAD44.93%3659e-104ARAD1C01540p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C01540g PE=4 SV=1
Q6C5Y7_YARLI42.77%3462e-90YALI0E14014p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_E14014g PE=4 SV=1
EXO1_YEAST39.00%4005e-82Exodeoxyribonuclease 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EXO1 PE=1 SV=2
A0A1D8PMZ2_CANAL39.59%3414e-77Rad2 family nuclease OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=EXO1 PE=4 SV=1
A0A1E4TLK2_9ASCO40.72%3341e-78Uncharacterized protein (Fragment) OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_17583 PE=4 SV=1
A0A167FLR7_9ASCO59.17%1202e-37Exodeoxyribonuclease DIN7 OS=Sugiyamaella lignohabitans GN=DIN7 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0684

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 100 200 300 400 500 600 665

Detailed signature matches

  1. Family IPR006084
    XPG/Rad2 endonuclease
    1. PR00853 (XPGRADSUPER)
  2. Domain IPR006085
    XPG N-terminal
    1. SM00485 (xpgn3)
    2. PF00752 (XPG_N)
  3. Domain IPR029060
    PIN domain-like
    1. G3DSA:3.40.50...
    2. SSF88723 (PIN domai...)
  4. Domain IPR006086
    XPG-I domain
    1. SM00484 (xpgineu)
    2. PF00867 (XPG_I)
  5. Domain IPR020045
    5'-3' exonuclease, C-terminal domain
    1. SSF47807 (5' to 3' ...)
  6. SITE IPR019974
    XPG conserved site
    1. PS00842 (XPG_2)
    2. PS00841 (XPG_1)
  7. SITE IPR008918
    Helix-hairpin-helix motif, class 2
    1. SM00279 (HhH_4)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:1.10.15...
  2. cd09857 (PIN_EXO1)
  3. mobidb-lite (disord...)

Residue annotation

  1. metal binding site...
  2. active site cd09857
  3. putative 5' ssDNA ...
  4. metal binding site...

Protein sequence

>MCA_03403_1
MGVKGLLPLLKPINNETHINHFSGQTIGVDGYAWLHRAAISCSWDLAYGTATSKYVEYFEKRLELLISNGVTPFIVFDGG
YLPSKQRVEKSRLSSRSDALQKGFKLAANGNKGEAYKYFMKAIDITPAMVTQVINLLIRMNIRYVVAPYEADAQLVYLEK
INEISAIISEDSDLLIFGCKILITKMDNFGHCIVVSRDKFCNCPELRNMSDSQLRAIAIFSGCDYSPGIPSIGLKKASKY
IMQYQTPERALRCMRADNFCIPEDFDKVFEQADLTFQFQRVYSMHERKVVMLNDPCMNLSPEAEIYIGKHIEDDTAQLIA
AGYLDPLSHQPLDVPPNKQTSSTVVSSNRKLVRSKTLSSFFQQSSKASIQISNKSTSISNSHLHSSPIHKTASIKKQSFI
KRRANRVFSAIDNHELDSILSKSFSPASSQSTILDESTNDSPPSTLLNSSSSFSSQSTDVSTSSSSISSAPSSQDAFVSK
FFPLKTQQDESNMVITSDDESDEYNQTISIPSTNTSTPSSITSANSTLSKYLWTPSMDIKFGSSVSNISPGFKFKSPLLS
QSNSLPPSASFSKFRYNSQNFQSPTPNNQSMQKDIVSSSDSESDSDSDSSESSEIETPKKLRVYYQQQAQLKKEQQVKLP
ESPTRSKVTQFSQSINKFRYNLEKQ

GO term prediction

Biological Process

GO:0006281 DNA repair

Molecular Function

GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

Cellular Component

None predicted.