MIA_04157_1

Protein

Length

1,576 amino acids

Protein function

EGGNOG:	0PGF0	ATG26	May be involved in decane metabolism and autophagy. Involved in the biosynthesis of sterol glucoside (By similarity)
SGD closest match:	S000004179	ATG26	Sterol 3-beta-glucosyltransferase
CGD closest match:	CAL0000189652	ATG26	Sterol 3-beta-glucosyltransferase

Protein alignments

	%id	Aln length
MCA_00099_1	55.539%	1354	MCA_00099_1
A0A0J9XGV0_GEOCN	50.886%	1185	Sterol 3-beta-glucosyltransferase OS=Geotrichum candidum GN=BN980_GECA15s02540g PE=3 SV=1
A0A167FDW8_9ASCO	51.416%	1095	Sterol 3-beta-glucosyltransferase OS=Sugiyamaella lignohabitans GN=ATG26 PE=3 SV=1
UniRef50_A0A167FDW8	51.416%	1095	Sterol 3-beta-glucosyltransferase n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167FDW8_9ASCO
A0A060T134_BLAAD	63.353%	674	Sterol 3-beta-glucosyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C13398g PE=3 SV=1
ATG26_YARLI	61.111%	666	Sterol 3-beta-glucosyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG26 PE=3 SV=3
ATG26_YEAST	53.627%	703	Sterol 3-beta-glucosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG26 PE=1 SV=1
A0A1E4THY9_9ASCO	55.589%	662	Sterol 3-beta-glucosyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26867 PE=3 SV=1
ATG26_CANAL	54.348%	644	Sterol 3-beta-glucosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG26 PE=3 SV=2
A0A1E3PTE4_9ASCO	44.159%	856	Sterol 3-beta-glucosyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81477 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0216

Protein family membership

UDP-glucuronosyl/UDP-glucosyltransferase (IPR002213)

Domains and repeats

Domain
157 - 391
PH domain-like (IPR011993)
Pleckstrin homology domain (IPR001849)
889 - 1,022
Glycosyltransferase family 28, N-terminal domain (IPR004276)
Domain
215 - 392
GRAM domain (IPR004182)
703 - 804
GRAM domain (IPR004182)

1 200 400 600 800 1000 1200 1400 1576

Detailed signature matches

IPR002213

UDP-glucuronosyl/UDP-glucosyltransferase
1. PF00201 (UDPGT)
  
  1,133 - 1,294
  
  Pfam
  PF00201 (UDPGT)
IPR011993

PH domain-like
1. G3DSA:2.30.29.30
  
  157 - 379
  
  GENE3D
  G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
2. SSF50729 (PH domain...)
  
  262 - 391
  
  SUPERFAMILY
  SSF50729 (PH domain-like)
IPR004182

GRAM domain
1. PF02893 (GRAM)
  
  704 - 804
  
  Pfam
  PF02893 (GRAM)
  
  223 - 265
  
  Pfam
  PF02893 (GRAM)
2. SM00568 (gram2001c)
  
  215 - 392
  
  SMART
  SM00568 (gram2001c)
  
  703 - 769
  
  SMART
  SM00568 (gram2001c)
IPR001849

Pleckstrin homology domain
1. SM00233 (PH_update)
  
  267 - 369
  
  SMART
  SM00233 (PH_update)
2. PS50003 (PH_DOMAIN)
  
  266 - 367
  
  PROSITE profiles
  PS50003 (PH_DOMAIN)
3. PF00169 (PH)
  
  269 - 366
  
  Pfam
  PF00169 (PH)
IPR004276

Glycosyltransferase family 28, N-terminal domain
1. PF03033 (Glyco_tran...)
  
  889 - 1,022
  
  Pfam
  PF03033 (Glyco_transf_28)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

886 - 1,139

GENE3D
G3DSA:3.40.50.2000 (G3DSA:3.40.50.2000)

1,140 - 1,287

GENE3D
G3DSA:3.40.50.2000 (G3DSA:3.40.50.2000)
SSF53756 (UDP-Glyco...)

886 - 1,305

SUPERFAMILY
SSF53756 (UDP-Glycosyltransferase/glycogen phosphorylase)
cd03784 (GT1_Gtf_like)

886 - 1,302

CDD
cd03784 (GT1_Gtf_like)
cd13216 (PH-GRAM2_A...)

714 - 804

CDD
cd13216 (PH-GRAM2_AGT26)
mobidb-lite (disord...)

80 - 120

MobiDB Lite
mobidb-lite (disorder_prediction)

132 - 167

MobiDB Lite
mobidb-lite (disorder_prediction)

1,483 - 1,576

MobiDB Lite
mobidb-lite (disorder_prediction)

179 - 201

MobiDB Lite
mobidb-lite (disorder_prediction)

1,379 - 1,460

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 62

MobiDB Lite
mobidb-lite (disorder_prediction)

470 - 602

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative lipid bin...

733G

putative lipid binding motif
733G, 734K, 735I
CDD
cd13216 (PH-GRAM2_AGT26)

734K

putative lipid binding motif
733G, 734K, 735I
CDD
cd13216 (PH-GRAM2_AGT26)

735I

putative lipid binding motif
733G, 734K, 735I
CDD
cd13216 (PH-GRAM2_AGT26)
TDP-binding site c...

896G

TDP-binding site
896G, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T
CDD
cd03784 (GT1_Gtf_like)

1,143S

TDP-binding site
896G, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T
CDD
cd03784 (GT1_Gtf_like)

1,215H

TDP-binding site
896G, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T
CDD
cd03784 (GT1_Gtf_like)

1,217G

TDP-binding site
896G, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T
CDD
cd03784 (GT1_Gtf_like)

1,219G

TDP-binding site
896G, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T
CDD
cd03784 (GT1_Gtf_like)

1,220T

TDP-binding site
896G, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T
CDD
cd03784 (GT1_Gtf_like)
active site cd03784

896G

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

897D

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

899Q

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,045E

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,048F

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,049W

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,053S

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,080P

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,143S

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,215H

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,217G

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,219G

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,220T

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)

1,223A

active site
896G, 897D, 899Q, 1,045E, 1,048F, 1,049W, 1,053S, 1,080P, 1,143S, 1,215H, 1,217G, 1,219G, 1,220T, 1,223A
CDD
cd03784 (GT1_Gtf_like)
acceptor substrate...

897D

acceptor substrate-binding pocket
897D
CDD
cd03784 (GT1_Gtf_like)
homodimer interfac...

911E

homodimer interface
911E, 985D, 1,298I, 1,299A, 1,302Y
CDD
cd03784 (GT1_Gtf_like)

985D

homodimer interface
911E, 985D, 1,298I, 1,299A, 1,302Y
CDD
cd03784 (GT1_Gtf_like)

1,298I

homodimer interface
911E, 985D, 1,298I, 1,299A, 1,302Y
CDD
cd03784 (GT1_Gtf_like)

1,299A

homodimer interface
911E, 985D, 1,298I, 1,299A, 1,302Y
CDD
cd03784 (GT1_Gtf_like)

1,302Y

homodimer interface
911E, 985D, 1,298I, 1,299A, 1,302Y
CDD
cd03784 (GT1_Gtf_like)

Protein sequence

>MIA_04157_1
MDKSTSPAAPPADAPAAAAPTKTSSASVATATAVLAAKPEIKSHSNEIEDDEQKRNSSMDLAAVQQSSIGVTLFKLFNES
ANISSHDDTDEDDEDEDEEEDKISQAGDTESLSPVGTETESYVAGHVSKISTNDDASTLKPKASNASNDILSRPVSSTDS
DQQSMSRLTQSIHSLVLTSNRASRRSSKSGAASIKSKTESDYQDEECKKRAGLIAETLRSLGVNDDDVLVADYPCWLLRH
ILLEGRLYVTENDVCFTAFLPSTQGKTLMSGSLSKMAYRGSRLTRSWFVLRPDQLSFYHSAKELYFPLGAIDLRFALQAD
LVPETRGGDKYSSTLFSLVTEQRTHTFKADNPVSAQQWVKSLQRAIFLSRNEGDQVKIKIPVENIVDLEESNLQEFGVAL
KVRAVDSEDTFSIDEYVLAFLHPSKKSEVPLEAIRRVMDKKGIKDINPKIGTEKLVEELSESRRTLGRITDSTYSIGSSP
TAGQSPTRLGSSSPNLYLSDEASSPNRSVTGLGRRMTRRVRNMVSHEGSQSRSASPARLHPGQSNVTSGASPLQKGRAAH
DDDSSILTQEDSYMDITSENLFGDGRSPESPRSRDNSRERHLEEVSPILLATTVGMPSITSTATLQPPAATQSSTSLLPG
FHFGRGHGEAEKKKRVHGTMVHKVSDMFTSSIKHYQKGSDEYVDSEDLEKLLVSDEERKESNKRFQAHFSFGEDEELVAT
YYAHIQKPIPIYGKIYVSMNFVCFRSLIIGTKTKMVVPYKDIENVSAENGFKFGYSGLVIVIHGHEDVFFEFSSKAARDD
CEAVTCKRLDVLRMQGSLTSSSFGGHEEAIHTPQERLRLARLHTYEDSLRSKGNVFEGVNAPAIIESRDHAAPLLQTAEK
PRKTYHFTCVTIGSRGDVQPYIALCKGLLKEGHKCRIATHAEFKDWVESYDIEFREVAGDPGELMKIMIEHGMFSVSFLR
DAASKFRGWIDELLHTTWEACQGSDVIIESPSAMAGIHVAEALKIPYFRAFTMPWTRTRTYPHAFMVPEQKMGGSYNHLT
YVLFENVFWKGISGQVNKWRVKELGLDKTNLELLRQNEVPFLYNVSPSILVPPVDYPDWVRVTGYWFLDEGAADSFKPPQ
DLVDFMATARKDKKKIVYIGFGSIVVSNPAEMTKAVVESVLKAGVRCILSKGWSERFGDKDAANKMEVPLPKDIFQIKSA
PHDWLFPQIDAAVHHGGSGTTGASLRAGLPTIIKPFFGDQFFYAGRVEDLGVGVCLKKLTVSAFSKAIVEVTTNEKMIKK
AKLLGGKIRKEHGVDTAIALIYWQMDYALSLVEKRRQEEIAKEHDSFGITGILSPVGGAISRTFTASAEHAGALASLAYR
PLLEVSGVGTNNNNINSAATQSAPGLVQSSASSTSRGFLHRTGSTNNLPESNEASSNKTSVALRPVRTLRKIIGHSDGDD
ETESESEVSVSTSSAASVVEDDKTCVRTASNCAGTVLSTITSRTRSSLPFSHSSRTNSVASNSSTGSHSGHGHHHHHHLG
GIHAGHGGRHSVHGIHGSRHSIHKSSVGGSASSSSEDTHKTDESWTFVGDDDDDSN

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
GO:0030259 lipid glycosylation

Molecular Function

GO:0016758 transferase activity, transferring hexosyl groups

Cellular Component

None predicted.

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Entry type

Status

Per-residue features