MCA_00099_1

Protein

Length

1,475 amino acids

Gene name: ATG26

Description: Sterol 3-beta-glucosyltransferase

Browser: contigA:269317-273812+

RNA-seq: read pairs 2742, FPKM 23.0, percentile rank 45.1% (100% = highest expression)

Protein function

Annotation:		ATG26	Sterol 3-beta-glucosyltransferase
KEGG:	K05841	E2.4.1.173	sterol 3beta-glucosyltransferase [EC:2.4.1.173]
EGGNOG:	0PGF0	ATG26	May be involved in decane metabolism and autophagy. Involved in the biosynthesis of sterol glucoside (By similarity)
SGD closest match:	S000004179	ATG26	Sterol 3-beta-glucosyltransferase
CGD closest match:	CAL0000189652	ATG26	Sterol 3-beta-glucosyltransferase

Protein alignments

	%id	Aln length
MIA_04157_1	71.07%	681	MIA_04157_1
A0A167FDW8_9ASCO	64.48%	656	Sterol 3-beta-glucosyltransferase OS=Sugiyamaella lignohabitans GN=ATG26 PE=3 SV=1
UniRef50_A0A167FDW8	64.48%	656	Sterol 3-beta-glucosyltransferase n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167FDW8_9ASCO
A0A0J9XGV0_GEOCN	63.06%	674	Sterol 3-beta-glucosyltransferase OS=Geotrichum candidum GN=BN980_GECA15s02540g PE=3 SV=1
A0A060T134_BLAAD	62.26%	665	Sterol 3-beta-glucosyltransferase OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C13398g PE=3 SV=1
ATG26_YARLI	58.61%	674	Sterol 3-beta-glucosyltransferase OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=ATG26 PE=3 SV=3
ATG26_YEAST	56.10%	631	Sterol 3-beta-glucosyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ATG26 PE=1 SV=1
A0A1E4THY9_9ASCO	51.99%	679	Sterol 3-beta-glucosyltransferase OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_26867 PE=3 SV=1
ATG26_CANAL	50.77%	717	Sterol 3-beta-glucosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ATG26 PE=3 SV=2
A0A1E3PTE4_9ASCO	41.96%	877	Sterol 3-beta-glucosyltransferase (Fragment) OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_81477 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0604

Protein family membership

UDP-glucuronosyl/UDP-glucosyltransferase (IPR002213)

Domains and repeats

Domain
52 - 375
PH domain-like (IPR011993)
Pleckstrin homology domain (IPR001849)
730 - 823
PH domain-like (IPR011993)
893 - 1,028
Glycosyltransferase family 28, N-terminal domain (IPR004276)
Domain
212 - 277
GRAM domain (IPR004182)
715 - 821
GRAM domain (IPR004182)

1 200 400 600 800 1000 1200 1475

Detailed signature matches

IPR002213

UDP-glucuronosyl/UDP-glucosyltransferase
1. PF00201 (UDPGT)
  
  1,124 - 1,285
  
  Pfam
  PF00201 (UDPGT)
IPR011993

PH domain-like
1. G3DSA:2.30.29.30
  
  730 - 823
  
  GENE3D
  G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
  
  52 - 375
  
  GENE3D
  G3DSA:2.30.29.30 (G3DSA:2.30.29.30)
2. SSF50729 (PH domain...)
  
  238 - 370
  
  SUPERFAMILY
  SSF50729 (PH domain-like)
IPR004182

GRAM domain
1. SM00568 (gram2001c)
  
  715 - 781
  
  SMART
  SM00568 (gram2001c)
  
  212 - 277
  
  SMART
  SM00568 (gram2001c)
2. PF02893 (GRAM)
  
  716 - 821
  
  Pfam
  PF02893 (GRAM)
IPR001849

Pleckstrin homology domain
1. SM00233 (PH_update)
  
  264 - 365
  
  SMART
  SM00233 (PH_update)
2. PS50003 (PH_DOMAIN)
  
  263 - 363
  
  PROSITE profiles
  PS50003 (PH_DOMAIN)
3. PF00169 (PH)
  
  267 - 362
  
  Pfam
  PF00169 (PH)
IPR004276

Glycosyltransferase family 28, N-terminal domain
1. PF03033 (Glyco_tran...)
  
  893 - 1,028
  
  Pfam
  PF03033 (Glyco_transf_28)

no IPR

Unintegrated signatures

G3DSA:3.40.50...

1,136 - 1,294

GENE3D
G3DSA:3.40.50.2000 (G3DSA:3.40.50.2000)

885 - 1,135

GENE3D
G3DSA:3.40.50.2000 (G3DSA:3.40.50.2000)
SSF53756 (UDP-Glyco...)

892 - 1,308

SUPERFAMILY
SSF53756 (UDP-Glycosyltransferase/glycogen phosphorylase)
cd03784 (GT1_Gtf_like)

892 - 1,306

CDD
cd03784 (GT1_Gtf_like)
cd13215 (PH-GRAM1_A...)

244 - 362

CDD
cd13215 (PH-GRAM1_AGT26)
cd13216 (PH-GRAM2_A...)

726 - 817

CDD
cd13216 (PH-GRAM2_AGT26)
mobidb-lite (disord...)

501 - 661

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 24

MobiDB Lite
mobidb-lite (disorder_prediction)

1,399 - 1,475

MobiDB Lite
mobidb-lite (disorder_prediction)

40 - 154

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

putative lipid bin...

272K

putative lipid binding motif
272K, 283N, 284W, 285Y
CDD
cd13215 (PH-GRAM1_AGT26)

283N

putative lipid binding motif
272K, 283N, 284W, 285Y
CDD
cd13215 (PH-GRAM1_AGT26)

284W

putative lipid binding motif
272K, 283N, 284W, 285Y
CDD
cd13215 (PH-GRAM1_AGT26)

285Y

putative lipid binding motif
272K, 283N, 284W, 285Y
CDD
cd13215 (PH-GRAM1_AGT26)
putative lipid bin...

745G

putative lipid binding motif
745G, 746K, 747I
CDD
cd13216 (PH-GRAM2_AGT26)

746K

putative lipid binding motif
745G, 746K, 747I
CDD
cd13216 (PH-GRAM2_AGT26)

747I

putative lipid binding motif
745G, 746K, 747I
CDD
cd13216 (PH-GRAM2_AGT26)
TDP-binding site c...

902G

TDP-binding site
902G, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T
CDD
cd03784 (GT1_Gtf_like)

1,148S

TDP-binding site
902G, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T
CDD
cd03784 (GT1_Gtf_like)

1,219H

TDP-binding site
902G, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T
CDD
cd03784 (GT1_Gtf_like)

1,221G

TDP-binding site
902G, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T
CDD
cd03784 (GT1_Gtf_like)

1,223G

TDP-binding site
902G, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T
CDD
cd03784 (GT1_Gtf_like)

1,224T

TDP-binding site
902G, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T
CDD
cd03784 (GT1_Gtf_like)
active site cd03784

902G

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

903D

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

905Q

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,051D

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,054F

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,055W

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,059S

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,086P

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,148S

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,219H

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,221G

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,223G

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,224T

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)

1,227A

active site
902G, 903D, 905Q, 1,051D, 1,054F, 1,055W, 1,059S, 1,086P, 1,148S, 1,219H, 1,221G, 1,223G, 1,224T, 1,227A
CDD
cd03784 (GT1_Gtf_like)
acceptor substrate...

903D

acceptor substrate-binding pocket
903D
CDD
cd03784 (GT1_Gtf_like)
homodimer interfac...

917E

homodimer interface
917E, 991D, 1,302I, 1,303A, 1,306Y
CDD
cd03784 (GT1_Gtf_like)

991D

homodimer interface
917E, 991D, 1,302I, 1,303A, 1,306Y
CDD
cd03784 (GT1_Gtf_like)

1,302I

homodimer interface
917E, 991D, 1,302I, 1,303A, 1,306Y
CDD
cd03784 (GT1_Gtf_like)

1,303A

homodimer interface
917E, 991D, 1,302I, 1,303A, 1,306Y
CDD
cd03784 (GT1_Gtf_like)

1,306Y

homodimer interface
917E, 991D, 1,302I, 1,303A, 1,306Y
CDD
cd03784 (GT1_Gtf_like)

Protein sequence

>MCA_00099_1
MSDNSQTKDEGSTSSAHKRPTSMDLSAVKSSVGVALFKLINDNAATDTEFEDEYDGEEDEEDEEDQDGEYDKYLSEDEQS
NAPTTLQDPVNLNSESKLDDKSEYSKTSTKADSTDIHSYKSSSSFHAHSSLQKSKTELSASPKANDYQRTSSMPTYKLET
DYDDTECNSKLNQSIQSLVMDSKPSRRSKKSKLSTLNAIPDEECKHRAALIADTLRTLGVNDDDVLVGDYPCWLLRHILL
EGRLYITSSLVCFNAFLPSSQGKTILTGTLTKLSKRSVRYSRNWYILKSDTLSFYNSSTDVYFPVGSIDLRYALQADLVP
NSSGDKFKSKAFKLVTEKRTYIFKTDTVENAQLWVKSLQNVIFLAHNRGDRVTIKIPIENIIDLEESNLNEFGKALKLRA
IDSDETFSIDEYVLAFLHPSQKFEVPLNAIRRVMEQKGIENIKTTNIPSEQLFEEIAETRKTLGKVTDSTNSFNALDMQE
SASPTAESNDEFFPFSYFSPGRKTSKRSTLETESNASGLSKGSGPSLIHPKPLSFPPSVRSGSSRPMSPVSDTRSSSTLN
TNISSSKQHLGTELLGPAFTETQEDHTKPKERPSSVFLNSLSFGNRRNKSPSRSSSPSSMMDSQDSFLDLSKEKNMQSHS
RPASPSVSAEHSKSADLETKRKKRATIVHKLGEMFSSSIKHYHTTDNIYNLKDGDGDEDFEKYMMSEDETNESNERFRSH
FSFGEDEELVATYYAHIQKPYPIYGKIYLSNGHICFRSLMIGSKTKMILPLKDVENVSSENGFKFGYSGLVFIIHGHEEV
FFEFSSRSARDDCESTVRRLLDIKKMTGSGLANSTIFADVDPSEKLRIARLQAYEKHLREDGTLEGLDNAKAIVFSDPNC
IEKEEPPIRSLHFTMLTIGSRGDVQPYIALCKGLMKEGHKCRIATHIEFKDWIESYGIEFRTIAGDPGELMKIMIEHGML
SVSFLRDAASKFRGWIDELLHTSWLASQGTDVLIESPSAMAGLHVAEALQIPYFRAFTMPWTRTRTYPHAFMVPEQKLGG
SYNHLTYVLFDNVFWKGISGQINKWRVRELGLEKTNLDLMQQGRVPFLYNVSPSVLVPPVDYADWVKVTGYWFLDEGNKD
YKPPKELVDFIAKAKKDKKKIVYIGFGSIVVSDSTEMTKTVIEAVKQSGVRCILSKGWSERYNAPDSANVEVPLPPEIHL
IKSAPHDWLFPQMDAAVHHGGSGTTGASLRAGLPTVIKPFFGDQFFYAGRVEDLGVGVCLRKLSVNAFSKALIEVTTNEK
IIKKSYAIGCKIRKEDGVSTAIASIYWEMDYATSLIKKRKPKDSASKVIQDGASDSSIPVINLDVTSEGNSSTEKIENED
CTSTLKSVGGTIRRSLSTSSRIPQDIANGAISSLKHVFSSHGSSSRSSSPSRANSDFKNFLVPGSPLTKETTLEKEIDTK
KKSSINTNDNSAGSYSSDEAQKTDESWTLLDEESS

GO term prediction

Biological Process

GO:0005975 carbohydrate metabolic process
GO:0008152 metabolic process
GO:0030259 lipid glycosylation

Molecular Function

GO:0016758 transferase activity, transferring hexosyl groups

Cellular Component

None predicted.

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Entry type

Status

Per-residue features