Protein

MIA_04154_1

Length
1,171 amino acids

Browser: contig05:918777-922359+

Protein function

EGGNOG:0PGM5RAT1Possesses 5'- 3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity)
SGD closest match:S000005574RAT15'-3' exoribonuclease 2
CGD closest match:CAL0000180194RAT15'-3' exoribonuclease 2

Protein alignments

%idAln lengthE-value
MCA_00097_163.921%9590.0MCA_00097_1
A0A060T152_BLAAD65.675%5040.0ARAD1C21560p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C21560g PE=4 SV=1
A0A167EJM5_9ASCO65.646%4570.0SsRNA exonuclease RAT1 OS=Sugiyamaella lignohabitans GN=RAT1 PE=4 SV=1
UniRef50_A0A167EJM565.646%4570.0SsRNA exonuclease RAT1 n=1 Tax=Sugiyamaella lignohabitans TaxID=796027 RepID=A0A167EJM5_9ASCO
A0A0J9X3M5_GEOCN59.533%5140.0Similar to Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease OS=Geotrichum candidum GN=BN980_GECA01s11043g PE=4 SV=1
XRN2_YEAST53.968%5042.77e-1725'-3' exoribonuclease 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAT1 PE=1 SV=3
XRN2_CANAL53.663%5052.23e-1715'-3' exoribonuclease 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAT1 PE=3 SV=4
XRN2_YARLI48.855%5241.01e-1445'-3' exoribonuclease 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RAT1 PE=3 SV=3

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.3291

Protein family membership

Domains and repeats

  1. Domain
1 200 400 600 800 1000 1171

Detailed signature matches

  1. Family IPR017151
    5'-3' exoribonuclease type 2
    1. PIRSF037239 (Exonuc...)
  2. Domain IPR004859
    Putative 5-3 exonuclease
    1. PF03159 (XRN_N)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:3.30.70...
  3. mobidb-lite (disord...)

Protein sequence

>MIA_04154_1
MFFSTLPFIRHYNPKIFDTKFLSDGSEGFLLQRLPALPNKPPHHHQPSWAFFRWLSRKYPKTVSPVLEEPDVEIDGITYP
PNYANPNPNDELDNLYLDMNGIVHPCTHPEGREAPKNEDEMMLEVFKYTDRVLTMARPRKILMIAIDGVAPRAKMNQQRS
RRFRTARESRINAEAKEQAINEAEARGEIIDDAIKGKTRWDSNVITPGTPFMDTLAISLRYWIAFKLNSDPGWRDLKIII
SDASVPGEGEHKIMEFIRSQRADPSHDPNTSHCIYGLDADLIFLGLATHEPHFKILREDVFAQQNKPQPGPNKNFGLTEE
DKKKLDLDAQLEKSHKKPFIWLHVDLLRQYLEIELAVPNLPFAYDFERAIDDWVFMCFFCGNDFLPHLPSLDVRSNSIDM
LTDMWRRNLAKLKGFITCDGRVDLDRAEVLLRSLGQQEDNIFRSKIRVEEDRKKRRLDDEKRKEQKEMDPKMLKEMLQKQ
EHNYSPAQQLEETILDQKVSQPEISKNRTGDRAPVHPLDNIPLYSPSGESVGAVHMSNSELVARRNEITMVNIANKAAAD
ALKAKLKNDKKGKNSKSALEEQKDDKKKEPEEEEEENENNDDEGEENEETEETEDSEAPKPPPVKIGVKRGHDGFERRDD
IDQYADPIRLGEPGYRDRYYTLKFDAPEENQARRRDIVERYIEGVCWVLLYYYQGCPSWNWYFPYHYAPFAVDFINLSKI
EIKFNKGEPFAPYEQLMSVLPASSGHTLPEVFRPLMSDPKSEIIDFYPEDFQIDLNGKKFEWQGVAILPFIDEKRLLTAV
RSKYDQLTPQEVARNTRKNEILIVSSHNVIYEQAMKKVYATDADKDSRFNFRAFQTKGLTGTISKDEAFENKEIFNFPLS
EGHMPDVPLTGNVMFLTYDMPVSSFPNKSMLLRGVKLRDPIFTQTEETIIRQKISERRNRHNNNNYNNSNNGLGRNEPLK
VPGRIGGYVNYLGLEQTGQLPGSDLQTRQGIRGSFIGNGGHYYNNNGGGYGGNNNNNYRGNLYNGNNGGYNGGSRNGDGN
GYQRNGDGNGYQRNGGYNYNNNGNGGRQNNTMGRQQGGGYQHRDTGNNNGYGGGHNQGYNQYQSYGQQHYAPTANQPFAS
NAFGSVGTNNRNDKAGHGNNNYRGNSNYNNGGRGGGGYRGNNNRNNRYNNR

GO term prediction

Biological Process

GO:0006139 nucleobase-containing compound metabolic process

Molecular Function

GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0004534 5'-3' exoribonuclease activity

Cellular Component

GO:0005634 nucleus