Protein
MCA_00097_1
Length
1,124 amino acids
Gene name: RAT1
Description: 5'-3' exoribonuclease 2
Browser: contigA:258794-262169+
RNA-seq: read pairs 3618, FPKM 39.7, percentile rank 60.2% (100% = highest expression)
Protein function
| Annotation: | RAT1 | 5'-3' exoribonuclease 2 | |
|---|---|---|---|
| KEGG: | K12619 | XRN2 | 5'-3' exoribonuclease 2 [EC:3.1.13.-] |
| EGGNOG: | 0PGM5 | RAT1 | Possesses 5'- 3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity) |
| SGD closest match: | S000005574 | RAT1 | 5'-3' exoribonuclease 2 |
| CGD closest match: | CAL0000180194 | RAT1 | 5'-3' exoribonuclease 2 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04154_1 | 63.80% | 953 | 0.0 | MIA_04154_1 |
| A0A060T152_BLAAD | 56.66% | 886 | 0.0 | ARAD1C21560p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C21560g PE=4 SV=1 |
| A0A0J9X3M5_GEOCN | 53.62% | 897 | 0.0 | Similar to Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease OS=Geotrichum candidum GN=BN980_GECA01s11043g PE=4 SV=1 |
| UniRef50_A0A0J9X3M5 | 53.62% | 897 | 0.0 | Similar to Saccharomyces cerevisiae YOR048C RAT1 Nuclear 5' to 3' single-stranded RNA exonuclease n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9X3M5_GEOCN |
| A0A167EJM5_9ASCO | 56.07% | 840 | 0.0 | SsRNA exonuclease RAT1 OS=Sugiyamaella lignohabitans GN=RAT1 PE=4 SV=1 |
| XRN2_CANAL | 48.14% | 889 | 0.0 | 5'-3' exoribonuclease 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=RAT1 PE=3 SV=4 |
| XRN2_YARLI | 43.63% | 926 | 0.0 | 5'-3' exoribonuclease 2 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=RAT1 PE=3 SV=3 |
| XRN2_YEAST | 53.62% | 511 | 2e-176 | 5'-3' exoribonuclease 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RAT1 PE=1 SV=3 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.9352
Predicted cleavage: 18
Protein family membership
- 5'-3' exoribonuclease type 2 (IPR017151)
Domains and repeats
-
Domain
1
200
400
600
800
1000
1124
Detailed signature matches
-
-
PIRSF037239 (Exonuc...)
-
-
-
PF03159 (XRN_N)
-
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MCA_00097_1 MGVPAFFRWISRKYPKIVSQVIDNDEVDVNGVRIPEPYSNPNPNGELDNLYLDMNGIVHPCTHPEGREPPKNEDEMMLEV FKYTDHVISMARPRKLLMIAVDGVAPRAKMNQQRSRRFRSAREARINSETKEAAIQEAEARGEIIDDAIKNKTQWDSNSI TPGTPFMDLLAQSLRYWISYKLSTDEGWKDLKVIISDASVPGEGEHKLMEFIRTQRADPSYDPNTTHCIYGLDADLIFLG LATHEPHFKILREDVFAQSEKKERKPAGFGLTKEDQERIEAEEKFEKQKKKPFIWLHVDILRQYLEIELAVPRLPFHYDF ERALDDWVFMCFFCGNDFLPHLPCLEVRSNSVDILTDMWRRNLAQMGGFMTCDGDVNLERAEIFLKVLANQEDNIYRSRL RQEEERKRRHIERESKPKFDASHIEDALIRPAEESKTVNSSPSLPNIPEPTIIPLSKSRSGDRAPINPLDNIPLYTPSGE SVGAVHMTNSELVANRNKITMANIANKTAAEALKNSLKKSKTTKVTATKVNQETTAPIADSIEAVLPSDDEKNDDDDDDD DTPTEDSTLNSPIMAGQKRTIDGTPKSATSEIREDMDQYADPIRFGEPGYRDRYYTLKFDAPESNPERRRDIVEKYMEGV CWVLKYYYQGCASWDWYFPYHYAPLAADFVRLKDIKIDFDEGTPILPYEQLMSVMPAASSHTLPPQFHRLMSSPDSEIID FYPEDFVIDLNGKKFEWQGVAILPFIDKSRLLDAVQKVYPDLSQAERERNTRKNEVLLISRHNVLFEQAKSKIYSDESEG GKTLFGIRCFESGGLSGIISKDPYFDIKSLIKYPLKEGYMPDIDPSTSVLSLTYDMPPLLNKNKSMLLPGVKLRPPVFTP SEEAVIKTKITERRRGGRNENNNAMHGNNALGRNEHLKVSGFQGGYVNFVESEKTGQLPGSDLQTRQGFTGNFNSGGSGR SNYYDNRNNYNNNNNYRNNHNNNGGHYNNRNRPDGGYQQGGYNNNRNNYNNNYNNYNNNRNSGNYYNNRDSHSNYDQGSY NNNRGYNNSRQSNYNNNRPPQGGYNNNYQSQQQHSLNPAMPFGTNMFGHVGNTPNNNNNNNSNNRYNNSNSGNYNNNYRR NNYN
GO term prediction
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
Molecular Function
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0004534 5'-3' exoribonuclease activity
Cellular Component
GO:0005634 nucleus