Protein
MIA_04139_1
Length
1,501 amino acids
Browser: contig05:878954-883555+
Protein function
| EGGNOG: | 0PFNW | SPT6 | Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression |
|---|---|---|---|
| SGD closest match: | S000003348 | SPT6 | Transcription elongation factor SPT6 |
| CGD closest match: | CAL0000194756 | SPT6 | Transcription elongation factor SPT6 |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_00081_1 | 65.10% | 1315 | 0.0 | MCA_00081_1 |
| A0A0J9XH61_GEOCN | 57.68% | 1328 | 0.0 | Similar to Saccharomyces cerevisiae YGR116W SPT6 Nucleosome remodeling protein, functions in various aspects of transcription, chromatin maintenance, and RNA processing OS=Geotrichum candidum GN=BN980_GECA17s01561g PE=4 SV=1 |
| A0A170QYV0_9ASCO | 53.60% | 1334 | 0.0 | Chromatin-remodeling histone chaperone SPT6 OS=Sugiyamaella lignohabitans GN=SPT6 PE=4 SV=1 |
| UniRef50_A0A170QYV0 | 53.60% | 1334 | 0.0 | Chromatin-remodeling histone chaperone SPT6 n=3 Tax=Saccharomycetales TaxID=4892 RepID=A0A170QYV0_9ASCO |
| A0A060TA59_BLAAD | 52.40% | 1334 | 0.0 | ARAD1D24530p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D24530g PE=4 SV=1 |
| W0TYP5_YARLI | 44.63% | 1331 | 0.0 | YALI0B01224p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_B01224g PE=4 SV=1 |
| A0A1E4TBX0_9ASCO | 42.71% | 1344 | 0.0 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_28947 PE=4 SV=1 |
| A0A1E3PFS8_9ASCO | 50.55% | 1007 | 0.0 | Uncharacterized protein OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_83784 PE=4 SV=1 |
| SPT6_CANAL | 36.03% | 1335 | 0.0 | Transcription elongation factor SPT6 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SPT6 PE=3 SV=1 |
| SPT6_YEAST | 34.95% | 1385 | 0.0 | Transcription elongation factor SPT6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPT6 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0009
Protein family membership
- Transcription elongation factor Spt6 (IPR017072)
Domains and repeats
-
Domain
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Domain
1
200
400
600
800
1000
1200
1400
1501
Detailed signature matches
no IPR
Unintegrated signatures
-
-
-
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SSF158832 (Tex N-te...)
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mobidb-lite (disord...)
Residue annotation
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phosphotyrosine bi...
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hydrophobic bindin...
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phosphotyrosine bi...
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hydrophobic bindin...
Protein sequence
>MIA_04139_1 MSDEYDEEQQFSEKEEGFRDDENDDEENPRSDNEIDTSEEEEDDEEELEKIKEGFIVDDEEEEEEEDDDIEGARRKRRKK KRRHRSRSDDEEEDEEGSRGRNKIEDDLDEDDLDLLMENTGRVVEKPSNSRQFKRLKRANQEEDSRSRGLNDMFSDEEEG ESSNRPPEKQPFASEFDDFIEEDQFSDEDQIQEDENRRRHVPKPSRGSSALGAQYQGLDEDKLQELFEVFGDGTEYEWAL EGEDMLEQGLNYSDEEVEKLGPNLKDIFEPGELSAKLLTDEDNAIRAKDLPERYQIMRANYKDDYLLTEPEFADEVRWVI SKLSAEKSSLFFSKPYLRDPFQTAVEKVLEFISREDLEIPFIWHHRKDFLVYALPNQRENNEDGEEPVTNMSKPVTEELL TLDDLWHIVHLDIEYHGIYLKSRSVQKVYDSLVIYDSTYSSLFPTASSLVDYQDLMDYIQFKYSSKIKDQTIGTSLPNNH ETLKKRSRYARFEKIRDGPVYSLVNSFGISAEKVGENIATSTRLYYAEDNASSPLTLAERCFESHIGESDFNLYTTPQQV LDDAQAMLVEEFFHDPRIRKSLREKFWEKAKVDIILTDKGRKQIDEGSPYNDIKYAINKSFRDLRLRPQTYLHMLKAESE GLVIVRISYPRYKETLFEELFTQYIASDNVSDISKEWNEVRREIFKSTSRRIIPHICNTIKEDLRVECTRSLYYEVRRSF SKCLDQAPYQPYGYSPGATPRIITLSWGMGEIGKDAILAAVLDEYGEVLEFAKFEDPRSEQFKAQFVSLVNRRNPDVVGI AGFTVPSNRLFQIVDDIIKKEELTAGSDMASASPLKLIWVQDEVARIYQNSERAVAEFPDQVKLSLYCIGLARYVQSPLL EYAALKENIKDIRIHPFQDLLSESDLENAIETVFVDFVNMVGVDINEAVRTPYIANLLPYIAGLGPRKASTMLQGIQSHG GSLTNRTELVTRGITGKIIFMNCSSFIIIPYEEDRPVSYDLVEVLDATRIHPQDYLIARKIAADALELDEEDIEAYEGQG GVVAYLINNKETDKLNELLLDEYAKELEKEFNQKKRETLEMIKDELQHRYHELRKPFHILSEMEVFVMLTQETKDTIHKG AVVPMNIRRVGDRFLSGQLSSGIEANVSLANMFDPGAEAPHPSTVFNFGQTVQGVILDINYTKFTAELSTAPSAIREIQE KRRTQKKDPKYWNVEAEEEEKRKLAQKKEAEQRATRIINHPLFKPFNARQAEEYLATMPNGSVVIRPSSRGYDHIAVTWK VADGIFQHLDVLELDKQNDFSIGNTLQVGSHKYSDLDELVVMHVQSMARKVEQMVNHEKFLKKPRPEVENWLRTYTKSNP QRSVYAFCYDHKRPGYFSLMYQTGASTPVQSLAVKVIPGGYSLLNHSYPGVNELINGFKTIMNNQMMSDMSRHQHRGGAG GGGSSAYGGPPGYGNGGGRGNGYGVGAPPPSRYGGGVGGSRDHFREGYSRDPRQRDRFYGR
GO term prediction
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032784 regulation of DNA-templated transcription, elongation
Molecular Function
GO:0000991 transcription factor activity, core RNA polymerase II binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
Cellular Component
None predicted.