Protein

MIA_04125_1

Length
317 amino acids

Browser: contig05:830966-832023+

Protein function

EGGNOG:0PJ9YGLO2Hydroxyacylglutathione hydrolase
SGD closest match:S000002680GLO2Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
CGD closest match:CAL0000189186GLO2Hydroxyacylglutathione hydrolase

Protein alignments

%idAln lengthE-value
MCA_00067_173.462%2604.31e-150MCA_00067_1
A0A0J9XHQ0_GEOCN73.462%2601.37e-148Similar to Saccharomyces cerevisiae YDR272W GLO2 Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate OS=Geotrichum candidum GN=BN980_GECA17s02452g PE=3 SV=1
A0A1E3PIJ8_9ASCO56.849%2921.37e-124Metallo-hydrolase/oxidoreductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51718 PE=3 SV=1
UniRef50_A3LU6461.923%2601.55e-115Hydroxyacylglutathione hydrolase n=15 Tax=Saccharomycetales TaxID=4892 RepID=A3LU64_PICST
A0A1D8PID4_CANAL57.143%2731.78e-116Hydroxyacylglutathione hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GLO2 PE=4 SV=1
Q6CA02_YARLI58.846%2602.51e-112YALI0D06974p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06974g PE=4 SV=1
A0A1E4TE50_9ASCO56.322%2616.01e-109Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1770 PE=3 SV=1
A0A060T838_BLAAD53.333%2851.35e-108ARAD1D07656p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07656g PE=3 SV=1
GLO2_YEAST48.561%2785.02e-85Hydroxyacylglutathione hydrolase, cytoplasmic isozyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO2 PE=1 SV=1
A0A167CLB3_9ASCO57.282%1031.38e-34Hydroxyacylglutathione hydrolase GLO2 OS=Sugiyamaella lignohabitans GN=GLO2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.8107
Predicted cleavage: 71

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 250 317

Detailed signature matches

  1. Family IPR017782
    Hydroxyacylglutathione hydrolase
    1. MF_01374 (Glyoxalase_2)
  2. Domain IPR001279
    Metallo-beta-lactamase
    1. SM00849 (Lactamase_...)
    2. PF00753 (Lactamase_B)
    3. G3DSA:3.60.15.10
    4. SSF56281 (Metallo-h...)
  3. Domain IPR035680
    Hydroxyacylglutathione hydrolase, MBL domain
    1. cd07723 (hydroxyacy...)
  4. Domain IPR032282
    Hydroxyacylglutathione hydrolase, C-terminal domain
    1. PF16123 (HAGH_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. NON_CYTOPLASM... (N...)
  3. SIGNAL_PEPTIDE (Sig...)
  4. SIGNAL_PEPTID... (S...)
  5. SIGNAL_PEPTID... (S...)
  6. SIGNAL_PEPTID... (S...)
  7. TMhelix

Residue annotation

  1. metal binding site...
  2. metal binding site...
  3. active site cd07723
  4. metal binding site...

Protein sequence

>MIA_04125_1
MAVIAFKHLLVIPIALVLIVFFDMHSVFSKALRSLRSQSLISASLTVQSPLATTTRAMHVRSIPMRWGTGDNYAYVLTDD
STKNSWVIDPAEPHEVLPVLQKLEQEGEIKLVAIVNTHHHYDHAGGNEELSKHYPGLPIIAGKQSPLVTTTPAHNEQLAL
GSNVAIRALHTPCHTQDSICYYAEDKVSGDKVVFTGDTLFIAGCGRFFEGNAREMDHALNTVLGGLPNETLVYPGHEYTK
SNVKFVESVMNKSTHPALEALANYVTIHEKTTGVFTIGDEKKYNPFMRLQDPELQKATGTQEREDVMAKLRELKNKM

GO term prediction

Biological Process

GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Molecular Function

GO:0004416 hydroxyacylglutathione hydrolase activity

Cellular Component

None predicted.