Protein

MCA_00067_1

Length
260 amino acids

Gene name: GLO2

Description: Hydroxyacylglutathione hydrolase, cytoplasmic isozyme

Browser: contigA:165255-166202+

RNA-seq: read pairs 3910, FPKM 185.1, percentile rank 87.2% (100% = highest expression)

Protein function

Annotation:GLO2Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
KEGG:K01069E3.1.2.6 hydroxyacylglutathione hydrolase [EC:3.1.2.6]
EGGNOG:0PJ9YGLO2Hydroxyacylglutathione hydrolase
SGD closest match:S000002680GLO2Hydroxyacylglutathione hydrolase, cytoplasmic isozyme
CGD closest match:CAL0000189186GLO2Hydroxyacylglutathione hydrolase

Protein alignments

%idAln lengthE-value
MIA_04125_173.46%2602e-148MIA_04125_1
A0A0J9XHQ0_GEOCN70.77%2608e-137Similar to Saccharomyces cerevisiae YDR272W GLO2 Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate OS=Geotrichum candidum GN=BN980_GECA17s02452g PE=3 SV=1
A0A1E3PIJ8_9ASCO62.60%2622e-120Metallo-hydrolase/oxidoreductase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_51718 PE=3 SV=1
UniRef50_A3LU6462.45%2611e-111Hydroxyacylglutathione hydrolase n=15 Tax=Saccharomycetales TaxID=4892 RepID=A3LU64_PICST
Q6CA02_YARLI58.85%2601e-111YALI0D06974p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_D06974g PE=4 SV=1
A0A1D8PID4_CANAL58.46%2602e-109Hydroxyacylglutathione hydrolase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=GLO2 PE=4 SV=1
A0A1E4TE50_9ASCO56.70%2613e-107Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_1770 PE=3 SV=1
A0A060T838_BLAAD56.54%2606e-103ARAD1D07656p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1D07656g PE=3 SV=1
GLO2_YEAST51.08%2783e-87Hydroxyacylglutathione hydrolase, cytoplasmic isozyme OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLO2 PE=1 SV=1
A0A167CLB3_9ASCO58.25%1035e-34Hydroxyacylglutathione hydrolase GLO2 OS=Sugiyamaella lignohabitans GN=GLO2 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1471
Predicted cleavage: 14

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 50 100 150 200 260

Detailed signature matches

  1. Family IPR017782
    Hydroxyacylglutathione hydrolase
    1. MF_01374 (Glyoxalase_2)
  2. Domain IPR001279
    Metallo-beta-lactamase
    1. SM00849 (Lactamase_...)
    2. PF00753 (Lactamase_B)
    3. G3DSA:3.60.15.10
    4. SSF56281 (Metallo-h...)
  3. Domain IPR035680
    Hydroxyacylglutathione hydrolase, MBL domain
    1. cd07723 (hydroxyacy...)
  4. Domain IPR032282
    Hydroxyacylglutathione hydrolase, C-terminal domain
    1. PF16123 (HAGH_C)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil

Residue annotation

  1. metal binding site...
  2. active site cd07723
  3. metal binding site...
  4. metal binding site...

Protein sequence

>MCA_00067_1
MQIRSIPMRWGTGDNYAYLLTDDATKNSWVIDPAEPDEVLPVLKRLEKNGDINLVAIVNTHHHYDHAGGNEDMLASYPGL
PVIAGKESPLVSLTPAHESKLSLGKNIEITALHTPCHTQDSICYYAVDKISNQGVVFTGDTLFNAGCGRFFEGTAKEMDI
ALNKVLGSLPNSTYVYPGHEYTKSNLKFVETVMDKTKNDALAKIVDYVKHHEKTTGVFTIGDEKRYNPFMMLEDKDIQEV
TESEDRAQVMAKLRELKNKM

GO term prediction

Biological Process

GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione

Molecular Function

GO:0004416 hydroxyacylglutathione hydrolase activity

Cellular Component

None predicted.