Protein

MIA_04113_1

Length
857 amino acids

Browser: contig05:799223-801797-

Protein function

EGGNOG:0PGWDNIP1Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity)
SGD closest match:S000004926NIP1Eukaryotic translation initiation factor 3 subunit C
CGD closest match:CAL0000176830NIP1Eukaryotic translation initiation factor 3 subunit C

Protein alignments

%idAln lengthE-value
MCA_00122_168.999%7290.0MCA_00122_1
A0A0J9X4G8_GEOCN58.887%7370.0Eukaryotic translation initiation factor 3 subunit C OS=Geotrichum candidum GN=NIP1 PE=3 SV=1
A0A167EKD9_9ASCO55.319%7520.0Eukaryotic translation initiation factor 3 subunit C OS=Sugiyamaella lignohabitans GN=NIP1 PE=3 SV=1
A0A060TDK6_BLAAD55.795%7420.0Eukaryotic translation initiation factor 3 subunit C OS=Blastobotrys adeninivorans GN=NIP1 PE=3 SV=1
A0A1E3PS68_9ASCO51.569%7330.0Eukaryotic translation initiation factor 3 subunit C OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NIP1 PE=3 SV=1
EIF3C_YARLI51.351%7400.0Eukaryotic translation initiation factor 3 subunit C OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NIP1 PE=3 SV=1
UniRef50_Q6C85551.351%7400.0Eukaryotic translation initiation factor 3 subunit C n=6 Tax=Saccharomycetales TaxID=4892 RepID=EIF3C_YARLI
A0A1E4TIG4_9ASCO43.247%7330.0Eukaryotic translation initiation factor 3 subunit C OS=Tortispora caseinolytica NRRL Y-17796 GN=NIP1 PE=3 SV=1
EIF3C_CANAL36.252%7314.22e-144Eukaryotic translation initiation factor 3 subunit C OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=NIP1 PE=3 SV=2
EIF3C_YEAST36.236%7128.29e-140Eukaryotic translation initiation factor 3 subunit C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NIP1 PE=1 SV=2

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1821

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 600 700 800 857

Detailed signature matches

  1. Family IPR027516
    Eukaryotic translation initiation factor 3 subunit C
    1. MF_03002 (eIF3c)
  2. Domain IPR008905
    Eukaryotic translation initiation factor 3 subunit C, N-terminal domain
    1. PF05470 (eIF-3c_N)
  3. Domain IPR000717
    Proteasome component (PCI) domain
    1. SM00088 (PINT_4)
    2. PF01399 (PCI)
  4. Domain IPR011991
    Winged helix-turn-helix DNA-binding domain
    1. G3DSA:1.10.10.10
    2. SSF46785 ("Winged h...)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SM00753 (PINT)
  3. mobidb-lite (disord...)

Protein sequence

>MIA_04113_1
MSRFFQQLSSSESESSEEEKYESSSEEESSEEESSEEESSEEESEDEESDSESDSDSGKGGNNASSFLKSKSKFLKGAES
DSESDSEDESKRVVKSAKDKLLDEIDSIIKSIDNAKKINDWNAISTDFDKLIKSVEKVTKQFGITPKQYVKAVADLEDFA
IETTKTQKASKKKMNASNTKAHSSTTQKVKKNNRTIEKLVSAYRANPEEFLSAPEAAGTAIIQPKNIKITTSFNVPSTQA
EDDDTGFTTVGKPAGDAFATLISIVESRGKKGVDKEKQVTELESLLKSTKDTYLQIIILLRLIPIKFDLAPSGHAVPINV
WNEARDYTTQLLDILESNAAKYELSDSAPEPEELEKGLAPREDGVQEIPGSIVSLVERLDDEFTRSLLEIDPHTTEYVDR
LRDENSLYSLIIRSQIYLENTSKVSFDQYESISRIISRRVDHIYFKPNTAVIAGEKAAWSALDAKLDSKITPRIQEDVSD
EYVIELVGKLCSVLYKQPNTLFRTRAMLCHIYNFALNDMYYKARDLMLMCHLQTNIHGNEIPILILFNRTLIQIGLCAFR
KGLIAECQQTLSDVILSPRLKELLGQGVAKASTTTTTEGKQRMLPFHMHINLEFLECINLTASLLIEIPAIAASENQIDG
KKVVSRNFRRMLDNSSRQVFTGPPENTRDHIMHAARALLDCEWTKARDLLNTIKIWNLLPKPEEIKAMLAEKLQVEGLRT
YLFRYGSTYQSLSFSILSTLFDLPERRVYAIISKMIANEEIDAALDQKTDSVIFRQGVDLSRLQTLALSLSEKAVQLVER
NERLAAGGHQLTETTKTAPNAGPNSNSNSNANNAQSRQSAGGRNDNRRGQQGQNKQR

GO term prediction

Biological Process

GO:0006413 translational initiation

Molecular Function

GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0031369 translation initiation factor binding

Cellular Component

GO:0005852 eukaryotic translation initiation factor 3 complex