Protein

MIA_04104_1

Length
317 amino acids


Browser: contig05:758506-759460+

Protein function

EGGNOG:0PK2GPGUG_05560Uroporphyrinogen-III synthase
SGD closest match:S000005804HEM4Uroporphyrinogen-III synthase
CGD closest match:CAL0000185290HEM4Uroporphyrinogen-III synthase

Protein alignments

%idAln lengthE-value
MCA_00028_149.667%3004.38e-92MCA_00028_1
A0A0J9XGM1_GEOCN40.803%2991.59e-63Similar to Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase OS=Geotrichum candidum GN=BN980_GECA13s02320g PE=4 SV=1
UniRef50_A0A0J9XGM140.803%2993.25e-60Similar to Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGM1_GEOCN
A0A170QXU4_9ASCO40.411%2929.93e-59Uroporphyrinogen-III synthase HEM4 OS=Sugiyamaella lignohabitans GN=HEM4 PE=4 SV=1
A0A1E3PER6_9ASCO32.476%3117.11e-47Tetrapyrrole biosynthesis, uroporphyrinogen III synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52883 PE=4 SV=1
A0A1D8PIS5_CANAL32.333%3003.35e-37Uroporphyrinogen-III synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM4 PE=4 SV=1
HEM4_YEAST42.442%1721.16e-34Uroporphyrinogen-III synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM4 PE=1 SV=2
A0A060SZ43_BLAAD37.278%1691.56e-28ARAD1C05610p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05610g PE=4 SV=1
Q6C2A4_YARLI38.636%1764.38e-28YALI0F09449p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09449g PE=4 SV=1
A0A1E4TGN7_9ASCO29.240%1715.04e-09Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2610 PE=4 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.9803
Predicted cleavage: 30

Protein family membership

None predicted.

Domains and repeats

1 50 100 150 200 250 317

Detailed signature matches

    1. cd06578 (HemD)
    2. PF02602 (HEM4)
    3. SSF69618 (HemD-like)
Unintegrated signatures no IPR
Unintegrated signatures

Residue annotation

  1. active site cd06578

Protein sequence

>MIA_04104_1
MSTTTTTTTKSTLITTATPRRIYLFKNRTVPKDPYHDLFVEHGFEPVFVPLLRHKFINTDELRALVESSEFLNNKNAIII
TSQRAIEAVNEVHATLSREAQQALLSRPVYTVGPASAAALARAGYTDVRGGATAGNGLVLSEIIVRESQERPDEIGEYVF
FTGVTRRDIIPVRLREAKLPLAERVVYQTLAIENLEQHVLSLISAELEEEEASAAEDGAELERDVEEEIEEELLEAEKEG
SLGKSRLDPYYVFFSPAEADPVVEAVRRISQRRAVRVAAIGPTTEEYLAGKALPARVVASKPDAMHLVAAIKADLNE

GO term prediction

Biological Process

GO:0033014 tetrapyrrole biosynthetic process

Molecular Function

GO:0004852 uroporphyrinogen-III synthase activity

Cellular Component

None predicted.