Protein
MCA_00028_1
Length
279 amino acids
Gene name: HEM4
Description: uroporphyrinogen-III synthase
Browser: contigA:74201-75041+
RNA-seq: read pairs 568, FPKM 25.1, percentile rank 47.6% (100% = highest expression)
Protein function
| Annotation: | HEM4 | uroporphyrinogen-III synthase | |
|---|---|---|---|
| KEGG: | K01719 | hemD | uroporphyrinogen-III synthase [EC:4.2.1.75] |
| EGGNOG: | 0PK2G | PGUG_05560 | Uroporphyrinogen-III synthase |
| SGD closest match: | S000005804 | HEM4 | Uroporphyrinogen-III synthase |
| CGD closest match: | CAL0000185290 | HEM4 | Uroporphyrinogen-III synthase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04104_1 | 49.67% | 300 | 4e-91 | MIA_04104_1 |
| A0A0J9XGM1_GEOCN | 44.98% | 269 | 5e-70 | Similar to Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase OS=Geotrichum candidum GN=BN980_GECA13s02320g PE=4 SV=1 |
| UniRef50_A0A0J9XGM1 | 44.98% | 269 | 1e-66 | Similar to Saccharomyces cerevisiae YOR278W HEM4 Uroporphyrinogen III synthase n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XGM1_GEOCN |
| A0A170QXU4_9ASCO | 44.15% | 265 | 1e-68 | Uroporphyrinogen-III synthase HEM4 OS=Sugiyamaella lignohabitans GN=HEM4 PE=4 SV=1 |
| A0A1E3PER6_9ASCO | 40.65% | 278 | 1e-57 | Tetrapyrrole biosynthesis, uroporphyrinogen III synthase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_52883 PE=4 SV=1 |
| HEM4_YEAST | 40.07% | 272 | 2e-57 | Uroporphyrinogen-III synthase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HEM4 PE=1 SV=2 |
| A0A1D8PIS5_CANAL | 38.66% | 269 | 9e-46 | Uroporphyrinogen-III synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=HEM4 PE=4 SV=1 |
| A0A060SZ43_BLAAD | 35.61% | 264 | 5e-42 | ARAD1C05610p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C05610g PE=4 SV=1 |
| Q6C2A4_YARLI | 34.20% | 269 | 1e-40 | YALI0F09449p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_F09449g PE=4 SV=1 |
| A0A1E4TGN7_9ASCO | 29.73% | 259 | 5e-22 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_2610 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0150
Protein family membership
None predicted.
Domains and repeats
-
Domain
1
50
100
150
200
250
279
Detailed signature matches
no IPR
Unintegrated signatures
Residue annotation
-
active site cd06578
Protein sequence
>MCA_00028_1 MTIPDKKRKVYLFKNKTIPQDPYHDLFHSKSFEPIFVPLLRHEFINSDDTASFVESKDFQEGRNALIITSQRAIEALNDQ FPALSKAAQEALLTKPIYTVGPASAEALKRAGYKDIRGGAKAGNGAILSDIIIHDQSSLNDDGQSSFESCVFFTGVTRRD IIPVKLTKAGIALKEIVVYRTYAVENLDSSIQEFYETEKTNSESAVLTPYYVFFSPSEADKAVEAVRKLALTNPIKIAAI GPTTEKYLTEKGIEPNVVARKPDPTHLVEGIFDDCFNKD
GO term prediction
Biological Process
GO:0033014 tetrapyrrole biosynthetic process
Molecular Function
GO:0004852 uroporphyrinogen-III synthase activity
Cellular Component
None predicted.