Protein

MIA_04068_1

Length
551 amino acids

Browser: contig05:656580-658236+

Protein function

EGGNOG:0PF8DPGUG_05535Siroheme synthase
SGD closest match:S000001777MET1Uroporphyrinogen-III C-methyltransferase
CGD closest match:CAL0000185049MET1Uroporphyrinogen-III C-methyltransferase

Protein alignments

%idAln lengthE-value
MCA_00017_160.644%5590.0MCA_00017_1
A0A0J9X3K1_GEOCN60.145%5520.0Similar to Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase OS=Geotrichum candidum GN=BN980_GECA01s10218g PE=3 SV=1
A0A1E3PDJ6_9ASCO58.845%5540.0Uroporphyrin-III C-methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_75975 PE=3 SV=1
A0A060T6B5_BLAAD55.971%5610.0ARAD1B14674p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B14674g PE=4 SV=1
Q6CI67_YARLI50.266%5632.07e-177YALI0A01133p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A01133g PE=3 SV=1
UniRef50_Q6CI6750.266%5634.81e-174YALI0A01133p n=4 Tax=Saccharomycetales TaxID=4892 RepID=Q6CI67_YARLI
A0A1D8PGS2_CANAL49.372%5571.01e-169Uroporphyrinogen-III C-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET1 PE=3 SV=1
A0A167FX84_9ASCO49.281%5564.70e-165Uroporphyrinogen-III C-methyltransferase OS=Sugiyamaella lignohabitans GN=MET1 PE=4 SV=1
A0A1E4TDU0_9ASCO47.187%5513.82e-149Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_98037 PE=3 SV=1
SUMT_YEAST43.271%5878.58e-137Uroporphyrinogen-III C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET1 PE=1 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.1494

Protein family membership

Domains and repeats

  1. Domain
  2. Domain
1 100 200 300 400 500 551

Detailed signature matches

  1. Family IPR012066
    Uroporphyrin-III C-methyltransferase, fungi
    1. PIRSF036555 (SUMT_y...)
  2. Domain IPR006367
    Sirohaem synthase, N-terminal
    1. PF13241 (NAD_binding_7)
  3. Domain IPR028281
    Siroheme synthase, central domain
    1. PF14824 (Sirohm_syn...)
  4. Domain IPR000878
    Tetrapyrrole methylase
    1. SSF53790 (Tetrapyrr...)
    2. PF00590 (TP_methylase)
  5. Domain IPR014777
    Tetrapyrrole methylase, subdomain 1
    1. G3DSA:3.40.10...
  6. Domain IPR006366
    Uroporphyrin-III C-methyltransferase
    1. TIGR01469
  7. Domain IPR014776
    Tetrapyrrole methylase, subdomain 2
    1. G3DSA:3.30.95...
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. G3DSA:1.10.32...
  3. G3DSA:3.30.16...
  4. G3DSA:3.40.50...
  5. SSF75615 (Siroheme ...)
  6. cd11642 (SUMT)
  7. mobidb-lite (disord...)

Residue annotation

  1. active site cd11642
  2. SAM binding site c...
  3. homodimer interfac...

Protein sequence

>MIA_04068_1
MGLLTCQNIQNQVFLVIGTSGLTLTRVQILLEHGARPIVFTSIDLPSQGPASTATKPLSAQTQEKLEELAQAGKISWVQD
RAFTLSDLETRGRDEVSRVVDGVFLTIPKGIKGSLSTLFVSDLYHKCVSTRIPINTADDPEHCTFTLLSTFTKGDFQLGV
STSGKGCRLANRIRREAVSGLPNNIDAICDKVGAVRRRIIAEDDKEEEAERARRTQEEDETGQEDDDADQTNKLNHLVLE
FNESHEQKKKQRLRWLSQIVEYYPLSKLADLSVDELSKEYKQYNEDEKTAAAERASEGKPKGRIALVGAGPGSTGLLTTE
ALQAIKEADIILADKLVPAAVLAQIPRETPVHIAKKFPGNAERAQQELLALGLEGVRAGKYVVRLKQGDPYIFGRGAEEY
LYFEQHGYAPSSVVAGITSALSAPLAARIPPTHRDVADQVLVCTGTGRRGALPRFPEWDDARTVVFLMALHRIGDVVDAL
VAKGWDAGVPCCVIERASCPDQRVIRTRLRDVAEALETAGSRPPGLLVAGRACEVIVKLREDERWRIEEGL

GO term prediction

Biological Process

GO:0000103 sulfate assimilation
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0008152 metabolic process
GO:0019354 siroheme biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0043115 precorrin-2 dehydrogenase activity

Cellular Component

None predicted.