MCA_00017_1
Gene name: MET1
Description: Uroporphyrinogen-III C-methyltransferase
Browser: contigA:44002-45613-
RNA-seq: read pairs 1621, FPKM 37.3, percentile rank 58.8% (100% = highest expression)
Protein function
| Annotation: | MET1 | Uroporphyrinogen-III C-methyltransferase | |
|---|---|---|---|
| KEGG: | K00589 | MET1 | uroporphyrin-III C-methyltransferase [EC:2.1.1.107] |
| EGGNOG: | 0PF8D | PGUG_05535 | Siroheme synthase |
| SGD closest match: | S000001777 | MET1 | Uroporphyrinogen-III C-methyltransferase |
| CGD closest match: | CAL0000185049 | MET1 | Uroporphyrinogen-III C-methyltransferase |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04068_1 | 61.68% | 561 | 0.0 | MIA_04068_1 |
| A0A0J9X3K1_GEOCN | 58.29% | 537 | 0.0 | Similar to Saccharomyces cerevisiae YKR069W MET1 S-adenosyl-L-methionine uroporphyrinogen III transmethylase OS=Geotrichum candidum GN=BN980_GECA01s10218g PE=3 SV=1 |
| A0A1E3PDJ6_9ASCO | 56.57% | 548 | 0.0 | Uroporphyrin-III C-methyltransferase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_75975 PE=3 SV=1 |
| A0A060T6B5_BLAAD | 54.33% | 543 | 0.0 | ARAD1B14674p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1B14674g PE=4 SV=1 |
| Q6CI67_YARLI | 50.56% | 540 | 0.0 | YALI0A01133p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A01133g PE=3 SV=1 |
| UniRef50_Q6CI67 | 50.56% | 540 | 4e-179 | YALI0A01133p n=4 Tax=Saccharomycetales TaxID=4892 RepID=Q6CI67_YARLI |
| A0A1D8PGS2_CANAL | 50.00% | 544 | 0.0 | Uroporphyrinogen-III C-methyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MET1 PE=3 SV=1 |
| A0A167FX84_9ASCO | 50.37% | 538 | 2e-175 | Uroporphyrinogen-III C-methyltransferase OS=Sugiyamaella lignohabitans GN=MET1 PE=4 SV=1 |
| A0A1E4TDU0_9ASCO | 46.90% | 533 | 7e-160 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_98037 PE=3 SV=1 |
| SUMT_YEAST | 44.49% | 535 | 2e-139 | Uroporphyrinogen-III C-methyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MET1 PE=1 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.0672
Predicted cleavage: 29
Protein family membership
- Uroporphyrin-III C-methyltransferase, fungi (IPR012066)
Domains and repeats
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Domain
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Domain
Detailed signature matches
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PIRSF036555 (SUMT_y...)
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PF13241 (NAD_binding_7)
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PF14824 (Sirohm_syn...)
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no IPR
Residue annotation
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SAM binding site c...
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active site cd11642
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homodimer interfac...
Protein sequence
>MCA_00017_1 MSGLLTRHNIANHRYIIFGSSGLTLNRAQTLIEFHAIPIIITPNTKDLSDLAIEKLTELKNQNKLVWYTDREFRLTDLET LGREDVEGVVDGIFLTIPVTPENKKYISEIYQHCLKKRIPINTADCPDMCSFTLLSTFKKGDFQIGVSTSGKGCRLANRI KREAVNALPNNIDEICNRIGELRKRIIEDDEEELVQEVGQDDDDAIQTNKFNDLIIEANESYQQRKKQRLRWLSQVVEYY PLSKLAMLSVEELSKEYSIYKAQNLGQLNSGDVETPIKEASPKPKGKILLVGAGPGSSDLLTTRALRAIKEADIILSDKL VPAPVLDQIPRTTPIHIAKKFPGNAEQAQQEFLDLGLKYASEGKTVVRLKQGDPYIFGRGGEEFLYFKKHGIDIDFNCVV PGITSALSAPLAAGIPPTHREVADQVLICTGTGRRGALPNFPEWEPTRTCVFLMSLHRIDQIVTELTDKKGWDENVPCCV IERANCPDQRIIRSRLKHIVKAIEESGSRPPGLLVTGYACEIIVKLGVDEKWRVEQ
GO term prediction
Biological Process
GO:0000103 sulfate assimilation
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0008152 metabolic process
GO:0019354 siroheme biosynthetic process
GO:0055114 oxidation-reduction process
Molecular Function
GO:0004851 uroporphyrin-III C-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0043115 precorrin-2 dehydrogenase activity
Cellular Component
None predicted.