Protein

MIA_04017_1

Length
349 amino acids

Browser: contig05:516274-517324+

Protein function

EGGNOG:0PH61ADH1alcohol dehydrogenase
SGD closest match:S000004688ADH3Alcohol dehydrogenase 3, mitochondrial
CGD closest match:CAL0000200753ADH2Alcohol dehydrogenase 2

Protein alignments

%idAln lengthE-value
A0A0J9XIH2_GEOCN88.286%3500.0Similar to Saccharomyces cerevisiae YMR083W ADH3 Mitochondrial alcohol dehydrogenase isozyme III OS=Geotrichum candidum GN=BN980_GECA20s01396g PE=3 SV=1
MCA_02220_187.679%3490.0MCA_02220_1
A0A060TBM3_BLAAD78.902%3461.76e-180ARAD1B16786p OS=Blastobotrys adeninivorans GN=AADH1 PE=3 SV=1
A0A167FJP5_9ASCO78.035%3462.65e-179Alcohol dehydrogenase ADH3 OS=Sugiyamaella lignohabitans GN=ADH3 PE=3 SV=1
Q6CGT5_YARLI74.212%3496.71e-172YALI0A16379p OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=YALI0_A16379g PE=3 SV=1
UniRef50_A0A1V2L2I473.851%3481.68e-163Alcohol dehydrogenase 4, mitochondrial n=1 Tax=Cyberlindnera fabianii TaxID=36022 RepID=A0A1V2L2I4_CYBFA
ADH3_YEAST71.387%3467.22e-168Alcohol dehydrogenase 3, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ADH3 PE=1 SV=2
A0A1E3PCI4_9ASCO72.254%3463.30e-165Alcohol dehydrogenase OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_48354 PE=3 SV=1
ADH2_CANAL71.098%3462.81e-165Alcohol dehydrogenase 2 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=ADH2 PE=3 SV=1
A0A1E4TA62_9ASCO68.481%3491.02e-156Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_126711 PE=3 SV=1

Mitochondrial localization by mitoprotII

Probability of mitochondrial location: 0.0305

Protein family membership

None predicted.

Domains and repeats

  1. Domain
  2. Domain
  3. Domain
1 50 100 150 200 250 300 349

Detailed signature matches

  1. Domain IPR011032
    GroES-like
    1. SSF50129 (GroES-like)
  2. Domain IPR020843
    Polyketide synthase, enoylreductase domain
    1. SM00829 (PKS_ER_nam...)
  3. Domain IPR013154
    Alcohol dehydrogenase, N-terminal
    1. PF08240 (ADH_N)
  4. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  5. Domain IPR013149
    Alcohol dehydrogenase, C-terminal
    1. PF00107 (ADH_zinc_N)
  6. SITE IPR002328
    Alcohol dehydrogenase, zinc-type, conserved site
    1. PS00059 (ADH_ZINC)
Unintegrated signatures no IPR
Unintegrated signatures
  1. G3DSA:3.40.50...
  2. G3DSA:3.90.18...
  3. cd08297 (CAD3)

Residue annotation

  1. catalytic Zn bindi...
  2. substrate binding ...
  3. NAD binding site c...
  4. tetramer interface...
  5. structural Zn bind...

Protein sequence

>MIA_04017_1
MSPIPKTQKAVVFESNGGPLLYKDIPVPTPASDEILVNVKYSGVCHTDLHAWKGDWPLPTKLPLVGGHEGAGVVVAKGEN
VTNFEIGDYAGIKWLNGSCLGCEFCLKSAESNCPAAILSGYTHDGSFQQYATAKAVHAAQIPQGTDLAQIAPILCAGITV
YKALKTSEAQPGNWVAITGAGGGLGTLAIQYAKAMGFRVIGIDTGDAKAQACKELGAEAFVDFATSKDLVKDIVEITKGG
PHAVIHVAVSEKALSVSTEYVRPTGVIVLVGLPANAYVKSEVFSHVIKTISIKGSYVGNRADTAEAIDFFTRGLVHCPIK
VVGLSELESVYKLMEKGQIVGRYVLDNSK

GO term prediction

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.