Protein
MIA_04005_1
Length
1,357 amino acids
Browser: contig05:478188-482461-
Protein function
| EGGNOG: | 0PKED | NUT1 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) |
|---|---|---|---|
| SGD closest match: | S000003119 | NUT1 | Mediator of RNA polymerase II transcription subunit 5 |
| CGD closest match: | CAL0000187701 | MED5 | Med5p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MCA_02201_1 | 43.721% | 1091 | 0.0 | MCA_02201_1 |
| A0A0J9XIS4_GEOCN | 36.751% | 868 | 1.42e-167 | Similar to Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA20s01143g PE=4 SV=1 |
| UniRef50_A0A0J9XIS4 | 36.751% | 868 | 2.90e-164 | Similar to Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIS4_GEOCN |
| A0A060T190_BLAAD | 30.330% | 788 | 3.29e-100 | ARAD1C14806p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C14806g PE=4 SV=1 |
| A0A167D9E0_9ASCO | 28.139% | 924 | 5.18e-81 | Nut1p OS=Sugiyamaella lignohabitans GN=NUT1 PE=4 SV=1 |
| A0A1E3PEJ0_9ASCO | 27.283% | 898 | 3.19e-78 | Mediator complex, subunit Med5 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_67175 PE=4 SV=1 |
| MED5_YARLI | 26.791% | 642 | 7.46e-47 | Mediator of RNA polymerase II transcription subunit 5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NUT1 PE=3 SV=2 |
| A0A1E4TBI0_9ASCO | 26.087% | 667 | 5.21e-45 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3743 PE=4 SV=1 |
| MED5_YEAST | 23.684% | 456 | 8.89e-15 | Mediator of RNA polymerase II transcription subunit 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUT1 PE=1 SV=1 |
| A0A1D8PSV9_CANAL | 25.490% | 204 | 1.41e-12 | Med5p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MED5 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.3249
Protein family membership
- Mediator complex, subunit Med5, fungi (IPR014801)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
-
-
mobidb-lite (disord...)
Protein sequence
>MIA_04005_1 MDRQSNIGPINNDSLQNRHINPAQTQPDEKSFSDKQNEQSSLIMIQQNSSIRHPSSSSSSSAAPSFTSGQPQGNQLHRSF SSRKSFTNSKTEQSSVTQLENIISASLQLRLSPQKFLKLYNQIQERIKIDSKSTLEALFHSQSEARTVDTLFLQYISALA FDFKSALSLPNLLYQLRFIQARPQSSNVSTDLLQFYEPLIVVTLSKNLYLWPVQSPNSKTPSNIPSSPPQLRKPQTSNDQ KTADISKGLMIVMIAILEDCSLQGYPLSRQKLRAYSSFLLAFARSGHAAFVIGFNKDVFRKAYDKFECFFIKFTENITSI EPDIGRELQKEYTAVFGKGLNSSSTADSFTKPTRIFRLIWLDTIFRYHRTPSVQLNTELEYFLLTESTTTVVSDLIVTSF DLFAVTIIRKDQPHVIANAKAFLTKRLPLAIKSLILTSQTNLTLDQVELAISQAILSINKETLAIVQSNPNSGDNFDEMF SSSYSVPVGDIRFVLLRSLISLGIVRHSILTKIFNMDVKQANEIPINKVNEDALNNQGLIIDSSNHSFLLTNMAMLANQE KVEYVSFEKSSIKKLVFLLEDLEGIYQERVAFQIFKLMGSWIGSMNTNSIGRLTQALLSHPVLIDILFLHVSMGSFISPL VKLLDDWSQDEDEGNLQDLYTDFGSIILFVLFIFDRYKLDLFDLGINPPELVLPEKTNPKPNNTPNPPISFVTSQIQQSK VSILFDESKSELVSDWISALFGTEGISDELMQRSSAKELYSLVPLIFQQAIEACALKIIDLDTLKGGLEYFLQPFLIPTL VPAIRWICNNIWKQHEIPILLQVIQSLILAECSGDAHRLQQAVLAVTGRELIILLDGINLAASQMASENNPSAALYIIEP KVLSLVQNFYTSSSSELIISQNTSLISSFAAQVKALVQWSSSDSSPPALQTDLLISFIKQIGASKVLFSLLDQLDDFKQS DLLGAAVDVIGSFATMPFLMTNNYYHQKFDENLDQLIVEYTPAKISEIRKTIKEREKEQKLLDQAEQQRAAFIASMSRKG SKSNRSISGPSSRIIANGKANMTQATTDLSKNGQQKLGQGSGLSQGTGDSTKKISLKENISEDLGIGFAKLQKHIQFFHS RRKTMDATITRRYTQAQAQAQAQAQAQLKLKHKFKHKLKPKPKLKHRHKRKHRHKRKLRRKLRRKHKRKHKRKHKRKHRH KRKHKRKLKRKHRHKRKHKLKLKRKLKHKHRHKLKLKLKRKHKRKHKRKHKHKRKLKRKRKHRHKHKHKHKHKHRLKHKH KHRLKHKLKLKLKLKLEHRLKHKHKLGLKHRYKHKHKHKHKHKHKRKHMPKYRCRFQHKFKGRFSLRHSYPQITTFP
GO term prediction
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
Molecular Function
GO:0001104 RNA polymerase II transcription cofactor activity
Cellular Component
GO:0016592 mediator complex