Protein
MCA_02201_1
Length
1,107 amino acids
Gene name: NUT1
Description: Mediator of RNA polymerase II transcription subunit 5
Browser: contigB:575503-579035-
RNA-seq: read pairs 1194, FPKM 13.3, percentile rank 31.4% (100% = highest expression)
Protein function
| Annotation: | NUT1 | Mediator of RNA polymerase II transcription subunit 5 | |
|---|---|---|---|
| KEGG: | K15147 | MED5 | mediator of RNA polymerase II transcription subunit 5 |
| EGGNOG: | 0PKED | NUT1 | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) |
| SGD closest match: | S000003119 | NUT1 | Mediator of RNA polymerase II transcription subunit 5 |
| CGD closest match: | CAL0000187701 | MED5 | Med5p |
Protein alignments
| %id | Aln length | E-value | ||
|---|---|---|---|---|
| MIA_04005_1 | 43.08% | 1091 | 0.0 | MIA_04005_1 |
| A0A0J9XIS4_GEOCN | 36.18% | 984 | 8e-170 | Similar to Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex OS=Geotrichum candidum GN=BN980_GECA20s01143g PE=4 SV=1 |
| UniRef50_A0A0J9XIS4 | 36.18% | 984 | 2e-166 | Similar to Saccharomyces cerevisiae YGL151W NUT1 Component of the RNA polymerase II mediator complex n=1 Tax=Geotrichum candidum TaxID=1173061 RepID=A0A0J9XIS4_GEOCN |
| A0A060T190_BLAAD | 29.29% | 840 | 2e-97 | ARAD1C14806p OS=Blastobotrys adeninivorans GN=GNLVRS02_ARAD1C14806g PE=4 SV=1 |
| A0A167D9E0_9ASCO | 30.92% | 705 | 3e-81 | Nut1p OS=Sugiyamaella lignohabitans GN=NUT1 PE=4 SV=1 |
| A0A1E3PEJ0_9ASCO | 29.09% | 691 | 6e-82 | Mediator complex, subunit Med5 OS=Nadsonia fulvescens var. elongata DSM 6958 GN=NADFUDRAFT_67175 PE=4 SV=1 |
| MED5_YARLI | 27.31% | 648 | 2e-66 | Mediator of RNA polymerase II transcription subunit 5 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=NUT1 PE=3 SV=2 |
| A0A1E4TBI0_9ASCO | 27.42% | 620 | 2e-45 | Uncharacterized protein OS=Tortispora caseinolytica NRRL Y-17796 GN=CANCADRAFT_3743 PE=4 SV=1 |
| MED5_YEAST | 22.88% | 424 | 3e-13 | Mediator of RNA polymerase II transcription subunit 5 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUT1 PE=1 SV=1 |
| A0A1D8PSV9_CANAL | 24.42% | 217 | 4e-11 | Med5p OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=MED5 PE=4 SV=1 |
Mitochondrial localization by mitoprotII
Probability of mitochondrial location: 0.4854
Predicted cleavage: 37
Protein family membership
- Mediator complex, subunit Med5, fungi (IPR014801)
Domains and repeats
None predicted.
Detailed signature matches
no IPR
Unintegrated signatures
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CYTOPLASMIC_D... (C...)
-
-
NON_CYTOPLASM... (N...)
-
TRANSMEMBRANE (Tran...)
-
mobidb-lite (disord...)
Protein sequence
>MCA_02201_1 MDRQSSFGQASSYQQNPHSNTGAPLTRSLSHRQSFTTSTVRANDSTSEVKLERITRASLKLRVPPERYVKLVLQLQSQVK IDESQAFDAIFKTQTNTSFIDSLFLQYVVHLTLEFKSVIPLPKLLFCFRVATENSNAIKTSPEIVSFYEPLIYVALSKSF NTWHQQPLLTPPSTKSSNPNSSGNANSLSQSHKLDSHPLATSGSPKYDIYRMLILILMIFMKGSVMSKEKFPPQKVHAFT SFLYEFAKSGYAAKYLAYSKEVKREEFDGFEDAFIKFVSNLNSFDPSIARSLSQIYSPIFGKGFSLTSTDSMTKPSRVFR LSWLDSLMKMNRLNPIAFMNELEYFLLTESSLTLISELIVASFDAIATSILRKDDSRITNAWKTFILKRLPQCVKNLVYN SPSQITPAQVELVISQAFIAIPKDTFSLIQSYFRAATDNFEEMFAATSASVSNDFRFELLKSLITIHVVPQDALFRILDL NQNSGINVQINPVNIEALQNQGMIIDSSNNSFLLPNIAQAALHENVEYTAFEESNIVKLVFILEDFEGIYQERIAREIVI FVSSWIQTQNTHNLARLVQALLAKPTTIDVLLLNVPIHQLIAPLVSLLDNWNHDEEETNFQDVFTDFGTILLMVLFVYHR YNLDLVDLGIQPPSAINLVLPTKNDPNTEFSVENNKNRARKLSFVASIIRQVGNSEELDDLRDGQSELIGGWISALFDFG GISDDLMKQSSVKDLYFLVPTLFKQAIAARAMNIIEPDTLRGGLDYFLQPFLIPTLVPLIRWICNSLWQEQDIPILLQVI QSLLLTECDGEALRLRQTVLAITGRELFIMLNGINMATGNMAMSNNPDAGLYIVEPRLWSLLEPYYTGGSQVDFLLSNKP SLMASIKQQVNTLVNWQSSESLPPVFYSNLVPLATQQVGATRVLLTLLDAIDAAKNTGHYEATIETVGSLVTMPSVRSNN LYLQMHDSNILAVILDYTPAQILKLRSSREAFKKRQEEIQRMEESKAASLTNSTNPTLRVPKQYNTSVANGKNARTTKMG INSQQQQAIGASKPANSTNEGGSNDLTEGFIKLQQYVQSFHARRRNMETIVAVRAEKLANISNNANK
GO term prediction
Biological Process
GO:0006357 regulation of transcription from RNA polymerase II promoter
Molecular Function
GO:0001104 RNA polymerase II transcription cofactor activity
Cellular Component
GO:0016592 mediator complex